Regulation of ion channels by integrins

Cell Biochemistry and Biophysics

Volumn 36, Issue 1, 2002, Pages 41-66

  Davis, Michael J ^a   Wu, Xin ^a   Nurkiewicz, Timothy R ^a   Kawasaki, Junya ^a   Gui, Peichun ^a   Hill, Michael A ^b   Wilson, Emily ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b RMIT UNIVERSITY   (Australia)

Author keywords

AKAP; Cytoskeleton; FAK; Focal adhesion; Growth factor receptors; Integrins; Nonreceptor tyrosine kinase; Receptor tyrosine kinase; Scaffolding proteins; SH3; Src

Indexed keywords

CALCIUM; INTEGRIN; ION; POTASSIUM;

ANIMAL; BIOLOGICAL MODEL; CELL DIVISION; CYTOSKELETON; EXTRACELLULAR MATRIX; HUMAN; METABOLISM; REVIEW;

ANIMALS; CALCIUM; CELL DIVISION; CYTOSKELETON; EXTRACELLULAR MATRIX; HUMANS; INTEGRINS; IONS; MODELS, BIOLOGICAL; POTASSIUM;

EID: 0036371648     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/CBB:36:1:41     Document Type: Review

References (186)

1. Davis, M. J., Wu, X., Nurkiewicz, T. R., Kawasaki, J., Gui, P., Hill, M. A., et al. (2001) Regulation of ion channels by protein tyrosine phosphorylation. Am. J. Physiol, 281, H1835-H1862.
2. Ismailov, I. I. and Benos, D. J. (1995) Effects of phosphorylation on ion channel function. Kidney Int. 48, 1167-1179.
3. Levitan, I. B. (1999) Modulation of ion channels by protein phosphorylation - how the brain works. Adv. Second Messenger Phosphoprotein Res. 33, 3-22.
4. Siegelbaum, S. A. (1994) Channel regulation: ion channel control by tyrosine phosphorylation. Curr. Biol. 4, 242-245.
5. Tsunoda, Y. (1998) Receptor-operated calcium influx mediated by protein tyrosine kinase pathways. J. Recept. Signal Transduct. Res. 18, 281-310.
6. Jonas, E. A. and Kaczmarek, L. K. (1996) Regulation of potassium channels by protein kinases. Curr. Opin. Neurobiol. 6, 318-323.
7. Levitan, I. B. (1994) Modulation of ion channels by protein phosphorylation and dephosphorylation. Annu. Rev. Physiol. 56, 193-212.
8. Pollock, J. D., Krempin, M., and Rudy, B. (1990) Differential effects of NGF, FGF, EGF, cAMP, and dexamethasone on neurite outgrowth and sodium channel expression in PC12 cells. J. Neurosci. 10, 2626-2637.
9. 2+ channels in rat embryo motoneurons by BDNF. Eur. J. Neurosci. 11, 1127-1133.
10. Fantl, W. J., Johnson, D. E., and Williams, L. T. (1993) Signalling by receptor tyrosine kinases. Annu. Rev. Biochem. 62, 453-481.
11. Abram, C. L. and Courtneidge, S. A. (2000) Src family tyrosine kinases and growth factor signaling. Exp. Cell Res. 254, 1-13.
12. Okada, M. and Nakagawa, H. (1989) A protein tyrosine kinase involved in regulation of pp60c-src function. J. Biol. Chem. 264, 20,886-20,893.
13. Schlaepfer, D. D., Hauck, C. R., and Sieg, D. J. (1999) Signaling through focal adhesion kinase. Prog. Biophys. Mol. Biol. 71, 435-478.
14. Vuori, K. (1998) Integrin signaling: tyrosine phosphorylation events in focal adhesions. J. Membr. Biol. 165, 191-199.
15. van der Flier, A. and Sonnenberg, A. (2001) Function and interactions of integrins. Cell Tissue Res. 305, 285-298.
16. Clark, E. A. and Brugge, J. S. (1995) Integrins and signal transduction pathways: the road taken. Science 268, 233-239.
17. Miyamoto, S., Teramoti, H., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K., et al. (1995) Integrin function: molecular hierarchies of cytoskeletal, and signaling molecules. J. Cell Biol. 131, 791-805.
