메뉴 건너뛰기




Volumn 8, Issue 4, 2000, Pages 272-278

Altered electrophysiological responses to mechanical stimulation and abnormal signalling through α5β1 integrin in chondrocytes from osteoarthritic cartilage

Author keywords

Chondrocytes; Integrin; Mechanotransduction; Osteoarthritis

Indexed keywords

INTEGRIN;

EID: 0033858860     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1999.0301     Document Type: Article
Times cited : (89)

References (53)
  • 1
    • 0007106833 scopus 로고
    • Ways of cartilage breakdown in human and experimental osteoarthrosis
    • G. Nuki. London: Pitman Medical
    • Meachim G. Ways of cartilage breakdown in human and experimental osteoarthrosis. Nuki G. The Aetiopathogenesis of Osteoarthrosis. 1980;16-28 Pitman Medical, London.
    • (1980) The Aetiopathogenesis of Osteoarthrosis , pp. 16-28
    • Meachim, G.1
  • 2
    • 0026536919 scopus 로고
    • Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures
    • Mow VC, Ratcliffe A, Poole AR. Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures. Biomaterials. 13:1992;67-97.
    • (1992) Biomaterials , vol.13 , pp. 67-97
    • Mow, V.C.1    Ratcliffe, A.2    Poole, A.R.3
  • 3
    • 0003079057 scopus 로고    scopus 로고
    • Role of mechanical factors in the aetiology, pathogenesis and progression of osteoarthritis
    • J.Y. Register, J.P. Pelletier, J.M. Pelletier, & Y.H. Henrotin. New York: Springer
    • Nuki G. Role of mechanical factors in the aetiology, pathogenesis and progression of osteoarthritis. Register JY, Pelletier JP, Pelletier JM, Henrotin YH. Experimental and Clinical Aspects of Osteoarthritis. 1999;Springer, New York.
    • (1999) Experimental and Clinical Aspects of Osteoarthritis
    • Nuki, G.1
  • 4
    • 0000119113 scopus 로고
    • Effect of motion and load on articular cartilage in animal models
    • K.E. Kuettner, R. Schleyerbach, J.G. Peyron, & V.C. Hascall. New York: Raven Press
    • Helminen HJ, Kiviranta I, Saamanem AM. Effect of motion and load on articular cartilage in animal models. Kuettner KE, Schleyerbach R, Peyron JG, Hascall VC. Articular Cartilage and Osteoarthritis. 1992;501-510 Raven Press, New York.
    • (1992) Articular Cartilage and Osteoarthritis , pp. 501-510
    • Helminen, H.J.1    Kiviranta, I.2    Saamanem, A.M.3
  • 6
    • 0024670466 scopus 로고
    • Biochemical changes in articular cartilage after joint immobilization by casting or external fixation
    • Behrens F, Kraft EL, Oegema TR Jr. Biochemical changes in articular cartilage after joint immobilization by casting or external fixation. J Orthop Res. 7:1989;335-343.
    • (1989) J Orthop Res , vol.7 , pp. 335-343
    • Behrens, F.1    Kraft, E.L.2    Oegema T.R., Jr.3
  • 7
    • 0030923695 scopus 로고    scopus 로고
    • Immobilisation causes long lasting matrix changes both in the immobilised and contralateral joint cartilage
    • Jortikka MO, Inkinen RI, Tammi MI, Parkkinen JJ, Haapala J, Kiviranta I. Immobilisation causes long lasting matrix changes both in the immobilised and contralateral joint cartilage. Ann Rheum Dis. 56:1997;255-261.
    • (1997) Ann Rheum Dis , vol.56 , pp. 255-261
    • Jortikka, M.O.1    Inkinen, R.I.2    Tammi, M.I.3    Parkkinen, J.J.4    Haapala, J.5    Kiviranta, I.6
  • 8
    • 0026354379 scopus 로고
    • Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament
    • Brandt KD, Myers SL, Burr D, Albrecht M. Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament. Arthritis Rheum. 34:1991;1560-1570.
