Human HMG box transcription factor HBP1: A role in hCD2 LCR function

EMBO Journal

Volumn 18, Issue 22, 1999, Pages 6396-6406

  Zhuma, Talgat ^a   Tyrrell, Richard ^a   Sekkali, Belaïd ^a   Skavdis, George ^a   Saveliev, Alexander ^a,b   Tolaini, Mauro ^a   Roderick, Kathleen ^a   Norton, Trisha ^a   Smerdon, Steve ^a   Sedgwick, Steve ^a   Festenstein, Richard ^a,b   Kioussis, Dimitris ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Chromatin; HBP1; HMG box; Locus control region; Position effect variegation

Indexed keywords

CD2 ANTIGEN; CURVED DNA; HIGH MOBILITY GROUP PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CENTROMERE; CONTROLLED STUDY; DNA SEQUENCE; GENE CONSTRUCT; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; REGULATOR GENE; TELOMERE; TRANSGENE; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD2; BASE SEQUENCE; BINDING SITES; CLONING, MOLECULAR; DEOXYRIBONUCLEASE I; DNA FINGERPRINTING; ESCHERICHIA COLI; HIGH MOBILITY GROUP PROTEINS; HUMANS; LOCUS CONTROL REGION; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; REPRESSOR PROTEINS; RESTRICTION MAPPING; SEQUENCE DELETION; T-LYMPHOCYTES;

ANIMALIA; MUS MUSCULUS;

EID: 0033570891     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.22.6396     Document Type: Article

References (61)

