Analysis of mice with single and multiple copies of transgenes reveals a novel arrangement for the λ5-V(preB1) locus control region

Molecular and Cellular Biology

Volumn 19, Issue 1, 1999, Pages 671-679

  Sabbattini, Pierangela ^a   Georgiou, Andrew ^a   Sinclair, Calum ^a   Dillon, Niall ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; GENE CONTROL; GENE LOCUS; GENE REARRANGEMENT; GENE SILENCING; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0032907208     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.19.1.671     Document Type: Article

References (43)

1. Auffray, C., and F. Rougeon. 1980. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumour RNA. Eur. J. Biochem. 107:303-314.
2. Brown, K. E., S. S. Guest, S. T. Smale, K. Hahm, M. Merkenschlager, and A. G. Fisher. 1997. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91:845-854.
3. Caterina, J. J., T. M. Ryan, K. M. Pawlik, R. D. Palmiter, R. L. Brinster, R. R. Behringer, and T. M. Townes. 1991. Human beta-globin locus control region: analysis of the 5′ DNase I hypersensitive site HS 2 in transgenic mice. Proc. Natl. Acad. Sci. USA 88:1626-1630.
4. Dillon, N., and F. Grosveld. 1993. Transcriptional regulation of multigene loci: multilevel control. Trends Genet. 9:134-137.
5. Dillon, N., and F. Grosveld. 1993. Transcriptional analysis using transgenic animals, p. 153-188. In B. D. Hames and S. J. Higgins (ed.), Gene transcription: a practical approach. IRL Press, Oxford, United Kingdom.
6. Eccles, S., N. Sarner, M. Vidal, A. Cox, and F. Grosveld. 1990. Enhancer sequences located 3′ of the mouse immunoglobulin lambda locus specify high-level expression of an immunoglobulin lambda gene in B cells of transgenic mice. New. Biol. 2:801-811.
7. Festenstein, R., M. Tolaini, P. Corbella, C. Mamalaki, J. Parrington, M. Fox, A. Miliou, M. Jones, and D. Kioussis. 1996. Locus control region function and heterochromatin-induced position effect variegation. Science 271:1123-1125.
8. Forrester, W. C., E. Epner, M. C. Driscoll, T. Enver, M. Brice, T. Papayannopoulou, and M. Groudine. 1990. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes Dev. 4:1637-1649.
9. Garrick, D., S. Fiering, D. I. K. Martin, and E. Whitelaw. 1998. Repeats-induced gene silencing in mammals. Nat. Genet. 18:56-59.
10. Greaves, D. R., F. D. Wilson, G. Lang, and D. Kioussis. 1989. Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice. Cell 56:979-986.
11. Grosveld, F., G. B. van Assendelft, D. R. Greaves, and G. Kollias. 1987. Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell 51:975-985.
12. Hagman, J., D. Lo, L. T. Doglio, J. Hackett, Jr., C. M. Rudin, D. Haasch, R. Brinster, and U. Storb. 1989. Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene. J. Exp. Med. 169:1911-1929.
13. Halpren, M. S., and R. Coffman. 1972. Polymer formation and J-chain synthesis in mouse plasmacytomas. J. Immunol. 109:674-682.
14. Henikoff, S. 1998. Conspiracy of silence among repeated transgenes. Bioessays 20:532-535.
15. Ho, S. N., H. D. Hunt, R. M. Horton, J. Pullen, and L. R. Pease. 1989. Site directed mutation by overlap extension using the polymerase chain reaction. Gene 77:51-59.
16. Jeffreys, A. J., A. MacLeod, K. Tamaki, D. L. Neil, and D. G. Monckton. 1991. Minisatellite repeat coding as a digital approach to DNA typing. Nature 354:204-209.
17. Kim, K. J., C. Kanellopoulos-Langevin, R. M. Merwin, D. H. Sachs, and R. Asofsky. 1979. Establishment and characterisation of BALB/c lymphoma lines with B cell properties. J. Immunol. 122:549-554.
18. Kitamura, D., A. Kudo, S. Schaal, W. Muller, F. Melchers, and K. Rajewsky. 1992. A critical role of lambda 5 protein in B cell development. Cell 69:823-831.
19. Kudo, A., and F. Melchers. 1987. A second gene. VpreB in the lambda5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J. 6:2267-2272.
20. Kudo, A., N. Sakaguchi, and F. Melchers. 1987. Organization of the murine Ig-related lambda 5 gene transcribed selectively in pre-B lymphocytes. EMBO J. 6:103-107.