    • (1991) Arthritis Rheum , vol.34 , pp. 1560-1570
    • Brandt, K.D.1    Myers, S.L.2    Burr, D.3    Albrecht, M.4
  • 9
    • 0025811018 scopus 로고
    • Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection
    • Adams ME, Brandt KD. Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection. J Rheumatol. 18:1991;428-435.
    • (1991) J Rheumatol , vol.18 , pp. 428-435
    • Adams, M.E.1    Brandt, K.D.2
  • 10
    • 0002125217 scopus 로고
    • Effects of static and dynamic compression on matrix metabolism in cartilage explants
    • K.E. Kuettner, R. Schleyerbach, J.G. Peyron, & V.C. Hascall. New York: Raven Press
    • Sah RL-Y, Grodzinsky AJ, Plaas AHK, Samay JD. Effects of static and dynamic compression on matrix metabolism in cartilage explants. Kuettner KE, Schleyerbach R, Peyron JG, Hascall VC. Articular Cartilage and Osteoarthritis. 1992;373-392 Raven Press, New York.
    • (1992) Articular Cartilage and Osteoarthritis , pp. 373-392
    • Sah, R.-Y.1    Grodzinsky, A.J.2    Plaas, A.H.K.3    Samay, J.D.4
  • 11
    • 0028062112 scopus 로고
    • The chondrocyte: A cell under pressure
    • Urban JPG. The chondrocyte: a cell under pressure. Br J Rheumatol. 33:1994;901-908.
    • (1994) Br J Rheumatol , vol.33 , pp. 901-908
    • Urban, J.P.G.1
  • 12
    • 0029411806 scopus 로고
    • Effects of fluid-induced shear on articular chondrocyte morphology and metabolism in vitro
    • Smith RL, Donlon BS, Gupta MK, Mohtai M, Das P, Carter DR. Effects of fluid-induced shear on articular chondrocyte morphology and metabolism in vitro. J Orthop Res. 13:1995;824-831.
    • (1995) J Orthop Res , vol.13 , pp. 824-831
    • Smith, R.L.1    Donlon, B.S.2    Gupta, M.K.3    Mohtai, M.4    Das, P.5    Carter, D.R.6
  • 13
    • 0030032790 scopus 로고    scopus 로고
    • The effects of intermittent pressurisation on the electrophysiology of cultured human chondrocytes: Evidence for the presence of stretch activated membrane ion channels
    • Wright MO, Jopanbutra P, Bavington C, Salter DM, Nuki G. The effects of intermittent pressurisation on the electrophysiology of cultured human chondrocytes: evidence for the presence of stretch activated membrane ion channels. Clin Science. 90:1996;61-71.
    • (1996) Clin Science , vol.90 , pp. 61-71
    • Wright, M.O.1    Jopanbutra, P.2    Bavington, C.3    Salter, D.M.4    Nuki, G.5
  • 14
    • 0031229569 scopus 로고    scopus 로고
    • Hyperpolarisation of cultured human chondrocytes following cyclical pressurisation involves α5β1 integrin and integrin-associated intracellular pathways
    • Wright MO, Godolphin JL, Dunne E, Bavington C, Jopanbutra P, Nuki G. Hyperpolarisation of cultured human chondrocytes following cyclical pressurisation involves α5β1 integrin and integrin-associated intracellular pathways. J Orth Res. 15:1997;742-747.
    • (1997) J Orth Res , vol.15 , pp. 742-747
    • Wright, M.O.1    Godolphin, J.L.2    Dunne, E.3    Bavington, C.4    Jopanbutra, P.5    Nuki, G.6
  • 15
    • 0000857839 scopus 로고    scopus 로고
    • Accelerated proteoglycan synthesis in human chondrocytes following cyclical pressurisation is mediated by β1 integrin and stretch activated ion channels
    • Bavington C, Wright MO, Jobanputra P, Lin H, Morrison PT, Brennan FR. Accelerated proteoglycan synthesis in human chondrocytes following cyclical pressurisation is mediated by β1 integrin and stretch activated ion channels. Br J Rheumatol. 35:1996;110.
