Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers

Molecular Carcinogenesis

Volumn 27, Issue 2, 2000, Pages 110-116

  Yaginuma, Yuji ^a   Yamashita, Tsuyoshi ^a   Ishiya, Takayuki ^a   Morizaki, Atsushi ^a   Katoh, Yasuhito ^a   Takahashi, Tomoaki ^a   Hayashi, Hiroaki ^a   Ishikawa, Mutsuo ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Cancer; Human; Mutation; PTEN MMAC1; Uterine

Indexed keywords

ARTICLE; CARCINOGENESIS; CHROMOSOME 10; CONTROLLED STUDY; ENDOMETRIUM CANCER; EXON; GENE EXPRESSION; GENE MUTATION; GENE STRUCTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CANCER; UTERUS CANCER;

DNA, COMPLEMENTARY; ENDOMETRIAL NEOPLASMS; FEMALE; GENES, NEOPLASM; GENES, TUMOR SUPPRESSOR; HELA CELLS; HUMANS; PHOSPHORIC MONOESTER HYDROLASES; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 0033973189     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(200002)27:2<110::AID-MC6>3.0.CO;2-E     Document Type: Article

References (25)

1. Yaginuma Y, Westphal H. Analysis of the p53 gene in human uterine carcinoma cell lines. Cancer Res 1991;51: 6506-6509.
2. Yaginuma Y, Westphal H. Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Res 1992;52:4195-4199
3. Yaginuma Y, Yamashita K, Kuzumaki N, Fujita M, Shimizu T. Ras oncogene product p21 expression and progression of human ovarian tumors. Gynecol Onco 1992;46:45-50.
4. INK4B in human ovarian carcinoma cell lines. Exp Cell Res 1997;233:233-239.
5. Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancer. Nat Genet 1997;15:356-362
6. Li J, Yen C, Liaw D, Podsypanina K, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275: 1943-1947.
7. Li D-M, Sun H. TEP1, Encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β. Cancer Res 1997;57:2124-2129.
8. Liaw D, Marsh DJ, Li J, et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 1997;16:64-67.
9. Nishida M, Kasahara K, Kaneko M, Iwasaki H. Establishment of a new human endometrial adenocarcinoma cell line, Ishikawa cells, containing estrogen, and progesterone receptors. Acta Obstet Gynaecol Japan 1985;37: 1103-1111.
10. Ausubel FM, Brent R, Kingston RE, et al. Preparation and analysis of RNA. In: Current Protocols in Molecular Biology, Vol. 1, p 4.0.1-4.10.8 New York: Wiley Interscience, 1989.
11. Funk CD, FitzGerald GA. Eicosanoid forming enzyme mRNA in human tissues. Analysis by quantitative polymerase chain reaction. J Biol Chem 1991;266:12508-12513.
12. Yaginuma Y, Nishiwaki K, Kitamura S, Hayashi H, Sengoku K, Ishikawa M. Relaxation of insulin-like growth factor-II gene imprinting in human gynecologic tumors. Oncology 1997;54:502-507.
13. Yaginuma Y, Yamashita T, Takuma N, Katayama H, Ishikawa M. Analysis of the p53 gene in human chorio-carcinoma cell lines. Br J Cancer 1995;71:9-12.
14. Yaginuma Y, Katayama H, Kawai K, Duenas J C, Ishikawa M. Analysis of the retinoblastoma gene in human endometrial carcinoma. Obstet Gynecol 1996;87:755-759.
15. Wang SI, Parsons R, Ittmann M. Homozygous deletion of the PTEN tumor suppressor gene in a subset of prostate adenocarcinomas. Clin Cancer Res 1998;4:811-815.
16. Rasheed BKA, Stenzel TT, McLendon RE, et al. PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res 1997;57:4187-4190.
17. Wang SI, Puc J, Li J, et al. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 1997;57: 4183-4188.
18. Rhei E, Kang L, Bogomolniy F, Federici MG, Borgen PI, Boyd J. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res 1997;57:3657-3659.
19. Kim SK, Su L-K, Oh Y, Kemp BL, Hong WK, Mao L. Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. Oncogene 1998;16:89-93.
20. Guldberg P, Straten P, Birck A, Ahrenkiel V, Kirkin AF, Zeuthen J. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 1997;57:3660-3663.
21. Risinger JI, Hayes AK, Berchuck A, Barrett JC. PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 1997;57: 4736-4738.
22. Tashiro H, Blazes MS, Wu R, et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecologic malignancies. Cancer Res 1997;57: 3935-3940.
23. Kong D, Suzuki A, Zou TT, et al. PTEN1 is frequently mutated in primary endometrial carcinomas. Nat Genet 1997;17:143-144.
24. Maxwell GL, Risinger JI, Tong B, et al. Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers. Gynecol Oncol 1998;70:13-16.
25. Risinger JI, Hayes K, Maxwell GL, et al. PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics. Clin Cancer Res 1998;4: 3005-3010.