Growth factor receptor tyrosine kinases acutely regulate neuronal sodium channels through the Src signaling pathway

Journal of Neuroscience

Volumn 18, Issue 2, 1998, Pages 590-600

  Hilborn, Michael D ^a   Vaillancourt, Richard R ^b   Rane, Stanley G ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Growth factor receptor tyrosine kinases; NGF; PC12 cells; PDGF receptors; Ras; Sodium channels; Src

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; NERVE GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; RAS PROTEIN; SODIUM CHANNEL; SODIUM ION;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; ELECTROPHYSIOLOGY; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SODIUM CURRENT;

EID: 0031972834     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-02-00590.1998     Document Type: Article

References (21)

1. Abe K, Xie F, Saito H (1991) Epidermal growth factor enhances shortterm potentiation and facilitates induction of long-term potentiation in rat hippocampal slices. Brain Res 547:171-174.
2. Bailey CH, Kaang B, Chen M, Martin KC, Lim C, Casadio A, Kandel ER (1997) Mutation in the phosphorylation sites of MAP kinase blocks learning-related internalization of apCAM in Aplysia sensory neurons. Neuron 18:839-842.
3. Bilder GE, Krawiec JA, McVety K, Gazit A, Gilon C, Lyall R, Zilberstcin A, Levitzki A, Perrone MH, Schreiber AB (1991) Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells. Am J Physiol 260:C721-C730.
4. Bothwell M (1995) Functional interactions of neurotrophins and neurotrophin receptors. Annu Rev Neurosci 18:223-253.
5. Cavalić A, Berninger B, Haas CA, García DE, Lindholm D, Lux HD (1994) Constitutive upregulation of calcium channel currents in rat phaeochromocytoma cells: role of c-fos and c-jun. J Physiol (Lond) 479:11-27.
6. Chao MV (1992) Growth factor signaling: where is the specificity? Cell 68:995-997.
7. Claesson-Welsh L (1994) Platelet-derived growth factor receptor signals. J Biol Chem 269:32023-32026.
8. Cowley S, Paterson H, Kemp P, Marshall CJ (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
9. Cukierman S (1996) Regulation of voltage-dependent sodium channels. J Membr Biol 151:203-214.
10. D'Arcangelo G, Halegoua S (1993) A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, Raf-mediated gene induction. Mol Cell Biol 13:3146-3155.
11. + channel. Neuron 6:165-175.
12. + currents in mouse neuroblastoma cells. J Membr Biol 140:101-110.
13. + currents by enhancing inactivation from the closed state. Pflügers Arch 429:245-252.
14. Greene LA, Tischler AS (1982) PC12 pheochromocytoma cells in neurobiology research. Adv Cell Neurobiol 3:373-414.
15. Heasley LE, Johnson GL (1992) The β-PDGF receptor induces neuronal differentiation of PC12 cells. Mol Biol Cell 3:545-553.
16. Johnson GL, Vaillancourt RR (1994) Sequential protein kinase reactions controlling cell growth and differentiation. Curr Opin Cell Biol 6:230-238.
17. Kaiman D, Wong B, Horvai AE, Cline MJ, O'Lague PH (1990) Nerve growth factor acts through cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells. Neuron 2:355-366.
18. Kang H, Schuman EM (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267:1658-1662.
19. Kaplan DR, Stephens RM (1994) Neurotrophin signal transduction by the Trk receptor. J Neurobiol 25:1404-1417.
20. Keegan K, Halegoua S (1993) Signal transduction pathways in neuronal differentiation. Curr Opin Neurobiol 3:14-19.
21. Levitzki A, Gazit A (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267:1782-1788.