-
1
-
-
0003880161
-
-
New York: Garland Publishing, Inc
-
Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD: Molecular Biology of the Cell. New York: Garland Publishing, Inc; 1994.
-
(1994)
Molecular Biology of the Cell
-
-
Alberts, B.1
Bray, D.2
Lewis, J.3
Raff, M.4
Roberts, K.5
Watson, J.D.6
-
2
-
-
0032142918
-
Roles of histone acetyltransferases and deacetylases in gene regulation
-
Kuo M, Allis CD: Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays 1998, 20:615-626.
-
(1998)
Bioessays
, vol.20
, pp. 615-626
-
-
Kuo, M.1
Allis, C.D.2
-
3
-
-
0030053911
-
Visualizing the spatial relationships between defined DNA sequences and the axial region of extracted metaphase chromosomes
-
Bickmore WA, Oghene K: Visualizing the spatial relationships between defined DNA sequences and the axial region of extracted metaphase chromosomes. Cell 1996, 84:95-104.
-
(1996)
Cell
, vol.84
, pp. 95-104
-
-
Bickmore, W.A.1
Oghene, K.2
-
4
-
-
0032562608
-
Structure and function in the nucleus
-
Lamond AI, Earnshaw WC: Structure and function in the nucleus. Science 1998, 280:547-553.
-
(1998)
Science
, vol.280
, pp. 547-553
-
-
Lamond, A.I.1
Earnshaw, W.C.2
-
5
-
-
0031834613
-
The cellular organization of gene expression
-
Misteli T, Spector DL: The cellular organization of gene expression. Curr Opin Cell Biol 1998, 10:323-331.
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 323-331
-
-
Misteli, T.1
Spector, D.L.2
-
6
-
-
0032560028
-
Cell nucleus: Chromosome dynamics in nuclei of living cells
-
Zink D, Cremer T: Cell nucleus: Chromosome dynamics in nuclei of living cells. Curr Biol 1998, 8:R321-R324.
-
(1998)
Curr Biol
, vol.8
-
-
Zink, D.1
Cremer, T.2
-
7
-
-
0024319521
-
Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro
-
Belmont AS, Braunfeld MB, Sedat JW, Agard DA: Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro. Chromosoma 1989, 98:129-143.
-
(1989)
Chromosoma
, vol.98
, pp. 129-143
-
-
Belmont, A.S.1
Braunfeld, M.B.2
Sedat, J.W.3
Agard, D.A.4
-
8
-
-
0028019457
-
1 chromosomes - A folded, twisted, supercoiled chromonema model of interphase chromatid structure
-
1 chromosomes - A folded, twisted, supercoiled chromonema model of interphase chromatid structure. J Cell Biol 1994, 127:287-302.
-
(1994)
J Cell Biol
, vol.127
, pp. 287-302
-
-
Belmont, A.S.1
Bruce, K.2
-
9
-
-
0000241961
-
Large-scale chromatin organization
-
Edited by Nicolini C. Dordrecht: Kluwer Academic Publishers
-
Belmont AS: Large-scale chromatin organization. In Genome Structure and Function. Edited by Nicolini C. Dordrecht: Kluwer Academic Publishers; 1997:261-276.
-
(1997)
Genome Structure and Function
, pp. 261-276
-
-
Belmont, A.S.1
-
10
-
-
0025170695
-
Interphase and metaphase resolution of different distances within the human dystrophin gene
-
Lawrence JB, Singer RH, McNeil JA: Interphase and metaphase resolution of different distances within the human dystrophin gene. Science, 1990, 249:928-932.
-
(1990)
Science
, vol.249
, pp. 928-932
-
-
Lawrence, J.B.1
Singer, R.H.2
McNeil, J.A.3
-
11
-
-
0027821289
-
Role of chromosome territories in the functional compartmentalization of the cell nucleus
-
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
-
Cremer T, Kurz A, Zirbel R, Dietzel S, Rinke B, Schröck E, Speicher MR, Mathieu U, Jauch A, Emmerich P et al.: Role of chromosome territories in the functional compartmentalization of the cell nucleus. In Cold Spring Harbor Symp Quant Biol. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 1993, 58:777-792.