1. Allshire, R.C, Javerzat, J.P., Redhead, N.J. and Cranston, G. (1994) Position effect variegation at fission yeast centromeres. Cell, 76, 157-169.
2. Aronow, B.J., Ebert, C.A., Valerius, M.T, Potter, S.S., Wiginton, D.A., Witte, D.P. and Hutton, J.J. (1995) Dissecting a locus control region: facilitation of enhancer function by extended enhancer-flanking sequences. Mol. Cell. Biol., 15, 1123-1135.
3. Brehm, A., Miska, E.A., McCance, D.J., Reid, J.L, Bannister, A.J. and Kouzarides, T. (1998) Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature, 391, 597-601.
4. Csink, A.K. and Henikoff, S. (1996) Genetic modification of heterochromatic association and nuclear organization in Drosophila. Nature, 381, 529-531.
5. Dignam, J.D., Lebovitz, R.M. and Roeder, R.G. (1983) Accurate transcription initiation by RNA polymerase II in soluble extract from isolated mammalian nuclei. Nucleic Acids Res., 11, 1475-1489.
6. Dobie, K.W., Lee, M., Fantes, J.A., Graham, E., Clark, A.J., Springbett, A., Lathe, R. and McClenaghan, M. (1996) Variegated transgene expression in mouse mammary gland is determined by the transgene integration locus. Proc. Natl Acad. Sci. USA, 93, 6659-6664.
7. Dobie, K., Mehtali, M, McClenaghan, M. and Lathe, R. (1997) Variegated gene expression in mice. Trends Genet., 13, 127-130.
8. Du, W. and Maniatis, T. (1994) The high mobility group protein HMG I (Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms. Proc. Natl Acad. Sci. USA, 91, 11318-11322.
9. Du, W., Thanos, D. and Maniatis, T. (1993) Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell, 74, 887-898.
10. Dunaief, J.L., Strober, B.E., Guha, S., Khavari, P.A., Alin, K., Luban, J., Begemann, M., Crabtree, G.R. and Goff, S.P. (1994) The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell, 79, 119-130.
11. Farkas, G., Gausz, J., Galloni, M., Reuter, G., Gyurkovics, H. and Karch, F. (1994) The Trithorax-like gene encodes the Drosophila GAGA factor. Nature, 371, 806-808.
12. Festenstein, R., Tolaini, M., Corbella, P., Mamalaki, C., Parrington, J., Fox, M., Miliou, A., Jones, M. and Kioussis, D. (1996) Locus control region and heterochromatin-induced position effect variegation. Science, 271, 1123-1125.
13. Festenstein, R., Sharghi-Namini, S., Fox, M., Roderick, K., Tolaini, M., Norton, T., Savelieu, A., Kioussis, D. and Singh, P. (1999) Heterochromatin protein 1 (M31) modifies mammalian PEV in a dose and chromosomal context dependent manner. Nature Genet., in press.
14. Garrick, D., Sutherland, H., Robertson, G. and Whitlow, E. (1996) Variegated expression of a globin transgene correlates with chromatin accessibility but not methylation status. Nucleic Acids Res., 24, 4902-4909.
15. Garrick, D., Fiering, S., Martin, D.I. and Whitlow, E. (1998) Repeat induced gene silencing in mammals. Nature Genet., 18, 56-59.
16. WAF1/C1P1 transcription by RB binding proteins. Oncogene, 17, 3463-3469.
17. Giese, K., Amsterdam, A. and Grosschedl, R. (1991) DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1. Genes Dev., 5, 2567-2578.
18. Giese, K., Kingsley, C., Kirshner, J.R. and Grosschedl, R. (1995) Assembly and function of a TCRα enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev., 9, 995-1008.
19. Granok, H., Leibovitch, B.A., Shaffer, C.D. and Elgin, S.C. (1995) Chromatin. Ga-ga over GAGA factor. Curr. Biol., 5, 238-241.
20. Grosschedl, R. (1995) Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombination. Curr. Opin. Cell Biol., 7, 362-370.
21. Grosschedl, R., Giese, K. and Pagel, J. (1994) HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet., 10, 94-100.
22. Grosveld, F., van Assendelft, G.B., Greaves, R.D. and Kollias, G. (1987) Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell, 51, 975-985.
23. Grosveld, F., de Boer, E., Dillon, N., Gribnau, J., McMorrow, T., Milot, E., Trimborn, J., Wijgerde, M. and Fraser, P. (1998) The dynamics of globin gene expression and position effects. Novartis Found. Symp., N214, 67-86.
24. Grunstein, M. (1997) Molecular model for telomeric heterochromatin in yeast. Curr. Opin. Cell Biol., 9, 383-387.
25. Guy, L.G., Kothary, R., DeRepentigny, Y., Delvoye, N., Ellis, J. and Wall, L. (1996) The β-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice. EMBO J., 5, 3713-3721.
26. Haynes, T.L., Thomas, M.B., Dusing, M.R., Valerius, M.T., Potter, S.S. and Wiginton, D.A. (1996) An enhancer LEF-I/TCF-1 site is essential for insertion site-independent transgene expression in thymus. Nucleic Acids Res., 24, 5034-5044.
27. Higgs, D.R. (1998) Do LCRs open chromatin domains? Cell, 95, 299-302.
28. Kioussis, D. and Festenstein, R. (1997) Locus control regions: overcoming heterochromatin-induced gene inactivation in mammals. Curr. Opin. Genet. Dev., 7, 614-619.
29. Kioussis, D. and Festenstein, R. (1998) Chromatin structure and lineage determination. In Monroe, J.G. and Rothenberg, E.V. (eds), Molecular Biology of B-Cell and T-Cell Development. Humana Press, Totowa, NJ, pp. 127-146.
30. Kleinjan, D.J. and van Heyningen, V. (1998) Position effect in human genetic disease. Hum. Mol. Genet., 7, 1611-1618.