18. Schaller, M. D., Hildebrand, J. D., Shannon, J. D., Fox, J. W., Vines, R. R., and Parsons, J. T. (1994) Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol. Cell. Biol. 14, 1680-1688.
19. Schlaepfer, D. D., Hanks, S. K., Hunter, T., and van der Geer, P. (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-791.
20. Cas) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs. J. Biol. Chem. 272, 5501-5509.
21. Chen, K. D., Li, Y. S., Kim, M., Li, S., Yuan, S., Chien, S., et al. (1999) Mechanotransduction in response to shear stress - roles of receptor tyrosine kinases, integrins, and Shc. J. Biol. Chem. 274, 18,393-18,400.
22. Miyamoto, S., Teramoto, H., Gutkind, J. S., and Yamada, K. M. (1996) Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol. 135, 1633-1642.
23. Arcangeli, A., Becchetti, A., Mannini, A., Mugnai, G., DeFilippi, P., Tarone, G., et al. (1993) Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels. J. Cell Biol. 122, 1131-1143.
24. + channels. J. Biol. Chem. 273, 34,696-34,702.
25. Ivanina, T., Neusch, C., Li, Y. X., Tong, Y., Labarca, C., Mosher, D. F., et al. (2000) Expression of GIRK (Kir3.1/Kir3.4) channels in mouse fibroblast cells with and without β1 integrins. FEBS Lett. 466, 327-332.
26. 3 integrin in the preosteoclastic leukemia cell line FLG 29.1. J. Biol. Chem. 276, 4923-4931.
27. 4 integrin and endothelial human CLCA2 mediate lung metastasis. J. Biol. Chem. 276, 25,438-25,446.
28. v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion. J. Biol. Chem. 269, 11,133-11,137.
29. 2+ influx in pulmonary endothelial cells. Circ. Res. 86, 456-462.
30. McNamee, H. P., Ingber, D. E., and Schwartz, M. A. (1993) Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J. Cell Biol. 121, 673-678.
31. Chenu, C., Colucci, S., Grano, M., Zigrino, P., Barattolo, R., Zambonin, G., et al. (1994) Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated infracellular signaling in human osteoclast-like cells. J. Cell Biol. 127, 1149-1158.
32. Shankar, G., Davison, I., Helfrich, M. H., Mason, W. T., and Horton, M. A. (1993) Integrin receptor-mediated mobilisation of intranuclear calcium in rat osteoclasts. J. Cell Sci. 105, 61-68.
33. i in rat osteoclasts and mouse-derived osteoclast-like cells. Am. J. Physiol. 266, C376-C381.
34. 2+ signalling through leukocyte CD11b/CD18 integrin. Biochem. J. 288, 465-473.
35. Nebe, B., Rychly, J., Knopp, A., and Bolm, W. (1995) Mechanical induction of beta-1-integrin-mediated calcium signaling in a hepatocyte cell line. Exp. Cell Res. 218, 479-484.
36. 2+ in renal vascular smooth muscle cells. Am. J. Physiol. 280, C593-C603.
37. 3- and store-independent calcium influx. Mol. Biol. Cell 7, 1025-1041.
38. Chen, B. M. and Grinnell, A. D. (1995) Integrins and modulation of transmitter release from motor nerve terminals by stretch. Science 269, 1578-1580.
39. 2+ dependence, and biophysical properties of integrin-mediated mechanical modulation of transmitter release from frog motor nerve terminals. J. Neurosci. 17, 904-916.
40. + current. Proc. R. Soc. Lond. (Biol.) 248, 235-240.
41. + channels in arteriolar vasodilation mediated by integrin interaction with RGD-containing peptide. Am. J. Physiol. 275, H1449-H1454.
42. Waitkus-Edwards, K. R., Martinez-Lemus, L. A., Wu, X., Trzciakowski, J. P., Davis, G. E., Davis, M. J., et al. (2001) α4β1 integrin activation of L-type calcium channels in vascular smooth muscle causes arteriolar vasoconstriction. Circ. Res., in press.