21. Lanier, L. L., and N. L. Warner. 1981. Cell cycle related heterogeneity of Ia antigen expression on a murine lymphoma cell line: analysis by flow cytometry. J. Immunol. 126:626-631.
22. Lo, K., N. R. Landau, and S. T. Smale. 1991. LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes. Mol. Cell. Biol. 11:5229-5243.
23. MacNeil, A., and N. Dillon. Unpublished data.
24. Mai, S., and I. L. Martensson. 1995. The c-myc protein represses the lambda 5 and TdT initiators. Nucleic Acids Res. 23:1-9.
25. Martensson, I., F. Melchers, and T. H. Winkler. 1997. A transgenic marker for mouse B lymphoid precursors. J. Exp. Med. 185:653-661.
26. Martensson, I. L., and F. Melchers. 1994. Pre-B cell-specific lambda 5 gene expression due to suppression in non-pre-B cells. Int. Immunol. 6:863-872.
27. Melchers, F. 1995. The role of B cell and pre-B cell receptors in development and growth control of the B-lymphocyte cell lineage, p. 33-56. In T. Honjo and F. W. Alt (ed.), Immunoglobulin genes. Academic Press, London, United Kingdom.
28. Melchers, F., H. Karasuyama, D. Haasner, S. Bauer, A. Kudo, N. Sakaguchi, B. Jameson, and A. Rolink. 1993. The surrogate light chain in B-cell development. Immunol. Today 14:60-68.
29. Milot, E., J. Strouboulis, T. Trimborn, M. Wijgerde, E. de Boer, A. Lange-veld, K. Tan Un, W. Vergeer, N. Yannoutsos, F. Grosveld, and P. Fraser. 1996. Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell 87:105-114.
30. Minegishi, Y., E. Coustan-Smith, Y. Wang, M. D. Cooper, D. Campana, and M. Conley. 1998. Mutations in the human λ5/14.1 gene result in B cell deficiency and agammaglobulinemia. J. Exp. Med. 187:71-77.
31. Molnár, Á., and K. Georgopoulos. 1994. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol. Cell. Biol. 14: 8292-8303.
32. Murre, C., P. Schonleber-McCaw, H. Vaessin, M. Caudy, L. V. Jan, Y. N. Jan, C. V. Cabrera, J. N. Buskin, S. D. Hauschka, A. B. Lassar, et al. 1989. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58:537-544.
33. Ogawa, M., S. Nishikawa, K. Ikuta, F. Yamamura, M. Naito, K. Takahashi, and S. I. Nishikawa. 1988. B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stroma cell clone, ST-2: B cell progenitor develops first in the embryonal body rather than in the yolk sac. EMBO J. 7:1337-1343.
34. Philipsen, S., D. Talbot, P. Fraser, and F. Grosveld. 1990. The beta-globin dominant control region: hypersensitive site 2. EMBO J. 9:2159-2167.
35. Rolink, A., A. Kudo, H. Karasuyama, Y. Kikuchi, and F. Melchers. 1991. Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. EMBO J. 10:327-336.
36. Schaffer, A. L., and M. S. Schlissel. 1997. A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development. J. Immunol. 159:1265-1275.
37. Sigvardsson, M., M. O'Riordan, and R. Grosschedl. 1997. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light-chain genes. Immunity 7:25-36.
38. Talbot, D., P. Collis, M. Antoniou, M. Vidal, F. Grosveld, and D. R. Greaves. 1989. A dominant control region from the human beta-globin locus conferring integration site-independent gene expression. Nature 338:352-355.
39. Talbot, D., S. Philipsen, P. Fraser, and F. Grosveld. 1990. Detailed analysis of the site 3 region of the human beta globin dominant control region. EMBO J. 9:2169-2177.
40. Tian, J., T. Okabe, T. Miyazaki, S. Takeshita, and A. Kudo. 1997. Pax-5 is identical to EBB-1/KLP and binds to the VpreB and lambda5 promoters. Eur. J. Immunol. 27:750-755.
41. Travis, A., J. Hagman, L. Hwang, and R. Grosschedl. 1993. Purification of early-B-cell factor and characterization of its DNA-binding specificity. Mol. Cell. Biol. 13:3392-3400.
42. Waneck, G. L., and N. Rosenberg. 1981. Abelson leukemia virus induces lymphoid and erythroid colonies in infected fetal cell cultures. Cell 26:79-89.
43. Yang, J., M. A. Glozak, and B. B. Blomberg. 1995. Identification and localization of a developmental stage-specific promoter activity from the murine lambda 5 gene. J. Immunol. 155:2498-2514.