Experimental infection of Balb/c mice with Leishmania panamensis and Leishmania mexicana: Induction of early IFN-γ but not IL-4 is associated with the development of cutaneous lesions

Scandinavian Journal of Immunology

Volumn 46, Issue 1, 1997, Pages 35-40

  Guevara Mendoza, O ^a,b   Une, C ^a   Franceschi Carreira, P ^b   Orn A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSIDAD DE PANAMÁ   (Panama)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; EXPERIMENTAL MODEL; GENE EXPRESSION; LEISHMANIA; LEISHMANIA MEXICANA; MOUSE; NONHUMAN; PARASITE VIRULENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SKIN LEISHMANIASIS;

EID: 0030754082     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-96.x     Document Type: Article

References (35)

1. Blackwell J. Protozoal infections. In: Wakelin D, Blackwell J, eds. Genetics of Resistance to Bacterial and Parasitic Infection. London: Taylor and Francis, 1988:103.
2. Satoskar A, Bluethmann H, Alexander J. Disruption of murine interlukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection. Infect Immun 1995;63:4894-9.
3. Rojas J, Tani E, Örn A, Sanchez C, Goto H. Leishmania (Viannia) panamensis-induced cutaneous leishmaniasis in Balb/c mice: pathology. Int J Exp Path 1993;74:481-91.
4. Goto H, Rojas J, Sporrong L, Sanchez C, De Carreira P, Örn A. Leishmania (Viannia) panamensis in susceptible and resistant mice: cell mediated and humoral immune responses. Rev Inst Med Trop de Sao Paulo 1995;37:475-81.
5. + effector cells default to the Th2 pathway in interferon γ-deficient mice infected with Leishmania major. J Exp Med 1994;179:1367-71.
6. Scharton-Kersten T, Scott P. The role of the innate immune response in Th1 cell development following Leishmania major infection. J Leukoc Biol 1995;57:515-22.
7. Leal L, Moss D, Kuhn R, Muller W, Liew F. Interleukin-4 transgenic mice of resistant background are susceptible to Leishmania major infection. Eur J Immunol 1993;23:566-9.
8. Locksley R, Scott P. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol Today 1991;12:A58-A61.
9. Heinzel F, Schoenhaut D, Rerko R, Rosser L, Gately M. Recombinant interlukin 12 cures mice infected with Leishmania major. J Exp Med 1993;177:1505-9.
10. Chatelain R, Varkila K, Coffman R. IL-4 induces a Th2 response in Leishmania major-infected mice. J Immunol 1992;148:1182-7.
11. Sypek J, Chung C, Mayor S et al. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med 1993;177:1797-802.
12. Morris L, Troutt A, McLeod K, Kelso A, Handman E, Aebischer T. Interlukin-4 but not gamma interferon production correlates with the severity of murine cutaneous leishmaniasis. Infect Immun 1993;61:3459-65.
13. Reiner S, Zheng S, Wang Z-E, Stowring L, Locksley R. Leishmania promastigotes evade interlukin-12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. J Exp Med 1994;179:447-56.
14. Grimaldi G, David J, McMahon-Pratt D. Identification and distribution of new world Leishmania species characterized by serodeme analysis using monoclonal antibodies. Am J Trop Hyg 1987;36:270-87.
15. Lopez M, Inga R, Cangalaya M et al. Diagnosis of Leishmania using the polymerase chain reaction: a simplified procedure for field work. Am J Trop Med Hyg 1993;49:348-56.
16. Pacheco R, Lopes U, Morel C, Grimaldi G, Momen H. Schizodeme analysis of Leishmania isolates and comparison with some phenotypic techniques. In: Coll. Int. CNRS/INSERM/IMEEE. Montpellier, 1986:57-65.
17. Weigle K, de Davalos M, Heredia P, Molineros R, Saravia N, D'Alessandro A. Diagnosis of cutaneous and mucocutaneous leishmaniasis in Colombia: a comparision of seven methods. Am J Trop Med Hyg 1987;36:489-96.
18. Lagoo-Deenadayalan S, Lagoo A, Barber W, Hardy K. A standardized approach to PCR-based semiquantitation of multiple cytokine gene transcripts from small cell samples. Lymphok Cytok Res 1993;12:59-67.
19. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
20. Gilliland G, Perrin S, Blanchard K, Bunn H. Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction. Proc Natl Acad Sci USA 1990;87:2725-6.
21. O'Garra A, Vieira P. Polymerase chain reaction for detection of cytokine gene expression. Curr Opin Immunol 1992;4:211-15.
22. Siebert P, Larrick J. Competitive PCR. Nature 1992;359:557-9.
23. Rottenberg M, Sporrong L, Persson I, Wigzell H, Örn A. Cytokine gene expression during infection of mice lacking CD4 and/or CD8 with Trypanosoma cruzi. Scand J Immunol 1995;41:164-70.
24. Laskay T, Diefenbach A, Röllinghoff M, Solbach W. Early parasite contaiment is decisive for resistance to Leishmania major infection. Eur J Immunol 1995;25:2220-7.
25. Alfonso L, Scott P. Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis. Infect Immun 1993;61:2952-9.
26. Laskay T, Röllinghoff M, Solbach W. Natural killer cells participate in the early defense against Leishmania major infection in mice. Eur J Immunol 1993;23:2237-41.
27. Scharton T, Scott P. Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J Exp Med 1993;178:567-77.
28. Stenger S, Thüring H, Röllinghoff M, Bogdan C. Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major. J Exp Med 1994;180:783-93.
29. Scharton-Kersten T, Afonso L, Wysocka M, Trinchieri G, Scott P. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol 1995;154:5320-30.
30. Wenner C, Güler M, Macatonia S, O'Garra A, Murphy K. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. J Immunol 1996;156:1442-7.
31. -. Eur J Immunol 1995;25:3298-307.
32. Güler M, Gorham J, Hsieh C-S et al. Genetic susceptibility to Leishmania IL-12 responsiveness in Th1 cell development. Science 1996;271:984-7.
33. Noben-Trauth N, Kropf P, Müler I. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 1996;271: 987-90.
34. Kopf M, Brombacher F, Köhler G et al. IL-4-deficient Balb/c mice resist infection with Leishmania major. J Exp Med 1996;184:1127-36.
35. Lezama-Davila C, Williams D, Gallager G, Alexander J. Cytokine control of Leishmania infection in the Balb/c mouse: enhancement and inhibition of parasite growth by local administration of IL-2 or IL-4 is species and time dependent. Parasite Immunol 1992;14:37-48.