43. Tsai, W., Morielli, A. D., Cachero, T. G., and Peralta, E. G. (1999) Receptor protein tyrosine phosphatase α participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity. EMBO J. 18, 109-118.
44. + and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and betal integrins. J. Exp. Med. 191, 1167-1176.
45. 2+ entry in human THP-1 monocytes. Am. J. Physiol. 279, C488-C494.
46. + currents in monocytes by VCAM-1 and E-selectin on activated human endothelium. Am. J. Physiol. 275, C267-C277.
47. FAK and associated proteins: role in neuritogenesis. Biochem. Biophys. Res. Commun. 210, 823-829.
48. 1 integrin as a chondrocyte mechanoreceptor. J. Orthop. Res. 15, 742-747.
49. Salter, D. M., Robb, J. E., and Wright, M. O. (1997) Electrophysiological responses of human bone cells to mechanical stimulation: evidence for specific integrin function in mechanotransduction. J. Bone Miner. Res. 12, 1133-1141.
50. Millward-Sadler, S. J., Wright, M. O., Lee, H.-S., Nishida, K., Caldwell, H., Nuki, G., et al. (1999) Integrin-regulated secretion of interleukin 4: a novel pathway of mechanotransduction in human articular chondrocytes. J. Cell Biol. 145, 183-189.
51. Arcangeli, A., Becchetti, A., Del Bene, M. R., Wanke, E., and Olivotto, M. (1991) Fibronectin-integrin binding promotes hyperpolarization of murine erythroleukemia cells. Biochem. Biophys. Res. Commun. 177, 1266-1272.
52. Millward-Sadler, S. J., Wright, M. O., Lee, H., Caldwell, H., Nuki, G., and Salter, D. M. (2000) Altered electrophysiological responses to mechanical stimulation and abnormal signailing through α5β1 integrin in chondrocytes from osteoarthritic cartilage. Osteoarthritis Cartilage 8, 272-278.
53. Millward-Sadler, S. J., Wright, M. O., Lee, H., Nishida, K., Caldwell, H., Nuki, G., et al. (1999) Integrin-regulated secretion of interleukin 4: a novel pathway of mechanotransduction in human articular chondrocytes. J. Cell Biol. 145, 183-189.
54. Lee, H. S., Millward-Sadler, S. J., Wright, M. O., Nuki, G., and Salter, D. M. (2000) Integrin and mechanosensitive ion channel-dependent tyrosine phosphorylation of focal adhesion proteins and β-catenin in human articular chondrocytes after mechanical stimulation. J. Bone Miner. Res. 15, 1501-1509.
55. Schwartz, M. A. (1993) Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular-free calcium. J. Cell Biol. 120, 1003-1010.
56. Fujimoto, T., Fujimura, K., and Kuramoto, A. (1991) Electrophysiological evidence that gly-coprotein IIb-IIIa complex is involved in calcium channel activation on human platelet plasma membrane. J. Biol. Chem. 266, 16,370-16,375.
57. 2+ signaling. Proc. Natl. Acad. Sci. USA 91, 8214-8218.
58. Bertolino, G., Noris, P., Spedini, P., and Balduini, C. L. (1995) Ristocetin-induced platelet agglutination stimulates GPIIb/IIIa-dependent calcium influx. Thromb. Haemost. 73, 689-692.
59. 1 integrin ligands. J. Cell Biol. 143, 241-252.
60. 1 integrin requires signaling between focal adhesion proteins. J. Biol. Chem. 276, 30, 285-30,292.
61. Kwon, M. S., Park, C. S., Choi, K., Ahnn, J., Kim, J. I., Eom, S. H., et al. (2000) Calreticulin couples calcium release and calcium influx in integrin-mediated calcium signaling. Mol. Biol. Cell 11, 1433-1443.
62. 2-adrenoceptor signalling in cat atrial myocytes. J. Physiol. (Lond.) 527 Pt 1, 3-9.
63. 2+ current in cat atrial myocytes. J. Physiol. (Lond.) 526 (Pt. 1), 57-68.
64. Wildering, W. C., Lodder, J. C., Kits, K. S., and Bulloch, A. G. (1995) Nerve growth factor (NGF) acutely enhances high-voltage-activated calcium currents in molluscan neurons. J. Neurophysiol. 74, 2778-2781.
