Heart 6-phosphofructo-2-kinase activation by insulin results from Ser- 466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B

Journal of Biological Chemistry

Volumn 274, Issue 43, 1999, Pages 30927-30933

  Bertrand, Luc ^a   Alessi, Dario R ^b   Deprez, Johan ^a   Deak, Maria ^b   Viaene, Eric ^a   Rider, Mark H ^a   Hue, Louis ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 6 PHOSPHOFRUCTO 2 KINASE; CASEIN KINASE; CITRIC ACID; FRUCTOSE 6 PHOSPHATE; GLUTAMIC ACID; HEART ENZYME; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; SERINE; WORTMANNIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CATTLE; CELL LINE; ENZYME ACTIVATION; HUMANS; INSULIN; KINETICS; MUTAGENESIS, SITE-DIRECTED; MYOCARDIUM; PEPTIDE FRAGMENTS; PHOSPHOFRUCTOKINASE-2; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS; SERINE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION;

EID: 0032741437     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.43.30927     Document Type: Article

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