-
(1993)
Cold Spring Harbor Symp Quant Biol.
, vol.58
, pp. 777-792
-
-
Cremer, T.1
Kurz, A.2
Zirbel, R.3
Dietzel, S.4
Rinke, B.5
Schröck, E.6
Speicher, M.R.7
Mathieu, U.8
Jauch, A.9
Emmerich, P.10
-
12
-
-
0032568321
-
Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells
-
Kanda T, Sullivan KF, Wahl GM: Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr Biol 1998, 8:377-385. A histone H2B-GFP fusion protein was made and characterized. HeLa cells stably expressing the fusion protein showed no change in cell cycle parameters. In vivo imaging using this fusion protein to visualize the intranuclear chromatin distribution revealed fine substructure consistent with the large-scale chromatin organization visualized previously by DAPI (4,6-diamino-2-phenylindole) staining and deconvolution microscopy in aldehyde fixed cells.
-
(1998)
Curr Biol
, vol.8
, pp. 377-385
-
-
Kanda, T.1
Sullivan, K.F.2
Wahl, G.M.3
-
13
-
-
0031954055
-
Structure and dynamics of human interphase chromosome territories in vivo
-
Zink D, Cremer T, Saffrich R, Fischer R, Trendelenburg MF, Ansorge W, Stelzer E: Structure and dynamics of human interphase chromosome territories in vivo. Hum Genet 1998, 102:241-251. Microinjection of fluorescent nucleotides into mammalian cells followed by long chases of several cell cycles and random chromosome segregation produced cells containing a small number of labeled chromosome regions. This system then allowed in vivo visualization of the dynamics of native chromosome domains, confirming the confinement of chromosome regions to compact territories. The shape and position of these regions were stable in general over several hours but there were examples in which small changes in shape and position were visualized.
-
(1998)
Hum Genet
, vol.102
, pp. 241-251
-
-
Zink, D.1
Cremer, T.2
Saffrich, R.3
Fischer, R.4
Trendelenburg, M.F.5
Ansorge, W.6
Stelzer, E.7
-
14
-
-
0030461543
-
In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition
-
Robinett CC, Straight A, Li G, Willhelm C, Sudlow G, Murray A, Belmont AS: In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition. J Cell Biol 1996, 135:1685-1700.
-
(1996)
J Cell Biol
, vol.135
, pp. 1685-1700
-
-
Robinett, C.C.1
Straight, A.2
Li, G.3
Willhelm, C.4
Sudlow, G.5
Murray, A.6
Belmont, A.S.7
-
15
-
-
0032498902
-
Interphase cell cycle dynamics of a late replicating, heterochromatic homogeneously staining region: Precise choreography of condensation/decondensation and intranuclear positioning
-
Li G, Sudlow G, Belmont AS: Interphase cell cycle dynamics of a late replicating, heterochromatic homogeneously staining region: Precise choreography of condensation/decondensation and intranuclear positioning. J Cell Biol 1998, 140:975-989. Previous ultrastructural work has demonstrated a significant heterogeneity in large-scale chromatin structure within a single nucleus. A highly reproducible pattern of condensation and decondensation tightly coupled to cell cycle progression was observed in vivo for a specific amplified chromosome region. Significant large-scale chromatin decondensation appeared to slightly precede initiation of DNA replication and movement of the amplified chromosome region into the nuclear interior.
