An industrial perspective on utilizing functional ion channel assays for high throughput screening

Receptors and Channels

Volumn 8, Issue 5-6, 2002, Pages 269-282

  Worrley III, Jennings F ^a   Main, Martin J ^b  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

High throughput screening; Ion channels; Ion flux; Membrane potential

Indexed keywords

BARBITURIC ACID DERIVATIVE; CALCIUM ION; CARBOCYANINE; CELL PROTEIN; FLUORESCENT DYE; GREEN FLUORESCENT PROTEIN; ION; ION CHANNEL; IONOPHORE; LECTIN; MEROCYANINE; PEPTIDE; POTASSIUM ION; RHODAMINE; SCORPION VENOM; SODIUM ION; TETRAMETHYLAMMONIUM; TETRODOTOXIN; VALINOMYCIN; VERATRIDINE; CELL SURFACE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND;

ANALYTICAL EQUIPMENT; CELL ASSAY; CELL MEMBRANE POTENTIAL; CELL SELECTION; DRUG DETERMINATION; FLUORESCENCE ANALYSIS; FLUOROMETRY; GENETIC ANALYSIS; ION TRANSPORT; ISOTOPE LABELING; POTENTIOMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS; ANIMAL; AUTOMATION; BINDING SITE; BIOCHEMISTRY; BIOTECHNOLOGY; CHEMISTRY; DRUG DESIGN; HUMAN; METHODOLOGY; PROTEIN BINDING;

SCORPIONES;

ALLOSTERIC SITE; ANIMALS; AUTOMATION; BINDING SITES; BIOCHEMISTRY; BIOTECHNOLOGY; DRUG DESIGN; GTP-BINDING PROTEINS; HUMANS; ION CHANNELS; IONS; LIGANDS; MEMBRANE POTENTIALS; PROTEIN BINDING; RECEPTORS, CELL SURFACE;

EID: 0036452735     PISSN: 10606823     EISSN: None     Source Type: Journal    
DOI: 10.1080/10606820214643     Document Type: Review

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