메뉴 건너뛰기




Volumn 20, Issue 3, 2002, Pages 110-115

Functional cell-based uHTS in chemical genomic drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; DRUG THERAPY; GENES; SCREENING;

EID: 0036498752     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-7799(02)01906-6     Document Type: Review
Times cited : (59)

References (38)
  • 1
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: A historical perspective
    • (2000) Science , vol.287 , pp. 1960-1964
    • Drews, J.1
  • 2
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • (2001) Nature , vol.409 , pp. 860-921
  • 11
    • 0033039911 scopus 로고    scopus 로고
    • Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product
    • (1999) Mol. Pharmacol. , vol.56 , pp. 235-242
    • Christopoulos, G.1
  • 12
    • 0031434924 scopus 로고    scopus 로고
    • Differences between natural and recombinant G protein-coupled receptor systems with varying receptor/G protein stoichiometry
    • (1997) Trends Pharmacol. Sci. , vol.18 , pp. 456-464
    • Kenakin, T.1
  • 13
    • 0033028258 scopus 로고    scopus 로고
    • CPCCOEt, a non-competitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding
    • (1999) Mol. Pharmacol. , vol.55 , pp. 453-461
    • Litschig, S.1
  • 17
    • 0032489093 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1
  • 18
    • 0033575930 scopus 로고    scopus 로고
    • Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
    • (1999) Nature , vol.401 , pp. 282-286
    • Ames, R.S.1
  • 22
    • 0028986883 scopus 로고
    • High throughput assays of cloned adrenergic, muscarinic, neurokinin, and neurotrophin receptors in living mammalian cells
    • (1995) Pharmacol. Toxicol. , vol.76 , pp. 308-311
    • Messier, T.L.1
  • 23
    • 0028198301 scopus 로고
    • Tools for investigating functional interactions between ligands and G-protein-coupled receptors
    • (1994) Trends Neurosci. , vol.17 , pp. 142-146
    • Lerner, M.R.1
  • 24
    • 0032722628 scopus 로고    scopus 로고
    • Amphibian melanophore technology as a functional screen for antagonists of G-protein coupled 7-transmembrane receptors
    • (1999) J. Biomol. Screening , vol.4 , pp. 269-278
    • Nuttall, M.E.1
  • 27
    • 0032858740 scopus 로고    scopus 로고
    • Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 13-20
    • Porter, R.H.1
  • 28
    • 0031260472 scopus 로고    scopus 로고
    • A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor
    • (1997) Anal. Biochem. , vol.252 , pp. 115-126
    • Stables, J.1
  • 29
    • 0032472195 scopus 로고    scopus 로고
    • Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter
    • (1998) Science , vol.279 , pp. 84-88
    • Zlokarnik, G.1
  • 30
    • 0032949754 scopus 로고    scopus 로고
    • High throughput quantitation of cAMP production mediated by activation of seven transmembrane domain receptors
    • (1999) J. Biomol. Screening , vol.4 , pp. 27-32
    • Kariv, I.I.1
  • 32
    • 0033812568 scopus 로고    scopus 로고
    • A novel high throughput chemiluminescent assay for the measurement of cellular cyclic adenosine monophosphate levels
    • (2000) J. Biomol. Screening , vol.5 , pp. 239-248
    • Chiulli, A.C.1
  • 33
    • 0030610646 scopus 로고    scopus 로고
    • 2+ based on green fluorescent proteins and calmodulin
    • (1997) Nature , vol.388 , pp. 882-887
    • Miyawaki, A.1
  • 34
    • 0033622319 scopus 로고    scopus 로고
    • A genetically encoded, fluorescent indicator for cyclic AMP in living cells
    • (2000) Nat. Cell Biol. , vol.2 , pp. 25-29
    • Zaccolo, M.1
  • 36
    • 0033510286 scopus 로고    scopus 로고
    • A comparative cell-based high throughput screening strategy for the discovery of selective tyrosine kinase inhibitors with anticancer activity
    • (1999) Anticancer Drug Des. , vol.14 , pp. 393-402
    • Stratowa, C.1
  • 37
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • (1997) Adv. Drug Deliv. Rev. , vol.23 , pp. 3-25
    • Lipinski, C.A.1
  • 38
    • 0031595885 scopus 로고    scopus 로고
    • Paclitaxel (Taxol): A success story with valuable lessons for natural product drug discovery and development
    • (1998) Med. Res. Rev. , vol.18 , pp. 315-331
    • Cragg, G.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.