-
(1998)
J Cell Biol
, vol.140
, pp. 975-989
-
-
Li, G.1
Sudlow, G.2
Belmont, A.S.3
-
17
-
-
0033593366
-
Compartmentalization of interphase chromosomes observed in simulation and experiment
-
Münkel C, Eils R, Dietzel S, Zink D, Mehring C, Wedemann G, Cremer T, Langowski J: Compartmentalization of interphase chromosomes observed in simulation and experiment. J Mol Biol 1999, 285:1053-1065. Human interphase chromosomes were modeled as flexible 30 nm fibers organized into rosettes containing 120 kilobase loops. Simulations of the dynamics of this model were consistent with previous FISH experimental observations of distinct chromosome territories. Simulations were also consistent with published FISH data measuring the distances between pairs of probes, which had previously been interpreted in terms of a giant-loop model.
-
(1999)
J Mol Biol
, vol.285
, pp. 1053-1065
-
-
Münkel, C.1
Eils, R.2
Dietzel, S.3
Zink, D.4
Mehring, C.5
Wedemann, G.6
Cremer, T.7
Langowski, J.8
-
18
-
-
0022386283
-
Radial loops and helical coils coexist in metaphase chromosomes
-
Rattner JB, Lin CC: Radial loops and helical coils coexist in metaphase chromosomes. Cell 1985, 42:291-296.
-
(1985)
Cell
, vol.42
, pp. 291-296
-
-
Rattner, J.B.1
Lin, C.C.2
-
19
-
-
0024212087
-
The metaphase scaffold is helically folded: Sister chromatids have predominately opposite helical handedness
-
Boy de la Tour E, Laemmli UK: The metaphase scaffold is helically folded: Sister chromatids have predominately opposite helical handedness. Cell 1988, 55:937-944.
-
(1988)
Cell
, vol.55
, pp. 937-944
-
-
Boy De La Tour, E.1
Laemmli, U.K.2
-
20
-
-
0025021788
-
A unified model of eukaryotic chromosomes
-
Manuelidis L, Chen TL: A unified model of eukaryotic chromosomes. Cytometry 1990, 11:8-25.
-
(1990)
Cytometry
, vol.11
, pp. 8-25
-
-
Manuelidis, L.1
Chen, T.L.2
-
21
-
-
0025649160
-
A view of interphase chromosomes
-
Manuelidis L: A view of interphase chromosomes. Science 1990, 250:1533-1540.
-
(1990)
Science
, vol.250
, pp. 1533-1540
-
-
Manuelidis, L.1
-
22
-
-
0017583351
-
A direct approach to the structure of eukaryotic chromosomes
-
Sedat J, Manuelidis L: A direct approach to the structure of eukaryotic chromosomes. Cold Spring Harbor Symp Quant Biol 1978, 42:331-350.
-
(1978)
Cold Spring Harbor Symp Quant Biol
, vol.42
, pp. 331-350
-
-
Sedat, J.1
Manuelidis, L.2
-
23
-
-
0030454586
-
Three-dimensional reconstruction of painted human interphase chromosomes: Active and inactive X chromosome territories have similar volumes but differ in shape and surface structure
-
Eils R, Dietzel S, Bertin E, Schröck E, Speicher MR, Ried T, Robert-Nicoud M, Cremer C, Cremer T: Three-dimensional reconstruction of painted human interphase chromosomes: Active and inactive X chromosome territories have similar volumes but differ in shape and surface structure. J Cell Biol 1996, 135:1427-1440.
-
(1996)
J Cell Biol
, vol.135
, pp. 1427-1440
-
-
Eils, R.1
Dietzel, S.2
Bertin, E.3
Schröck, E.4
Speicher, M.R.5
Ried, T.6
Nicoud, M.7
Cremer, C.8
Cremer, T.9
-
24
-
-
0032559293
-
MIX-1: An essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation
-
Lieb JD, Albrecht MR, Chuang P-T, Meyer BJ: MIX-1: An essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation. Cell 1998, 92:265-277. MIX-1, belonging to the SMC protein family, is shown to be a component of the dosage compensation complex that associates with X chromosomes to reduce gene expression in addition to being a component of the mitotic SMC complex associating with mitotic chromosomes. Mutations in this gene disrupt both dosage compensation and mitosis. Assuming that the dosage compensation complex regulates chromosome condensation similarly to the mitotic SMC complex, this work provides perhaps the strongest evidence to date linking large-scale chromatin structure and transcriptional regulation.