31. Lake, R., Wotton, D. and Owen, M. (1990) A 3′ transcriptional enhancer regulates tissue-specific expression of the human CD2 gene. EMBO J., 9, 3129-3136.
32. Landsman, D. and Bustin, M. (1993) A signature for the HMG-1 box DNA-binding proteins. BioEssays, 15, 539-546.
33. Lavender, P., Vandel, L., Bannister, A.J. and Kouzarides, T. (1997) The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. Oncogene, 14, 2721-2728.
34. + transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator. Nucleic Acids Res., 22, 3685-3688.
35. Locke, J., Kotarsk, M.A. and Tartof, K.D. (1988) Dosage-dependent modifiers of positional effect variegation in Drosophila and a mass action model that explains their effect. Genetics, 120, 181-198.
36. Love, J.J., Li, X., Case, D.A., Giese, K., Grosschedl, R. and Wright, P.E. (1995) Structural basis for DNA bending by the architectural transcription factor LEF-1. Nature, 376, 791-795.
37. Magnaghi-Jaulin, L., Groisman, R., Naguibneva, I., Robin, P, Lorain, S., Le Villain, J.P., Troalen, F., Trouche, D. and Harel-Bellan, A. (1998) Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature, 391, 601-605.
38. Milot, E. et al. (1996a) Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell, 87, 105-114.
39. Milot, E., Fraser, P. and Grosveld, F. (1996b) Position effects and genetic disease. Trends Genet., 12, 123-126.
40. Oosterwegel, M., van de Wetering, M., Dooijes, D., Klomp, L., Winoto, A., Georgopoulos, K., Meijlink, F. and Clevers, H. (1991) Cloning of murine TCF-1, a T-cell specific transcription factor interacting with functional motifs in the CD3- and T-cell receptor enhancers. J. Exp. Med., 173, 1133-1142.
41. Oosterwegel, M., van de Wetering, M. and Clevers, H. (1993) HMG box proteins in early T-cell differentiation. Thymus, 22, 67-81.
42. Ortiz, B.D., Cado, D., Chen, V., Diaz, P.W. and Winoto, A. (1997) Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues. EMBO J., 16, 5037-5045.
43. Pravtcheva, D.D., Wise, T.L, Ensor, N.J. and Ruddle, F.H. (1994) Mosaic expression of an Hprt transgene integrated in a region of Y heterochromatin. J. Exp. Zool., 268, 452-468.
44. Pruzina, S., Hanscombe, O., Whyatt, D., Grosveld, F. and Philipsen, S. (1991) Hypersensitive site 4 of the human β globin locus control region. Nucleic Acids Res., 19, 1413-1419.
45. Renauld, H., Aparicio, O.M., Zierath, P.D., Billington, B.L., Chhablani, S.K. and Gottschling, D.E. (1993) Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength and by SIR3 dosage. Genes Dev., 7A, 1133-1145.
46. Robertson, G., Garrick, D., Wu, W., Kearns, M., Martin, D. and Whitelaw, E. (1995) Position-dependent variegation of globin transgene expression in mice. Proc. Natl Acad. Sci. USA, 92, 5371-5372.
47. Shih, H.H., Tevosian, S.G. and Yee, A.S. (1998) Regulation of differentiation by HBP1, a target of the retinoblastoma protein. Mol. Cell. Biol., 18, 4732-4473.
48. Strober, B.E., Dunaief, J.L., Guha, S. and Goff, S.P. (1996) Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins. Mol. Cell. Biol., 16, 1576-1583.
49. Talbot, D., Philipsen, S., Fraser, P. and Grosveld, F. (1990) Detailed analysis of the site 3 region of the human β-globin dominant control region. EMBO J., 9, 2169-2177.
50. Tevosian, S., Shih, H., Mendelson, K., Sheppard, K.-A., Paulson, K. and Yee, A. (1997) HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev., 11, 383-396.
51. Thanos, D. and Maniatis, T. (1992) The high mobility group protein HMG I (Y) is required for NF-κB-dependent virus induction of the human IFN-β gene. Cell, 71, 777-789.
52. Thanos, D., Du, W. and Maniatis, T. (1993) The high mobility group protein HMG I (Y) is an essential structural component of a virus-inducible enhancer complex. Cold Spring Harbor Symp. Quant. Biol., 58, 73-81.
53. Travis, A., Amsterdam, A., Belanger, C. and Grosschedl, R. (1991) LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor a enhancer function. Genes Dev., 5, 880-894.
54. Tsukiyama, T., Becker, P.B. and Wu, C. (1994) ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor. Nature, 367, 525-532.
55. Tsukiyama, T. and Wu, C. (1995a) Purification and properties of an ATP-dependent nucleosome remodeling factor. Cell, 83, 1011-1020.
56. Tsukiyama, T, Daniel, C., Tamkun, J. and Wu, C. (1995b) ISWI, a member of the SWI2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factor. Cell, 83, 1021-1026.
57. van de Wetering, M., Oosterwegel, M., Dooijes, D. and Clevers, H. (1991) Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. EMBO J., 10, 123-132.
58. van de Wetering, M., Oosterwegel, M., van Norren, K. and Clevers, H. (1993) Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J., 12, 3847-3854.
59. Wallrath, L.L. (1998) Unfolding the mysteries of heterochromatin. Curr. Opin. Genet. Dev., 8, 147-153.
60. Weiler, K.S. and Wakimoto, B.T. (1995) Heterochromatin and gene expression in Drosophila. Annu. Rev. Genet., 29, 577-605.
61. Yee, A.S., Shih, H.H. and Tevosian, S.G. (1998) New perspectives on retinoblastoma family functions in differentiation. Front. Biosci., 3, D532-D547.