65. Sjaastad, M. D. and Nelson, W. J. (1997) Integrin-mediated calcium signaling and regulation of cell adhesion by intracellular calcium. BioEssays 19, 47-55.
66. 3 integrin mediate enhanced tyrosine phosphorylation of multiple proteins in adherent bovine pulmonary artery endothelial cells. J. Biol. Chem. 270, 16,781-16,787.
67. Hoth, M. and Penner, R. (1992) Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 355, 353-356.
68. Montell, C. and Rubin, G. M. (1989) Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 2, 1313-1323.
69. Peng, J. B., Chen, X. Z., Berger, U. V., Vassilev, P. M., Tsukaguchi, H., Brown, E. M., et al. (1999) Molecular cloning and chanracterization of a channel-like transporter mediating intestinal calcium absorption. J. Biol. Chem. 274, 22,739-22,746.
70. Yue, L., Peng, J. B., Hediger, M. A., and Clapham, D. E. (2001) CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature 410, 705-709.
71. Parekh, A. B. and Penner, R. (1997) Store depletion and calcium influx. Physiol. Rev. 77, 901-930.
72. Montell, C. (1999) Visual transduction in Drosophila. Annu. Rev. Cell. Dev. Biol. 15, 231-268.
73. Philipp, S., Trost, C., Warnat, J., Rautmann, J., Himmerkus, N., Schroth, G., et al. (2000) TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells. J. Biol. Chem. 275, 23,965-23,972.
74. 2+-permeable cation channel. Circ. Res. 88, 325-332.
75. Kawasaki, J., Nurkiewicz, T. R., and Davis, M. J. (2001) Regulation of endothelial cell calcium current by αvβ3 integrin. FASEB J. 15, A109 (abstract).
76. Sharma, N. R. and Davis, M. J. (1996) Calcium entry activated by store depletion in coronary endothelium is promoted by tyrosine phosphorylation. Am. J. Physiol. 270, H267-H274.
77. 2+ entry? Trends Pharmacol. Sci. 15, 282.
78. 2+ entry in human platelets. FEBS Lett. 315, 242-246.
79. 2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets. J. Biol. Chem. 268, 18,151-18,156.
80. Rosado, J. A., Jenner, S., and Sage, S. O. (2000) A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling. J. Biol. Chem. 275, 7527-7533.
81. Rosado, J. A. and Sage, S. O. (2000) The actin cytoskeleton in store-mediated calcium entry. J. Physiol. (Lond.) 526, 221-229.
82. Djouder, N., Prepens, U., Aktories, K., and Cavalie, A. (2000) Inhibition of calcium release-activated calcium current by Rac/Cdc42-inactivating clostridial cytotoxins in RBL cells. J. Biol. Chem. 275, 18,732-18,738.
83. Miyamoto, S., Akiyama, S. K., and Yamada, K. M. (1995) Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267, 883-885.
84. Waitkus, K. R., Davis, G. E., and Meininger, G. A. (1998) Collagen proteolysis and vasodilation in isolated rat cremaster arterioles. FASEB J. 12, A384 (abstract).
85. Wijetunge, S., Lymn, J. S., and Hughes, A. D. (1998) Effect of inhibition of tyrosine phosphatases on voltage-operated calcium channel currents in rabbit isolated ear artery cells. Br. J. Pharmacol. 124, 307-316.
86. c-src increases voltage-operated calcium channel currents in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 217, 1039-1044.
87. Wijetunge, S. and Hughes, A. D. (1996) Activation of endogenous c-Src or a related tyrosine kinase by intracellular (PY)EEI peptide increases voltage-operated calcium channel currents in rabbit ear artery cells. FEBS Lett. 399, 63-66.
88. 2+ channels in rabbit colonic smooth muscle cells by c-Src and focal adhesion kinase. J. Biol. Chem. 273, 5337-5342.
89. Wijetunge, S. and Hughes, A. D. (1995) Effect of platelet-derived growth factor on voltage-operated calcium channels in rabbit isolated ear artery cells. Br. J. Pharmacol. 115, 534-538.