-
(1998)
Cell
, vol.92
, pp. 265-277
-
-
Lieb, J.D.1
Albrecht, M.R.2
Chuang, P.-T.3
Meyer, B.J.4
-
25
-
-
0030765204
-
1 interphase nuclei
-
1 interphase nuclei. Chromosome Res 1997, 5:157-166. If large-scale chromatin organization plays a functional role in regulating gene activity, then one would expect chromosome regions rich in housekeeping genes to show a different structure to that of gene poor regions. FISH was used to measure the interphase distances between pairs of probes separated by varying genomic distances within 2 G-band and 3 R-band chromosome regions. Distributions of measured interphase distances indicated a more open chromosome structure for R band regions.
-
(1997)
Chromosome Res
, vol.5
, pp. 157-166
-
-
Yokota, H.1
Singer, M.J.2
Van Den Engh, G.J.3
Trask, B.J.4
-
26
-
-
0030443307
-
Active and inactive genes localize preferentially in the periphery of chromosome territories
-
Kurz A, Lampel S, Nickolenko JE, Bradl J, Benner A, Zirbel RM, Cremer T, Lichter P: Active and inactive genes localize preferentially in the periphery of chromosome territories. J Cell Biol 1996, 135:1195-1205.
-
(1996)
J Cell Biol
, vol.135
, pp. 1195-1205
-
-
Kurz, A.1
Lampel, S.2
Nickolenko, J.E.3
Bradl, J.4
Benner, A.5
Zirbel, R.M.6
Cremer, T.7
Lichter, P.8
-
27
-
-
0015091214
-
Localization of rapidly and slowly labeled nuclear RNA as visualized by high resolution autoradiography
-
Fakan S, Bernhard W: Localization of rapidly and slowly labeled nuclear RNA as visualized by high resolution autoradiography. Exp Cell Res 1971, 67:129-141.
-
(1971)
Exp Cell Res
, vol.67
, pp. 129-141
-
-
Fakan, S.1
Bernhard, W.2
-
28
-
-
0017864664
-
Ultrastructural localization of transcription sites and of RNA distribution during the cell cycle of synchronized CHO cells
-
Fakan S, Nobis P: Ultrastructural localization of transcription sites and of RNA distribution during the cell cycle of synchronized CHO cells. Exp Cell Res 1978, 113:327-337.
-
(1978)
Exp Cell Res
, vol.113
, pp. 327-337
-
-
Fakan, S.1
Nobis, P.2
-
29
-
-
0029826893
-
Ultrastructural localization of active genes in nuclei of A431 cells
-
Wansink DG, Sibon OC, Cremers FF, van Driel R, de Jong L: Ultrastructural localization of active genes in nuclei of A431 cells. J Cell Biochem 1996, 62:10-18.
-
(1996)
J Cell Biochem
, vol.62
, pp. 10-18
-
-
Wansink, D.G.1
Sibon, O.C.2
Cremers, F.F.3
Van Driel, R.4
De Jong, L.5
-
30
-
-
0032487442
-
Transcription sites are not correlated with chromosome territories in wheat nuclei
-
Abranches R, Beven AF, Aragon-Alcaide L, Shaw PJ: Transcription sites are not correlated with chromosome territories in wheat nuclei. J Cell Biol 1998, 143:5-12. The authors used a combination of BrUTP labeling and FISH and found no apparent preferential distribution of transcription sites to the periphery of chromosome territories.
