Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis

Cancer

Volumn 94, Issue 9, 2002, Pages 2369-2379

  Koul, Anjila ^a   Willén, Roger ^b   Bendahl, Pär Ola ^a   Nilbert, Mef ^a   Borg, Åke ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Complex atypical hyperplasia; DNA ploidy; Endometrial carcinoma; Microsatellite instability

Indexed keywords

BETA CATENIN; DNA; ESTROGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53;

ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CARCINOGENESIS; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; ONCOGENE K RAS; PLOIDY; PRIORITY JOURNAL; PROGNOSIS;

AGED; BETA CATENIN; CYTOSKELETAL PROTEINS; ENDOMETRIAL NEOPLASMS; FEMALE; GENES, P16; GENES, P53; GENES, TUMOR SUPPRESSOR; HUMANS; HYPERPLASIA; JOINT INSTABILITY; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; NEOPLASM INVASIVENESS; PHOSPHORIC MONOESTER HYDROLASES; PLOIDIES; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PTEN PHOSPHOHYDROLASE; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0036569795     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.10498     Document Type: Article

References (66)

1. p53 in endometrial cancer and its putative precursors: Evidence for diverse pathways of tumorigenesis
2. Two pathogenetic types of endometrial carcinoma
3. Histologic correlates and virulence implications of endometrial carcinoma associated with adenomatous hyperplasia
4. Endometrial carcinoma associated with hyperplasia
5. Concomitant endometrial hyperplasia in patients with endometrial carcinoma
6. Endometrial carcinoma associated with hyperplasia-immunohistochemical study of angiogenesis and p53 expression
7. Alterations of the Rb gene and its association with Ki-ras activation and p53 inactivation in endometrial adenocarcinoma
8. Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma
9. Microsatellite instability in sporadic endometrial carcinoma
10. PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma
11. Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias
12. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
13. Genetic instability of microsatellites in endometrial carcinoma
14. Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma
15. Microsatellite instability and somatic mutations in endometrial carcinomas
16. Causes and consequences of microsatellite instability in endometrial carcinoma
17. Clinical significance of microsatellite instability in endometrial carcinoma
18. Favorable survival associated with microsatellite instability in endometrioid endometrial cancers
19. Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors
20. PTEN1 is frequently mutated in primary endometrial carcinomas
21. PTEN/MMAC1 mutations in endometrial cancers
22. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
23. Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: Evidence for inactivation of both alleles
24. PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics
25. Mutational spectra of PTEN/ MMAC1 gene: A tumor suppressor with lipid phosphatase activity
26. PTEN mutations in endometrial carcinomas: A molecular and clinicopathologic analysis of 38 cases
27. Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers
28. Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia
29. Beta-catenin mutation in carcinoma of the uterine endometrium
30. Mutations of the beta-catenin gene in endometrial carcinomas
31. Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: Frequent mutations at codon 34 that cause nuclear accumulation
32. Beta-catenin mutations and aberrant nuclear expression during endometrial tumorigenesis
33. Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway
34. Differences in patterns of TP53 and KRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability
35. K-ras mutations in endometrial carcinomas with microsatellite instability
36. Alterations of the p16 (MTS1) gene in testicular, ovarian, and endometrial malignancies
37. Low frequency of CDKN2 mutation in endometrial carcinomas
38. p16INK4 and p15INK4B alterations in primary gynecologic malignancy
39. Alteration of p16 and p15 genes in common epithelial ovarian tumors
40. Identification of TP53 gene mutations in uterine corpus cancer with short follow-up
41. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
42. Estrogen and progesterone receptor analyses in more than 4,000 human breast cancer samples. A study with special reference to age at diagnosis and stability of analyses
43. Prognostic value of steroid receptor concentration and flow cytometrical DNA measurements in stage I-II endometrial carcinoma
44. Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations
45. Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products
46. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
47. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
48. PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma
49. Nuclear localization of beta-catenin in normal and carcinogenic endometrium
50. K-ras activation in premalignant and malignant epithelial lesions of the human uterus
51. Early mutational activation of the c-Ki-ras oncogene in endometrial carcinoma
52. K-ras point mutations in endometrial carcinoma: Effect on outcome is dependent on age of patient
53. Mutations of the Ki-ras oncogene in carcinoma of the endometrium
54. The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer
55. K-ras gene point mutations in human endometrial carcinomas: Correlation with clinicopathological features and patients' outcome
56. Frequency and prognostic impact of microsatellite instability in a large population-based study of endometrial carcinomas
57. Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium
58. Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer
59. Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene
60. Colorectal cancer with and without microsatellite instability involves different genes
61. Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium
62. Clinico-pathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability
63. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
64. Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma [in process citation]
65. Deletions and insertions in the p53 tumor suppressor gene in human cancers: Confirmation of the DNA polymerase slippage/misalignment model
66. Alteration of p16 and p15 genes in human uterine turnouts