90. Blair, L. A. and Marshall, J. (1997) IGF-1 modulates N and L calcium channels in a PI 3-kinase-dependent manner. Neuron 19, 421-429.
91. Selinfreund, R. H. and Blair, L. A. (1994) Insulin-like growth factor-I induces a rapid increase in calcium currents and spontaneous membrane activity in clonal pituitary cells. Mol. Pharmacol. 45, 1215-1220.
92. Bence-Hanulec, K. K., Marshall, J., and Blair, L. A. (2000) Potentiation of neuronal L calcium channels by IGF-1 requires phosphorylation of the α1 subunit on a specific tyrosine residue. Neuron 27, 121-131.
93. (IC) subunit of L-type calcium channels and the role of a proline-rich domain in membrane tethering of proteolytic fragments. J. Biol. Chem. 275, 8556-8563.
94. 2+ channel activity by deletions at the carboxyl terminus of the cardiac alpha 1 subunit. J. Biol. Chem. 269, 1635-1640.
95. 3 integrin mediates arteriolar vasodilation in response to RGD peptides. Circ. Res. 79, 821-826.
96. D'Angelo, G., Davis, M. J., and Meininger, G. A. (1997) Calcium and mechanotransduction of the myogenic response. Am. J. Physiol. 273, H175-H182.
97. Davis, G. E., Bayless, K. J., Davis, M. J., and Meininger, G. A. (2000) Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules. Am. J. Pathol. 156, 1489-1498.
98. i proteins. J. Cell Biol. 154, 753-761.
99. Gurubhagavatula, I., Amrani, Y., Pratico, D., Ruberg, F. L., Albelda, S. M., Panettieri, R. A., Jr. (1998) Engagement of human PECAM-1 (CD31) on human endothelial cells increases intracellular calcium ion concentration and stimulates prostacyclin release. J. Clin. Invest. 101, 212-222.
100. O'Brien, C. D., Ji, G., Wang, Y. X., Sun, J., Krymskaya, V. P., Ruberg, F. L., et al. (2001) PECAM-1 (CD31) engagement activates a phosphoinositide- independent, nonspecific cation channel in endothelial cells. FASEB J. 15, 1257-1260.
101. Erickson, H. P. (1993) Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions. Curr. Opin. Cell Biol. 5, 869-876.
102. Srinivasan, J., Schachner, M., and Catterall, W. A. (1998) Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R. Proc. Natl. Acad. Sci. USA 95, 15,753-15,757.
103. Isom, L. L., Ragsdale, D. S., De Jongh, K. S., Westenbroek, R. E., Reber, B. F., Scheuer, T., et al. (1995) Structure and function of the β2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell 83, 433-442.
104. Ricard, J., Giudici-Orticoni, M. T., and Gontero, B. (1994) The modulation of enzyme reaction rates within multi-enzyme complexes. 1. Statistical thermodynamics of information transfer through multi-enzyme complexes. Eur. J. Biochem. 226, 993-998.
105. Xu, X. Z., Choudhury, A., Li, X., and Montell, C. (1998) Coordination of an array of signaling proteins through homo- and heteromeric inter-actions between PDZ domains and target proteins. J. Cell Biol. 142, 545-555.
106. Colledge, M. and Scott, J. D. (1999) AKAPs: from structure to function. Trends Cell Biol. 9, 216-221.
107. + channel through the GK domain. EMBO J. 19, 78-83.
108. 2+ channel assembled in a signaling complex by the PDZ domain protein INAD is phosphorylated through the interaction with protein kinase C (ePKC). FEBS Lett. 425, 317-322.
109. Gray, P. C., Scott, J. D., and Catterall, W. A. (1998) Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins. Curr. Opin. Neurobiol. 8, 330-334.
110. Dodge, K. and Scott, J. D. (2000) AKAP79 and the evolution of the AKAP model. FEBS Lett. 476, 58-61.
111. Johnson, B. D. (1999) The company they keep: ion channels and their intracellular regulatory partners. Adv. Second Messenger Phosphoprotein Res. 33, 203-228.
112. Wang, W. (1999) Regulation of the ROMK channel: interaction of the ROMK with associate proteins. Am. J. Physiol. 277, F826-F831.
113. 2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron 19, 185-196.