    • (1996) Br J Rheumatol , vol.35 , pp. 110
    • Bavington, C.1    Wright, M.O.2    Jobanputra, P.3    Lin, H.4    Morrison, P.T.5    Brennan, F.R.6
  • 17
    • 0030846728 scopus 로고    scopus 로고
    • Intermittent cyclic loading of cartilage explants modulates fibronectin metabolism
    • Steinmeyer J, Ackermann B, Raiss RX. Intermittent cyclic loading of cartilage explants modulates fibronectin metabolism. Osteoarthritis Cartilage. 5:1997;331-341.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 331-341
    • Steinmeyer, J.1    Ackermann, B.2    Raiss, R.X.3
  • 18
    • 0031558755 scopus 로고    scopus 로고
    • The proteoglycan metabolism of mature bovine articular cartilage explants superimposed to continuously applied cyclic mechanical loading
    • Steinmeyer J, Knue S. The proteoglycan metabolism of mature bovine articular cartilage explants superimposed to continuously applied cyclic mechanical loading. Biochem Biophys Res Commun. 240:1997;216-221.
    • (1997) Biochem Biophys Res Commun , vol.240 , pp. 216-221
    • Steinmeyer, J.1    Knue, S.2
  • 19
    • 0031890531 scopus 로고    scopus 로고
    • Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants
    • Quinn TM, Grodzinsky AJ, Buschmann MD, Kim Y-J, Hunziker EB. Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants. J Cell Sci. 1111:1998;573-583.
    • (1998) J Cell Sci , vol.1111 , pp. 573-583
    • Quinn, T.M.1    Grodzinsky, A.J.2    Buschmann, M.D.3    Kim, Y.-J.4    Hunziker, E.B.5
  • 20
    • 0026484088 scopus 로고
    • Response of Plasma membrane to applied hydrostatic pressure in chondrocytes and fibroblasts
    • Wright MO, Stockwell RA, Nuki G. Response of Plasma membrane to applied hydrostatic pressure in chondrocytes and fibroblasts. Connect Tiss Res. 28:1992;49-70.
    • (1992) Connect Tiss Res , vol.28 , pp. 49-70
    • Wright, M.O.1    Stockwell, R.A.2    Nuki, G.3
  • 21
    • 0030965776 scopus 로고    scopus 로고
    • Electrophysiological responses of human bone cells to mechanical stimulation: Evidence for specific integrin function in mechanotransduction
    • Salter DM, Robb JE, Wright MO. Electrophysiological responses of human bone cells to mechanical stimulation: evidence for specific integrin function in mechanotransduction. J Bone and Min Res. 12:1997;1133-1141.
    • (1997) J Bone and Min Res , vol.12 , pp. 1133-1141
    • Salter, D.M.1    Robb, J.E.2    Wright, M.O.3
  • 22
    • 0000771125 scopus 로고
    • Sulphate uptake by chondrocytes in relation to histological changes in osteo-arthritic human articular cartilage
    • Collins DH, McElligott TF. Sulphate uptake by chondrocytes in relation to histological changes in osteo-arthritic human articular cartilage. Ann Rheum Dis. 19:1960;318-330.
    • (1960) Ann Rheum Dis , vol.19 , pp. 318-330
    • Collins, D.H.1    McElligott, T.F.2
  • 23
    • 0021751197 scopus 로고
    • Isoquinoline sulphonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase
    • Hidaka H, Inagaki M, Kawamoto S, Sasak Y. Isoquinoline sulphonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase. C Biochem. 23:1984;5036-5041.
