Osteoprotegerin and inflammation

European Cytokine Network

Volumn 13, Issue 2, 2002, Pages 144-153

  Kermanac'h, N Saidenberg ^a   Bessis, Natacha ^a   Cohen Solal, M ^a   De Vernejoul, M C ^a   Boissier, Marie Christophe ^a  

^a UNIVERSITÉ PARIS 13   (France)

Author keywords

Bone resorption; Inflammation; Osteoprotegerin; RANK

Indexed keywords

COLONY STIMULATING FACTOR 1; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; CELL RECEPTOR; GLYCOPROTEIN; TNFRSF11B PROTEIN, HUMAN;

ALBERS SCHOENBERG DISEASE; BINDING AFFINITY; BONE EROSION; BONE METABOLISM; CELL ACTIVATION; CELL DIFFERENTIATION; GENE EXPRESSION; HORMONAL REGULATION; IMMUNOMODULATION; INFLAMMATION; LIGAND BINDING; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMAL; GLYCOPROTEINS; HUMAN; INFLAMMATION; OSTEOBLASTS; OSTEOCLASTS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TUMOR NECROSIS FACTOR; ANIMALS; HUMANS; OSTEOPROTEGERIN; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036528435     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (83)

1. RANK
2. RANK is an intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
3. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
4. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
5. RANK
6. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
7. Osteoprotegerin, RANK and RANKL: The good, the bad and the ugly in rheumatoid arthritis
8. Osteoprotegerin
9. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
10. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro
11. Osteoclastogenesis inhibitory factor suppresses osteoclast survival by interfering in the action of stromal cells with the osteoclast
12. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
13. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
14. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin
15. 2D3
16. Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection
17. Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene
18. The role of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
19. Evidence for a role of a tumor necrosis factor-α (TNF-α)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival
20. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
21. OPG, is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
22. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
23. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells
24. TRANCE is a TNF family member that regulates dendritic cell and osteoclast function
25. RANK is essential for osteoclast and lymph node development
26. Activated T cells support osteoclast formation in vitro
27. Cellular mechanisms and the role of cytokines in bone erosions in rheumatoid arthritis
28. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
29. Activated human T cells directly induce osteoclastogenesis from human monocytes: Possible role of T cells in bone destruction in rheumatoid arthritis patients
30. Interleukin-4, interferon-gamma, and prostaglandin E impact the osteoclastic cell-forming potential of murine bone marrow macrophages
31. Anti-tumor necrosis factor alpha therapy of rheumatoid arthritis. Mechanism of action
32. Cytokines in pathogenesis of osteoporosis
33. Pathogenesis of bone erosions in rheumatoid arthritis
34. Role of cytokines in rheumatoid arthritis
35. Modulation of osteoclast differentiation and function by the new member of the tumor necrosis factor receptor and ligand families
36. Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction
37. Interleukin-1β and tumor necrosis factor-α, but not interleukin-6 stimulate osteoprotegerin ligand gene expression in human osteoblastic cells
38. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
39. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
40. Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines
41. Increased B-lymphopoiesis by interleukin-7 induces bone loss in mice with intact ovarian function: Similarity to oestrogen deficiency
42. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor
43. Interleukin-4 inhibits bone resorption through an effect on osteoclasts and proinflammatory cytokines in an ex vivo model of bone resorption in rheumatoid arthritis
44. Murine macrophages secrete interferon-γ upon combined stimulation with interleukin (IL)-12 and IL-18. A novel pathway of autocrine macrophage activation
45. A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma
46. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-gamma production
47. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NF kappa B
48. Synergistic proliferation and activation of natural killers cells by interleukin-12 and interleukin-18
49. Development of CD8+ effector T cells is differentially regulated by IL-18 and IL-12
50. IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells
51. A proinflammatory role for IL-18 in rheumatoid arthritis
52. Interleukin-18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor
53. IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro
54. Gonadal steroids and immunity
55. Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells
56. Estradiol binding to cell surface raises cytosolic free calcium in T cells
57. T lymphocytes subsets in osteoporosis. Effect of 1-alpha hydroxyvitamin D3
58. Quantitative bone histomorphometry and circulating T lymphocyte subsets in postmenopausal osteoporosis
59. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha
60. Dissection of TNF receptor effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death
61. Tumor necrosis factor receptor-associated factors (TRAFs), a family of adapter proteins that regulates life and death
62. Involvement of CRAF1, a relative of TRAF, in CD40 signaling
63. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
64. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling
65. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
66. Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice
67. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappaB and c-Jun N-terminal kinase
68. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and INF-γ
69. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
70. The role of osteoprotegerin and receptor activator of nuclear κB ligand in the pathogenesis and treatment of rheumatoid arthritis
71. Bone resorption by tartrate-resistant acid phosphatase-positive multinuclear cells isolated from rheumatoid synovium
72. A new mechanism of bone destruction in rheumatoid arthritis; synovial fibroblasts induce osteoclastogenesis
73. Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis
74. Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis
75. Expression of osteoclast differentiation factor at sites of bone erosion in collagen-induced arthritis
76. Changes in location and number of tartrate resistant acid phosphatase (TRAP)-positive cells during the development of type II collagen-induced arthritis in DBA/1J mice
77. The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption
78. Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint
79. Rheumatoid arthritis synovial macrophage-osteoclast differentiation is osteoprotegerin ligand-dependent
80. Presence of osteoclastogenesis inhibitory factor/osteoprotegerin in synovial fluids from patients with rheumatoid arthritis
81. Osteoprotegerin (OPG) has potent and sustained anti-resorptive activity in post menopausal women
82. IL-4 gene therapy for collagen arthrithis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion
83. Arthritis patterns in rats with adjuvant-induced arthritis define distinct mechanisms of joint protection for IL-1Ra, sTNF-RI, and OPG