114. 2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase. Proc. Natl Acad. Sci. USA 91, 11,492-11,496.
115. Ca channels expressed in mammalian cells by direct phosphorylation at serine 1072. J. Biol. Chem. 274, 10,927-10,935.
116. Ca channels in airway smooth muscle cells by endogenous protein kinase A. Am. J. Physiol. 271, L100-L105.
117. Sun, F., Hug, M. J., Bradbury, N. A., and Frizzell, R. A. (2000) Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin. J. Biol. Chem. 275, 14,360-14,366.
118. Ingber, D. E. (1993) Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton. J. Cell Sci. 104, 613-627.
119. Molday, L. L., Cook, N. J., Kaupp, U. B., and Molday, R. S. (1990) The cGMP-gated cation channel of bovine rod photoreceptor cells is associated with a 240-kDa protein exhibiting immunochemical cross- reactivity with spectrin. J. Biol. Chem. 265, 18,690-18,695.
120. Lue, R. A., Marfatia, S. M., Branton, D., and Chishti, A. H. (1994) Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc. Natl Acad. Sci. USA 91, 9818-9822.
121. Zuckerman, J. B., Chen, X., Jacobs, J. D., Hu, B., Kleyman, T. R., and Smith, P. R. (1999) Association of the epithelial sodium channel with Apx and α-spectrin in A6 renal epithelial cells. J. Biol. Chem. 274, 23,286-23,295.
122. van Rossum, D., Kuhse, J., and Betz, H. (1999) Dynamic interaction between soluble tubulin and C-terminal domains of N-methyl-D-aspartate receptor subunits. J. Neurochem. 72, 962-973.
123. Wyszynski, M., Lin, J., Rao, A., Nigh, E., Beggs, A. H., Craig, A. M., et al. (1997) Competitive binding of α-actinin and calmodulin to the NMDA receptor. Nature 385, 439-442.
124. Sheng, M. and Pak, D. T. (2000) Ligand-gated ion channel interactions with cytoskeletal and signaling proteins. Annu. Rev. Physiol. 62, 755-778.
125. Sheng, M. and Wyszynski, M. (1997) Ion channel targeting in neurons. Bioessays 19, 847-853.
126. Colledge, M. and Froehner, S. C. (1998) Signals mediating ion channel clustering at the neuromuscular junction. Curr. Opin. Neurobiol 8, 357-363.
127. Petrecca, K., Miller, D. M., and Shrier, A. (2000) Localization and enhanced current density of the kv4.2 potassium channel by interaction with the actin-binding protein filamin. J. Neurosci. 20, 8736-8744.
128. + channel by β subunit. Modulation by a phosphorylation-dependent interaction between the distal C terminus of α subunit and cytoskeleton. J. Biol. Chem. 272, 14,021-14,024.
129. + channel β-subunits with cytoskeleton is mediated by unique amino terminal domains. J. Mol. Neurosci. 11, 199-208.
130. + channel alpha subunit modulates the inactivation conferred by a beta subunit. Involvement of cytoskeleton. J. Biol. Chem. 271, 29,321-29,328.
131. Maruoka, N. D., Steele, D. F., Au, B. P., Dan, P., Zhang, X., Moore, E. D., et al. (2000) α-Actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells. FEBS Lett. 473, 188-194.
132. Maguire, G., Connaughton, V., Prat, A. G., Jackson, G. R., Jr., and Cantiello, H. F. (1998) Actin cytoskeleton regulates ion channel activity in retinal neurons. Neuroreport 9, 665-670.
133. 2+ channel current in cultured vascular smooth muscle cells. Am. J. Physiol. 279, C480-C487.
134. Maltsev, V. A. and Undrovinas, A. I. (1997) Cytoskeleton modulates coupling between availability and activation of cardiac sodium channel. Am. J. Physiol. 273, H1832-H1840.
135. 2+ transient in rat ventricular cardiomyocytes: an effect of altered actin cytoskeleton? J. Mol. Cell. Cardiol. 30, 1665-1670.
136. + - channel inactivation. Proc. Natl. Acad. Sci. USA 89, 10,910-10,914.