    • (1984) C Biochem , vol.23 , pp. 5036-5041
    • Hidaka, H.1    Inagaki, M.2    Kawamoto, S.3    Sasak, Y.4
  • 25
    • 0024550448 scopus 로고
    • Calphostin C (UCN-1028C), a novel microbial compound is a highly potent and specific inhibitor of protein kinase C
    • Kobayashi E, Nakomo H, Morimoto M, Tamaoki T. Calphostin C (UCN-1028C), a novel microbial compound is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 159:1989;548-553.
    • (1989) Biochem Biophys Res Commun , vol.159 , pp. 548-553
    • Kobayashi, E.1    Nakomo, H.2    Morimoto, M.3    Tamaoki, T.4
  • 26
    • 0021981584 scopus 로고
    • Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase
    • Cockcroft S, Gomperts BD. Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase. Nature. 314:1985;534-536.
    • (1985) Nature , vol.314 , pp. 534-536
    • Cockcroft, S.1    Gomperts, B.D.2
  • 29
    • 0023849740 scopus 로고
    • Voltage-gated sodium and calcium currents in rat osteoblasts
    • Chesnoy-Marchais D, Fritsch J. Voltage-gated sodium and calcium currents in rat osteoblasts. J Physiol. 398:1988;291-311.
    • (1988) J Physiol , vol.398 , pp. 291-311
    • Chesnoy-Marchais, D.1    Fritsch, J.2
  • 30
    • 0022994018 scopus 로고
    • +channels of small conductance in cultured rat skeletal muscle
    • +channels of small conductance in cultured rat skeletal muscle. Nature. 323:1986;718-720.
    • (1986) Nature , vol.323 , pp. 718-720
    • Blatz, A.L.1    Magleby, K.L.2
  • 31
    • 0024539514 scopus 로고
    • Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions
    • Yang XC, Sachs F. Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science. 243:1989;1068-1071.
    • (1989) Science , vol.243 , pp. 1068-1071
    • Yang, X.C.1    Sachs, F.2
  • 32
    • 0018611301 scopus 로고
    • Substoichiometric concentrations of cytochalasin D inhibit actin polymerisation
    • Brenner SL, Korn ED. Substoichiometric concentrations of cytochalasin D inhibit actin polymerisation. J Biol Chem. 254:1979;9982-9985.
    • (1979) J Biol Chem , vol.254 , pp. 9982-9985
    • Brenner, S.L.1    Korn, E.D.2
  • 33
    • 0343632596 scopus 로고    scopus 로고
    • Mechanical stimulation of human articular chondrocyte aggrecan and matrix metalloproteinase 3 mRNA levels is mediated via integrins and interleukin 4. (Abstract)
    • Millward Sadler SJ, Wright MO, Nuki G, Salter DM. Mechanical stimulation of human articular chondrocyte aggrecan and matrix metalloproteinase 3 mRNA levels is mediated via integrins and interleukin 4. (Abstract). Osteoarthritis and Cartilage. 7:1999.
    • (1999) Osteoarthritis and Cartilage , vol.7
    • Millward Sadler, S.J.1    Wright, M.O.2    Nuki, G.3    Salter, D.M.4
  • 34
    • 0000857839 scopus 로고    scopus 로고
    • Accelerated proteoglycan synthesis in human chondrocytes following cyclical pressurisation is mediated by β1 integrin and stretch activated ion channels. (Abstract)
    • Bavington C, Wright MO, Jobanputra P, Lin H, Morrison PT, Brennan FR. Accelerated proteoglycan synthesis in human chondrocytes following cyclical pressurisation is mediated by β1 integrin and stretch activated ion channels. (Abstract). Br J Rheumatol. 35:1996;110.
    • (1996) Br J Rheumatol , vol.35 , pp. 110
    • Bavington, C.1    Wright, M.O.2    Jobanputra, P.3    Lin, H.4    Morrison, P.T.5    Brennan, F.R.6
  • 35
    • 0032233894 scopus 로고    scopus 로고
    • Salter DM Immunohistochemistry in the study of normal and osteoarthritic human articular cartilage
    • Ostergaard K. Salter DM Immunohistochemistry in the study of normal and osteoarthritic human articular cartilage. Progr Histochem Cytochem. 33:1998;93-168.