-
(1998)
J Cell Biol
, vol.143
, pp. 5-12
-
-
Abranches, R.1
Beven, A.F.2
Aragon-Alcaide, L.3
Shaw, P.J.4
-
31
-
-
0032487506
-
Large-scale chromosomal movements during interphase progression in drosophila
-
1 to early S phase. Disruption of homologous pairing and heterochromatic associations was seen during S phase. A Rabl configuration is lost roughly 2 hours after mitosis.
-
(1998)
J Cell Biol
, vol.143
, pp. 13-22
-
-
Csink, A.K.1
Henikoff, S.2
-
32
-
-
0029811422
-
Functional architecture of chromosomal DNA domains
-
Razin SV: Functional architecture of chromosomal DNA domains. Crit Rev Euk Gene Expression 1996, 6:247-269.
-
(1996)
Crit Rev Euk Gene Expression
, vol.6
, pp. 247-269
-
-
Razin, S.V.1
-
33
-
-
0033521532
-
Dividing the empire: Boundary chromatin elements delimit the territory of enhancers
-
Udvardy A: Dividing the empire: Boundary chromatin elements delimit the territory of enhancers. EMBO J, 1999, 18:1-8.
-
(1999)
EMBO J
, vol.18
, pp. 1-8
-
-
Udvardy, A.1
-
34
-
-
0032479079
-
Going the distance: A current view of enhancer action
-
Blackwood EM, Kadonaga JT: Going the distance: A current view of enhancer action. Science 1998, 281:61-63.
-
(1998)
Science
, vol.281
, pp. 61-63
-
-
Blackwood, E.M.1
Kadonaga, J.T.2
-
35
-
-
0032582826
-
Do LCRs open chromatin domains?
-
Higgs DR: Do LCRs open chromatin domains? Cell 1998, 95:299-302.
-
(1998)
Cell
, vol.95
, pp. 299-302
-
-
Higgs, D.R.1
-
36
-
-
0032185226
-
The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus
-
Epner E, Reik A, Cimbora D, Telling A, Bender MA, Fiering S, Enver T, Martin DI, Kennedy M, Keller G, Groudine M: The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus. Mol Cell 1998, 2:447-455. Using homologous recombination in ES cells, a 25 kilobase deletion including all sequences homologous to the human LCR was made at the native β-globin locus. In differentiated ES cells and erythroleukemia cells containing this chromosome, a global increased sensitivity to DNasel and developmental transcriptional regulation of the locus was maintained; however, transcription of β-globin was reduced to 5-25% of normal levels. These results suggest that additional sequences, further upstream, are capable of establishing the locus open chromatin state.
-
(1998)
Mol Cell
, vol.2
, pp. 447-455
-
-
Epner, E.1
Reik, A.2
Cimbora, D.3
Telling, A.4
Bender, M.A.5
Fiering, S.6
Enver, T.7
Martin, D.I.8
Kennedy, M.9
Keller, G.10
Groudine, M.11
-
37
-
-
0031708415
-
The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells
-
1 the human β-globin locus LCR was deleted at the native chromosome location using homologous recombination in tissue culture cells and transferred to mouse erythroleukemia cells. Although transcription of all β-globin genes was eliminated, an open chromatin state marked by global increased DNAsel sensitivity remained. Therefore, the LCR as originally defined is not necessary to create the open chromatin state. Also, this work shows the open chromatin state is not sufficient by itself to allow transcription.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 5992-6000
-
-
Reik, A.1
Telling, A.2
Zitnik, G.3
Cimbora, D.4
Epner, E.5
Groudine, M.6
-
38
-
-
0032530174
-
Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
-
Pikaart MJ, Recillas-Targa F, Felsenfeld G: Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes Dev 1998, 12:2852-2862. Dimers of a 1.2 kilobase insulator sequence from the chicken β-globin locus were used to flank a reporter construct. Transgene arrays with insulators produced more consistent expression levels at different chromosome sites and were protected from gradual extinction of transcription during long-term culture. Changes in nuclease accessibility, DNA methylation and histone acetylation accompanied this extinction with uninsulated arrays but changes in nuclease accessibility and histone acetylation were prevented with insulators. Extinction of expression occurred in an all or nothing response over the entire transgene arrays.