137. Fincham, V. J., Unlu, M., Brunton, V. G., Pitts, J. D., Wyke, J. A., and Frame, M. C. (1996) Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins. J. Cell Biol. 135, 1551-1564.
138. 60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated platelets. J. Biol. Chem. 266, 15,705-15,709.
139. Weernink, P. A. and Rijksen, G. (1995) Activation and translocation of c-Src to the cytoskeleton by both platelet-derived growth factor and epidermal growth factor. J. Biol. Chem. 270, 2264-2267.
140. Holmes, T. C., Fadool, D. A., and Levitan, I. B. (1996) Tyrosine phosphorylation of the Kv1.3 potassium channel. J. Neurosci. 16, 1581-1590.
141. Bowlby, M. R., Fadool, D. A., Holmes, T. C., and Levitan, I. B. (1997) Modulation of the Kv1.3 potassium channel by receptor tyrosine kinases. J. Gen. Physiol. 110, 601-610.
142. Holmes, T. C., Fadool, D. A., Ren, R. B., and Levitan, I. B. (1996) Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science 274, 2089-2091.
143. + channel in the presence of Src tyrosine kinase. J. Biol. Chem. 275, 30,683-30,689.
144. Srinivasan, Y., Elmer, L., Davis, J., Bennett, V., and Angelides, K. (1988) Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. Nature 333, 177-180.
145. Lambert, S., Davis, J. Q., and Bennett, V. (1997) Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. J. Neurosci. 17, 7025-7036.
146. G is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. J. Cell Biol. 143, 1295-1304.
147. Kaplan, M. R., Meyer-Franke, A., Lambert, S., Bennett, V., Duncan, I. D., Levinson, S. R., et al. (1997) Induction of sodium channel clustering by oligodendrocytes. Nature 386, 724-728.
148. B knockout mice. Circ. Res. 86, 441-447.
149. Bennett, P. B. (2000) Anchors a weigh! Ion channels, cytoskeletal proteins, and cellular excitability. Circ. Res. 86, 367-368.
150. Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science 279, 509-514.
151. Dransfield, D. T., Bradford, A. J., Smith, J., Martin, M., Roy, C., Mangeat, P. H., et al. (1997) Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. EMBO J. 16, 35-43.
152. Niggli, V., Andreoli, C., Roy, C., and Mangeat, P. (1995) Identification of a phosphatidylinositol-4,5-bisphosphate-binding domain in the N-terminal region of ezrin. FEBS Lett. 376, 172-176.
153. Hunter, T. and Cooper, J. A. (1981) Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell 24, 741-752.
154. Mackay, D. J., Esch, F., Furthmayr, H., and Hall, A. (1997) Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins. J. Cell Biol. 138, 927-938.
155. Machesky L. M. and Hall, A. (1997) Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization. J. Cell Biol. 138, 913-926.
156. Boudreau, J. and Jones, P. L. (1999) Extracellular matrix and integrin signalling: the shape of things to come. Biochem. J. 339, 481-488.
157. Schoenwaelder, S. M. and Burridge, K. (1999) Bidirectional signaling between the cytoskeleton and integrins. Curr. Opin. Cell Biol. 11, 274-286.
158. Wilk-Blaszczak, M. A., Singer, W. D., Quill, T., Miller, B., Frost, J. A., Sternweis, P. C., et al. (1997) The monomeric G-proteins Rac1 and/or Cdc42 are required for the inhibition of voltage-dependent calcium current by bradykinin. J. Neurosci. 17, 4094-4100.
159. Giancotti, F. G. and Ruoslahti, E. (1999) Integrin signaling. Science 285, 1028-1032.
160. Ekinci, F. J., Malik, K. U., and Shea, T. B. (1999) Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to β-amyloid. MAP kinase mediates
161. 2+ channel activation by platelet-derived growth factor-induced tyrosine phosphorylation and Ras guanine triphosphate-binding proteins in rat glomerular mesangial cells. J. Clin. Invest. 97, 2332-2341.
162. Collin, C., Papageorge, A. G., Lowy, D. R., and Alkon, D. L. (1990) Early enhancement of calcium current by H-ras oncoproteins injected into Hermissenda neurons. Science 250, 1743-1745.