    • (1998) Progr Histochem Cytochem , vol.33 , pp. 93-168
    • Ostergaard, K.1
  • 37
    • 0031857773 scopus 로고    scopus 로고
    • Expression of α- And β-subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral heads
    • Ostergaard K, Salter DM, Petersen J, Bendtzen K, Hvolris J, Andersen CB. Expression of α- and β-subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral heads. Annals of Rheum Dis. 57:1998;303-308.
    • (1998) Annals of Rheum Dis , vol.57 , pp. 303-308
    • Ostergaard, K.1    Salter, D.M.2    Petersen, J.3    Bendtzen, K.4    Hvolris, J.5    Andersen, C.B.6
  • 38
    • 0028988155 scopus 로고
    • Expression of beta 1 integrins by cultured articular chondrocytes and in osteoarthritic cartilage
    • Loeser RF, Carlson CS, McGee MP. Expression of beta 1 integrins by cultured articular chondrocytes and in osteoarthritic cartilage. Exp Cell Res. 217:1995;248-257.
    • (1995) Exp Cell Res , vol.217 , pp. 248-257
    • Loeser, R.F.1    Carlson, C.S.2    McGee, M.P.3
  • 40
    • 0030697844 scopus 로고    scopus 로고
    • CD44 expression is up-regulated in the deep zone of osteoarthritic cartilage from human femoral heads
    • Ostergaard K, Salter DM, Andersen CB, Petersen J, Bendtzen K. CD44 expression is up-regulated in the deep zone of osteoarthritic cartilage from human femoral heads. Histopathology. 31:1997;451-459.
    • (1997) Histopathology , vol.31 , pp. 451-459
    • Ostergaard, K.1    Salter, D.M.2    Andersen, C.B.3    Petersen, J.4    Bendtzen, K.5
  • 41
    • 0023616963 scopus 로고
    • An immunohistochemical study of fibronectin in human osteoarthritic and disease free articular cartilage
    • Jones KL, Brown M, Ali SY, Brown RA. An immunohistochemical study of fibronectin in human osteoarthritic and disease free articular cartilage. Ann Rheum Dis. 46:1987;809-815.
    • (1987) Ann Rheum Dis , vol.46 , pp. 809-815
    • Jones, K.L.1    Brown, M.2    Ali, S.Y.3    Brown, R.A.4
  • 42
    • 0029922580 scopus 로고    scopus 로고
    • Presence of ED-A containing fibronectin in human articular cartilage from patients with osteoarthritis and rheumatoid arthritis
    • Chevalier X, Claudepierre P, Groult N, Zardi L, Hornebeck W. Presence of ED-A containing fibronectin in human articular cartilage from patients with osteoarthritis and rheumatoid arthritis. J Rheumatol. 23:1996;1022-1030.
    • (1996) J Rheumatol , vol.23 , pp. 1022-1030
    • Chevalier, X.1    Claudepierre, P.2    Groult, N.3    Zardi, L.4    Hornebeck, W.5
  • 43
    • 0027292352 scopus 로고
    • Tenascin is increased in cartilage and synovium from arthritic knees
    • Salter DM. Tenascin is increased in cartilage and synovium from arthritic knees. Br J Rheumatol. 32:1993;780-786.
    • (1993) Br J Rheumatol , vol.32 , pp. 780-786
    • Salter, D.M.1
  • 44
    • 0033002731 scopus 로고    scopus 로고
    • Tenascin-C inhibits beta1 integrin-dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signalling mechanism
    • Probstmeier R, Pesheva P. Tenascin-C inhibits beta1 integrin-dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signalling mechanism. Glycobiology. 9:1999;101-114.
    • (1999) Glycobiology , vol.9 , pp. 101-114
    • Probstmeier, R.1    Pesheva, P.2
  • 45
    • 0027172919 scopus 로고
    • Mechanotransduction across the cell surface and through the cytoskeleton
    • Wang N, Butler JP, Ingber DE. Mechanotransduction across the cell surface and through the cytoskeleton. Science. 260:1993;1124-1127.