-
(1998)
Genes Dev
, vol.12
, pp. 2852-2862
-
-
Pikaart, M.J.1
Recillas-Targa, F.2
Felsenfeld, G.3
-
39
-
-
0029561761
-
SARs are cis DNA elements of chromosome dynamics: Synthesis of a SAR represser protein
-
Strick R, Laemmli UK: SARs are cis DNA elements of chromosome dynamics: Synthesis of a SAR represser protein. Cell 1995, 83:1137-1148.
-
(1995)
Cell
, vol.83
, pp. 1137-1148
-
-
Strick, R.1
Laemmli, U.K.2
-
40
-
-
0032055120
-
In vivo analysis of scaffold-associated regions in drosophila: A synthetic high-affinity SAR binding protein suppresses position effect variegation
-
Girard F, Bello B, Laemmli UK, Gehring WJ: In vivo analysis of scaffold-associated regions in drosophila: A synthetic high-affinity SAR binding protein suppresses position effect variegation. EMBO J 1998, 17:2079-2085. Expression of MATH20, a synthetic protein consisting of 10 repeats of an HMG protein region containing two AT hook domains, was found to suppress position effect variegation of the white gene placed near X chromosome heterochromatin. The predominant component of this heterochromatin is satellite 3, containing SAR activity, making a giant, reiterated SAR. MATH20 expression suppressed topoisomerase 2 binding to this satellite repeat. The authors propose that MATH20 displaces a heterochromatin protein(s), which might be related to SAR function.
-
(1998)
EMBO J
, vol.17
, pp. 2079-2085
-
-
Girard, F.1
Bello, B.2
Laemmli, U.K.3
Gehring, W.J.4
-
41
-
-
0029864437
-
DNA binding specificity of two homeodomain proteins in vitro and in Drosophila embryos
-
Walter J, Biggin MD: DNA binding specificity of two homeodomain proteins in vitro and in Drosophila embryos. Proc Natl Acad Sci USA 1996, 93:2680-2685.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2680-2685
-
-
Walter, J.1
Biggin, M.D.2
-
42
-
-
0031030535
-
Extension of chromatin accessibility by nuclear matrix attachment regions
-
Jenuwein T, Forrester WC, Fernandez-Herrero LA, Laible G, Dull M, Grosschedl R: extension of chromatin accessibility by nuclear matrix attachment regions. Nature 1997, 385:269-272.
-
(1997)
Nature
, vol.385
, pp. 269-272
-
-
Jenuwein, T.1
Forrester, W.C.2
Fernandez-Herrero, L.A.3
Laible, G.4
Dull, M.5
Grosschedl, R.6
-
43
-
-
0030922269
-
The role of insulator elements in defining domains of gene expression
-
Geyer PK: The role of insulator elements in defining domains of gene expression. Curr Opin Genet Dev 1997, 7:242-248.
-
(1997)
Curr Opin Genet Dev
, vol.7
, pp. 242-248
-
-
Geyer, P.K.1
-
44
-
-
0032901198
-
SMC-mediated chromosome mechanics: A conserved scheme from bacteria to vertebrates?
-
Hirano T: Smc-mediated chromosome mechanics: A conserved scheme from bacteria to vertebrates? Genes Dev 1999, 13:11-19.
-
(1999)
Genes Dev
, vol.13
, pp. 11-19
-
-
Hirano, T.1
-
45
-
-
0032171040
-
Chromatin remodeling: A marriage between two families?
-
Pollard KJ, Peterson CL: Chromatin remodeling: A marriage between two families? Bioessays 1998, 20:771-780.
-
(1998)
Bioessays
, vol.20
, pp. 771-780
-
-
Pollard, K.J.1
Peterson, C.L.2
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