In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: A potential role for 4-hydroxynonenal

Alcoholism: Clinical and Experimental Research

Volumn 25, Issue 6, 2001, Pages 862-871

  Ramachandran, Vinitha ^a   Perez, Antonio ^a   Chen, Juanjuan ^a   Senthil, Duraisamy ^a   Schenker, Steven ^a   Henderson, George I ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

4 Hydroxynonenal; Apoptosis; Brain; Ethanol; Mitochondria

Indexed keywords

4 HYDROXYNONENAL; ALCOHOL; APOPTOSIS INDUCING FACTOR; CASPASE 3; CELL DNA; CYTOCHROME C;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; DNA DEGRADATION; FETAL ALCOHOL SYNDROME; FETUS; LIPID OXIDATION; NERVE CELL NECROSIS; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0034972410     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2001.tb02292.x     Document Type: Article

References (67)

1. Prenatal ethanol exposure permanently reduces the number of pyramidal neurons in rat hippocampus
2. Ethanol promotes apoptosis in cerebellar granule cells by inhibiting the trophic effect of NMDA
3. 2 family mRNA levels in the rat cerebellar vermis
4. Alcohol-induced neuronal loss in developing rats: Increased brain damage with binge drinking
5. Dual responses of CNS mitochondria to elevated calcium
6. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss
7. Ethanol-induced neural crest apoptosis is coincident with their endogenous death, but is mechanistically distinct
8. Ethanol induces Fas/Apo [apoptosis]-1mRNA and cell suicide in the developing cell cortex
9. Inhibition of mitochondrial adenine nucleotide translocator by lipid peroxidation products
10. 4-Hydroxynonenal (HNE) levels are enhanced in fetal liver mitochondria by in utero ethanol exposure
11. Caspases: The executioners of apoptosis
12. Natural loss of Purkinje cells during development and increased loss with alcohol
13. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis
14. Effect of ethanol on rat fetal hepatocytes: Studies on cell replication, lipid peroxidation and glutathione
15. Impaired brain growth in neonatal rat pups exposed to ethanol
16. Aldehydic products of lipid peroxidation
17. Aldehydes formed by lipid peroxidation: Mechanisms of formation, occurrence, and determination
18. Long-term deficits in cerebellar growth and rotarod performance of rats following "binge-like" alcohol exposure during the neonatal brain growth spurt
19. Oligodendrocyte apoptosis mediated by caspase activation
20. Catalase mediates acetaldehyde formation from ethanol in fetal and neonatal rat brain
21. In utero ethanol exposure elicits oxidative stress in the rat fetus
22. The effects of chronic and acute alcohol administration on fetal development in the rat
23. Glutathione oxidation and embryotoxicity elicited by diamide in the developing rat conceptus in vitro
24. Bcl2 functions in an antioxidant pathway to prevent apoptosis
25. Is ethanol-induced cell death in the neonatal rat cerebellum an early caspase-3-dependent apoptotic event?
26. Comparative study of survival signal withdrawal and 4-hydroxynonenal-induced cell death in cerebellar granule cells
27. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
28. Malformations induced in cultured rat embryos by enzymically generated active oxygen species
29. Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage
30. Mitochondrial control of cell death
31. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis
32. Pivotal role of mitochondrial calcium uptake in neural apoptosis and necrosis
33. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
34. 4-Hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death
35. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
36. The mitochondrion in cell death control: Certainties and incognita
37. Developing rat Purkinje cells are more vulnerable to alcohol-induced depletion during differentiation than during neurogenesis
38. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid-peptide
39. Inhibition of glutathione synthesis in the newborn rat: A model for endogenously produced oxidative stress
40. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
41. Glial-derived neurotrophic factor (GDNF) prevents ethanol- induced apoptosis and JUN kinase phosphorylation
42. Generation of neurons in the rat dentate gyrus and hippocampus: Effects of prenatal and postnatal treatment with ethanol
43. Limited ethanol exposure selectively alters the proliferation of precursor cells in the cerebral cortex
44. Effects of prenatal exposure to ethanol on the number of axons in the pyramidal tract of the rat
45. Intracellular recording and injection study of corticospinal neurons in the rat somatosensory cortex: Effect of prenatal exposure to alcohol
46. Number of neurons and glia in mature rat somatosensory cortex: Effect of prenatal exposure to alcohol
47. Ethanol-induced oxygen radical formation and lipid peroxidation in rat brain: Effect of chronic alcohol consumption
48. Apoptosis and DNA fragmentation as induced by tertiary butylhydroperoxide in the brain
49. 2 and Bax mRNA expressions in the mouse brain
50. Permanent neuronal cell loss in the inferior olive of adult rats exposed to alcohol during the brain growth spurt: A stereological investigation
51. Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore
52. Preparation and characterization of mitochondria and submitochondrial particles of rat liver and liver-derived tissues
53. Intragastric intubation of alcohol during postnatal development of rats results in selective cell loss in the cerebellum
54. Protein translocation in apoptosis
55. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
56. Effect of in utero effect of alcohol on glutathione levels in brain and liver
57. Control of apoptosis by the cellular ATP level
58. Gene induction of gamma-irradiation leads to DNA fragmentation in thymocytes
59. +-ATPase
60. Different pathways of in vitro ethanol-induced apoptosis in thymocytes and splenic T and B lymphocytes
61. Trace analysis of aldehydes by precolumn fluorogenic labeling with 1,3-cyclohexanedione and reversed-phase high-performance liquid chromatography
62. Molecular characterization of mitochondrial apoptosis-inducing factor (AIF)
63. Fetal alcohol syndrome: The vulnerability of the developing brain and possible mechanisms of damage
64. Cell population depletion associated with fetal alcohol brain damage: Mechanisms of BAC-dependent cell loss
65. Delay in brain development induced by alcohol in artificially reared rat pups
66. 2 inhibits death of central neural cells induced by multiple agents
67. Apaf-1, a human protein homologous to C. elegans Ced-4, participates in cytochrome c-dependent activation of caspase-3