    • (1993) Science , vol.260 , pp. 1124-1127
    • Wang, N.1    Butler, J.P.2    Ingber, D.E.3
  • 46
    • 0030760119 scopus 로고    scopus 로고
    • Role of integrins in cellular responses to mechanical stress and adhesion
    • Shyy JY, Chien S. Role of integrins in cellular responses to mechanical stress and adhesion. Curr Opin Cell Biol. 9:1997;707-713.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 707-713
    • Shyy, J.Y.1    Chien, S.2
  • 47
    • 0031258760 scopus 로고    scopus 로고
    • Integrin signalling
    • Yamada KM. Integrin signalling. Matrix Biol. 16:1997;137-141.
    • (1997) Matrix Biol , vol.16 , pp. 137-141
    • Yamada, K.M.1
  • 48
    • 0030272735 scopus 로고    scopus 로고
    • Integrin cytoplasmic interactions and bidirectional transmembrane signalling
    • Dedhar S, Hannigan GE. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr Opin Cell Biol. 8:1996;657-669.
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 657-669
    • Dedhar, S.1    Hannigan, G.E.2
  • 49
    • 0030763495 scopus 로고    scopus 로고
    • Detection of interleukin 1 in the cartilage of patients with osteoarthritis: A possible autocrine/paracrine role in pathogenesis
    • Towle CA, Hung HH, Bonassar LJ, Treadwell BV, Mangham DC. Detection of interleukin 1 in the cartilage of patients with osteoarthritis: a possible autocrine/paracrine role in pathogenesis. Osteoarthritis Cartilage. 5:1997;293-300.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 293-300
    • Towle, C.A.1    Hung, H.H.2    Bonassar, L.J.3    Treadwell, B.V.4    Mangham, D.C.5
  • 50
    • 0026021223 scopus 로고
    • Production of cytokines by chondrocytes and its role in proteoglycan degradation
    • Shinmei M, Masuda K, Kikuchi T, Shimomura Y, Okada Y. Production of cytokines by chondrocytes and its role in proteoglycan degradation. J Rheumatol. 27:1991;89-91.
    • (1991) J Rheumatol , vol.27 , pp. 89-91
    • Shinmei, M.1    Masuda, K.2    Kikuchi, T.3    Shimomura, Y.4    Okada, Y.5
  • 51
    • 0030885574 scopus 로고    scopus 로고
    • Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex
    • Clancy RM, Rediske J, Tang X, Nijher N, Frenkel S, Philips M. Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. J Clin Invest. 100:1997;1789-1796.
    • (1997) J Clin Invest , vol.100 , pp. 1789-1796
    • Clancy, R.M.1    Rediske, J.2    Tang, X.3    Nijher, N.4    Frenkel, S.5    Philips, M.6
  • 52
    • 0020771754 scopus 로고
    • Osteoarthrosis in runners with knee pain
    • McDermott M, Freyne P. Osteoarthrosis in runners with knee pain. Br J Sports Med. 17:1983;84-87.
    • (1983) Br J Sports Med , vol.17 , pp. 84-87
    • McDermott, M.1    Freyne, P.2
  • 53
    • 0025905636 scopus 로고
    • Anterior (cranial) cruciate ligament transection in the dog: A bona fide model of osteoarthritis, not merely of cartilage injury and repair
    • Brandt KD, Braunstein EM, Visco DM, O'Connor B, Heck D, Albrecht M. Anterior (cranial) cruciate ligament transection in the dog: a bona fide model of osteoarthritis, not merely of cartilage injury and repair. J Rheumatol. 18:1991;436-446.
    • (1991) J Rheumatol , vol.18 , pp. 436-446
    • Brandt, K.D.1    Braunstein, E.M.2    Visco, D.M.3    O'Connor, B.4    Heck, D.5    Albrecht, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.