Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis

Journal of Experimental Medicine

Volumn 191, Issue 6, 2000, Pages 1063-1067

  Kima, Peter E ^a   Constant, Stephanie L ^a   Hannum, Lynn ^a   Colmenares, Maria ^a   Lee, Karen S ^a   Haberman, Ann M ^a   Shlomchik, Mark J ^a   McMahon Pratt, Diane ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen presentation; Fc receptor; Infection; Leishmania; Pathogenesis

Indexed keywords

ANTIBODY; FC RECEPTOR;

AMASTIGOTE; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; INTERNALIZATION; KNOCKOUT MOUSE; LEISHMANIA MEXICANA; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SKIN LEISHMANIASIS;

ANIMALS; ANTIBODIES, PROTOZOAN; IMMUNIZATION, PASSIVE; LEISHMANIA MEXICANA; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, FC; RECEPTORS, IGG;

EID: 0034689062     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.6.1063     Document Type: Article

References (28)

1. Evidence that Leishmania donovani utilizes a mannose receptor on human mononuclear phagocytes to establish intracellular parasitism
2. Roles of CR3 and mannose receptors in the attachment and ingestion of Leishmania donovani by human mononuclear phagocytes
3. The major surface protein of Leishmania promastigotes is a fibronectin-like molecule
4. Antibodies raised against synthetic peptides from the Arg-Gly-Asp-containing region of the Leishmania surface protein gp63 cross-react with human C3 and interfere with gp-63-mediated binding to macrophages
5. CR1, the C3b receptor, mediates binding of infective Leishmania major promastigotes to human macrophages
6. Activation of the alternative complement pathway by Leishmania promastigotes: Parasite lysis and attachment to macrophages
7. Leishmania promastigotes require serum opsonic complement to bind to the human leukocyte integrin Mac-1 (CD11b/ CD18)
8. Immune adherence-mediated opsonophagocytosis: The mechanism of Leishmania infection
9. The role of macrophage receptors in adhesion and uptake of Leishmania mexicana amastigotes
10. Leishmania amazonensis: The phagocytosis of amastigotes by macrophages
11. Comparison of receptors required for entry of Leishmania major amastigotes into macrophages
12. Leishmania-infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4+ T cells
13. Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection
14. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the J(H) locus
15. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
16. FcR chain deletion results in pleiotropic effector cell defects
17. Leishmania pifanoi amastigote antigens protect mice against cutaneous leishmaniasis
18. The role of FcR in immunity: Lessons from gene targeting in mice
19. The role of the innate immune response in Th1 cell development following Leishmania major infection
20. + T Cells is sufficient to mediate T helper cell type 1 development
21. Antimicrobial response of a T cell-deficient host to cytokine therapy: Effect of interferon-gamma in experimental visceral leishmaniasis in nude mice
22. Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: Selective impairment of IL-12 induction in Leishmania-infected cells
23. A study of the differential respiratory burst activity elicited by promastigotes and amastigotes of Leishmania donovani in murine resident peritoneal macrophages
24. Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants
25. Role of B cells and Fc receptors ira the selection of T cell epitopes
26. Colocalization of f-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages
27. Molecular definition of distinct cytoskeletal structures involved in complement- and Fc-receptor mediated phagocytosis in macrophages
28. Presentation of the protective parasite antigen LACK by Leishmania-infected macrophages