163. 2+ current density in embryonic chick dorsal root ganglion neurons. Eur. J. Neurosci. 4, 361-368.
164. Hescheler, J., Klinz, F. J., Schultz, G., and Wittinghofer, A. (1991) Ras proteins activate calcium channels in neuronal cells. Cell Signal. 3, 127-133.
165. Hemmick, L. M., Perney, T. M., Flamm, R. E., Kaczmarek, L. K., and Birnberg, N. C. (1992) Expression of the H-ras oncogene induces potassium conductance and neuron-specific potassium channel mRNAs in the AtT20 cell line. J. Neurosci. 12, 2007-2014.
166. Flamm, R. E., Birnberg, N. C., and Kaczmarek, L. K. (1990) Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium current. Pflügers Arch. 416, 120-125.
167. + channels. Cell 61, 769-776.
168. + channel currents. Science 255, 192-194.
169. + channels. J. Biol. Chem. 266, 22,222-22,226.
170. Hilborn, M. D., Vaillancourt, R. R., and Rane, S. G. (1998) Growth factor receptor tyrosine kinases acutely regulate neuronal sodium channels through the src signaling pathway. J. Neurosci. 18, 590-600.
171. Fitzgerald, E. M. and Dolphin, A. C. (1997) Regulation of rat neuronal voltage-dependent calcium channels by endogenous p21-ras. Eur. J. Neurosci. 9, 1252-1261.
172. Galli, A. and DeFelice, L. J. (1994) Inactivation of L-type Ca channels in embryonic chick ventricle cells: dependence on the cytoskeletal agents colchicine and taxol. Biophys. J. 67, 2296-2304.
173. 2+. Neuron 10, 797-804.
174. 2+ current in rat ventricular myocytes. J. Physiol. (Lond.) 516, 409-419.
175. Ingber, D. E. (1997) Tensegrity: the architectural basis of cellular mechanotransduction. Annu. Rev. Physiol. 59, 575-599.
176. Machu, T. K. (1998) Colchicine competitively antagonizes glycine receptors expressed in Xenopus oocytes. Neuropharmacology 37, 391-396.
177. Rasenick, M. M., Stein, P. J., and Bitensky, M. W. (1981) The regulatory subunit of adenylate cyclase interacts with cytoskeletal components. Nature 294, 560-562.
178. Wang, N., Butler, J. P., and Ingber, D. E. (1993) Mechanotransduction across the cell surface and through the cytoskeleton. Science 260, 1124-1127.
179. Schmidt, C., Pommerenke, H., Dürr, F., Nebe, B., and Rychly J. (1998) Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins. J. Biol. Chem. 273, 5081-5085.
180. Intengan, H. D. and Schiffrin, E. L. (2000) Structure and mechanical properties of resistance arteries in hypertension: role of adhesion molecules and extracellular matrix determinants. Hypertension 36, 312-318.
181. Bezie, Y., Lamaziere, J. M., Laurent, S., Challande, P., Cunha, R. S., Bonnet, J., et al. (1998) Fibronectin expression and aortic wall elastic modulus in spontaneously hypertensive rats. Arteriosclerosis Thromb. Vasc. Biol. 18, 1027-1034.
182. Magnusson, M. K. and Mosher, D. F. (1998) Fibronectin - structure, assembly, and cardiovascular implications. Arteriosclerosis Thromb. Vasc. Biol. 18, 1363-1370.
183. Yu, G., Zou, H., Prewitt, R. L., and Hill, M. A. (1999) Impaired arteriolar mechanotransduction in experimental diabetes mellitus. J. Diabetes Complications 13, 235-242.
184. Nilius, B. and Droogmans, G. (2001) Ion channels and their functional role in vascular endothelium. Physiol. Rev. 81, 1415-1459.
185. Intengan, H. D., Thibault, G., Li, J. S., and Schiffrin, E. L. (1999) Resistance artery mechanics, structure, and extracellular components in spontaneously hypertensive rats: effects of angiotensin receptor antagonism and converting enzyme inhibition. Circulation 100, 2267-2275.
186. Wildering, N. C., Hermann, P. M., and Bulloch, A. G. M. (2002) Rapid neuromodulatory actions of integrin ligands. J. Neurosci., in press.