LPS in microbial pathogenesis: Promise and fulfilment

Journal of Endotoxin Research

Volumn 8, Issue 5, 2002, Pages 329-335

  Beutler, Bruce ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; TOLL LIKE RECEPTOR 4;

GENE TARGETING; GENETIC ANALYSIS; HUMAN; IMMUNE SYSTEM; MOLECULAR CLONING; NONHUMAN; PARALOGY; PATHOGENESIS; REVIEW; SALMONELLA TYPHIMURIUM; TRANSDUCER;

ANIMALS; BACTERIA; FORECASTING; IMMUNITY, NATURAL; LIPID A; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

BACTERIA (MICROORGANISMS); SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0036449471     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805102125000650     Document Type: Review

References (53)

1. Rietschel ET, Westphal O. Endotoxin: historical perspectives. In: Brade H, Opal SM, Vogel SN, Morrison DC. (eds) Endotoxin in Health and Disease. Basel: Marcel Dekker, 1999, 1-30.
2. Pfeiffer R. Untersuchungen über das Choleragift. Z Hygiene 1892; 11: 393-412.
3. Rietschel ET, Cavaillon JM. Endotoxin and anti-endotoxin. Part 1. The contribution of the schools of Koch and Pasteur: life, milestone-experiments and concepts of Richard Pfeiffer (Berlin) and Alexandre Besredka (Paris). J Endotoxin Res 2002; 8: 3-16.
4. Rietschel ET, Cavaillon JM. Endotoxin and anti-endotoxin. Part 2. The contribution of the schools of Koch and Pasteur: life, milestone-experiments and concepts of Richard Pfeiffer (Berlin) and Alexandre Besredka (Paris). J Endotoxin Res 2002; 8: 71-82.
5. Westphal O, Lüderitz O. Chemische Erforshung von Lipopolysacchariden Gram-negativer Bakterien. Angew Chemie 1956; 66: 407-417.
6. Lüderitz O, Galanos C, Risse H et al. Structural relationships of Salmonella O and R antigens. Ann NY Acad Sci 1966; 133: 349-357.
7. Kim YB, Watson DW. Biologically active endotoxins from Salmonella mutants deficient in O- and R-polysaccharides and heptose. J Bacteriol 1967; 94: 1320-1326.
8. Kasai N, Nowotny A. Endotoxic glycolipid from a heptoseless mutant of Salmonella minnesota. J Bacteriol 1967; 94: 1824-1836.
9. Galanos C. Physical state and biological activity of lipopolysaccharides. Toxicity and immunogenicity of the lipid A component. Z Immunitatsforsch Exp Klin Immunol 1975; 149: 214-229.
10. Takayama K, Qureshi N, Mascagni P. Complete structure of lipid A obtained from the lipopolysaccharides of the heptoseless mutant of Salmonella typhimurium. J Biol Chem 1983; 258: 12801-12803.
11. Imoto M, Yoshimura H, Kusumoto S, Shiba T. Total synthesis of lipid A, active principle of bacterial endotoxin. Proc Jpn Acad Sci 1984; 60: 285-288.
12. Heppner G, Weiss DW. High susceptibility of strain A mice to endotoxin and endotoxin-red blood cell mixtures. J Bacteriol 1965; 90: 696-703.
13. Coutinho A, Forni L, Melchers F, Watanabe T. Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide. Eur J Immunol 1977; 7: 325-328.
14. Coutinho A, Meo T. Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice. Immunogenetics 1978; 7: 17-24.
15. Michalek SM, Moore RN, McGhee JR, Rosenstreich DL, Mergenhagen SE. The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin. J Infect Dis 1980; 141: 55-63.
16. Moore RN, Goodrum KJ, Berry LJ. Mediation of an endotoxic effect by macrophages. J Reticuloendothel Soc 1976; 19: 187-197.
17. Freudenberg MA, Keppler D, Galanos C. Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin. Infect Immun 1986; 51: 891-895.
18. Beutler B, Milsark IW, Cerami A. Passive immunization against cachectin/tumor necrosis factor (TNF) protects mice from the lethal effect of endotoxin. Science 1985; 229: 869-871.
19. Shakhov AN, Collart MA, Vassalli P, Nedospasov SA, Jongeneel CV. kappaB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages. J Exp Med 1990; 171: 35-47.
20. Geppert TD, Whitehurst CE, Thompson P, Beutler B. LPS signals activation of TNF biosynthesis through the RAS/RAF1/MEK/MAPK pathway. Mol Med 1994; 1: 93-103.
21. Han J, Lee JD, Bibbs L, Ulevitch RJ. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994; 265: 808-811.
22. Kyriakis JM, Banerjee P, Nikolakaki et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 1994; 369: 156-160.
23. Sanchez I, Hughes RT, Mayer BJ et al. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 1994; 372: 794-798.
24. Qu JM, Leaver HA, Aldhous MC, Yap PL. The effect of endotoxin lipopolysaccharide from different bacterial species on the generation of intracellular inositol trisphosphate and superoxide in a human phagocytic cell line. FEMS Microbiol Immunol 1990; 2: 279-283.
25. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990; 249: 1431-1433.
26. Haziot A, Reffero E, Konygen F et al. Resistance to endotoxin shock and reduced dissemination of Gram-negative bacteria in CD14-deficient mice. Immunity 1996; 4: 407-414.
27. Poltorak A, Smirnova I, He XL et al. Genetic and physical mapping of the Lps locus - identification of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis 1998; 24: 340-355.
28. Poltorak A, He XL, Smirnova I et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-2088.
29. Poltorak A, Merlin T, Nielsen PJ et al. A point mutation in the IL-12rbeta2 gene underlies the IL-12 unresponsiveness of LPS-defective c57bl/10ScCr mice. J Immunol 2001; 167: 2106-2111.
30. Yaegashi Y, Nielsen P, Sing A, Galanos C, Freudenberg MA. Interferon beta, a cofactor in the interferon gamma production induced by Gram-negative bacteria in mice. J Exp Med 1995; 181: 953-960.
31. Muller I, Freudenberg M, Kropf P, Kiderlen A-F, Galanos C. Leishmania major infection in C57BL/10 mice differing at the Lps locus: a new non-healing phenotype. Med Microbiol Immunol (Berl) 1997; 186: 75-81.
32. Merlin T, Sing A, Nielsen PJ, Galanos C, Freudenberg MA. Inherited IL-12 unresponsiveness contributes to the high LPS resistance of the Lps(d) C57BL/10ScCr mouse. J Immunol 2001; 166: 566-573.
33. Yang R-B, Mark MR, Gray A et al. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signaling. Nature 1998; 395: 284-288.
34. Kirschning CJ, Wesche H, Merrill AT, Rothe M. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med 1998; 188: 2091-2097.
35. Takeuchi O, Hoshino K, Kawai T et al. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 1999; 11: 443-451.
36. Hoshino K, Takeuchi O, Kawai T et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999; 162: 3749-3752.
37. Hayashi F, Smith KD, Ozinsky A et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001; 410: 1099-1103.
38. Hemmi H, Takeuchi O, Kawai T et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000; 408: 740-745.
39. Bauer S, Kirschning CJ, Hacker H et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 2001; 98: 9237-9242.
40. Fitzgerald KA, Palsson-McDermott EM, Bowie AG et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 2001; 413: 78-83.
41. Horng T, Barton GM, Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2001; 2: 835-841.
42. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999; 11: 115-122.
43. Anderson KV, Jurgens G, Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 1985; 42: 779-789.
44. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette Spatzle/Toll/Cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86: 973-983.
45. Levashina EA, Langley E, Green C et al. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science 1999; 285: 1917-1919.
46. Michel T, Reichhart JM, Hoffmann JA, Royet J. Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 2001; 414: 756-759.
47. Tauszig-Delamasure S, Bilak H, Capovilla M, Hoffmann JA, Imler JL. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. Nat Immunol 2002; 3: 91-97.
48. Ramet M, Manfruelli P, Pearson A, Mathey-Prevot B, Ezekowitz RA. Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 2002; 416: 644-648.
49. Poltorak A, Ricciardi-Castagnoli P, Citterio A, Bender B. Physical contact between LPS and Tlr4 revealed by genetic complementation. Proc Natl Acad Sci USA 2000; 97: 2163-2167.
50. Lien E, Means TK, Heine H et al. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest 2000; 105: 497-504.
51. Shimazu R et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999; 189: 1777-1782.
52. Suzuki N, Suzuki S, Duncan GS et al. Severe impairment of interleukin-1 and Toll-like receptor signaling in mice lacking IRAK-4. Nature 2002; 416: 750-756.
53. Brown SD, Peters J. Combining mutagenesis and genomics in the mouse - closing the phenotype gap. Trends Genet 1996; 12: 433-435.