Engagement of human PECAM-1 (CD31) on human endothelial cells increases intracellular calcium ion concentration and stimulates prostacyclin release

Journal of Clinical Investigation

Volumn 101, Issue 1, 1998, Pages 212-222

  Gurubhagavatula, Indira ^a   Amrani, Yassine ^a   Pratico, Domenico ^a   Ruberg, Frederick L ^a   Albelda, Steven M ^a   Panettieri Jr , Reynold A ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Antibody cross linking; Cell adhesion molecules; Cell signaling; Cell cell interactions; Inflammation

Indexed keywords

CD31 ANTIGEN; MONOCLONAL ANTIBODY; PROSTACYCLIN;

ARTICLE; BLOOD VESSEL TONE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL COMMUNICATION; CELL INTERACTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN CROSS LINKING; VASCULAR ENDOTHELIUM;

EID: 0031964675     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI269     Document Type: Article

References (42)

1. Graier, W.F., M. Sturek, and W.R. Kukovetz. 1994. Calcium regulation and endothelial vascular function. Endothelium. 1:223-236.
2. Himmel, H.M., A.R. Whorton, and H.C. Strauss. 1993. Intracellular calcium, currents, and stimulus-response coupling in endothelial cells. Hypertension. 21:112-127.
3. Hattori, R., K.K. Hamilton, R.D. Fugate, R.P. McEver, and P.J. Sims. 1989 Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140. J. Biol. Chem. 264:7768-7771.
4. Bennett, J., and A. Weeds. 1986. Calcium and the cytoskeleton. Br. Med. Bull. 42:385-390.
5. Lum, H., P.J. del Vecchio, A.S. Schneider, M.S. Goligorsky, and A.B. Malik. 1989. Calcium dependence of the thrombin-induced increase in endothelial albumin permeability. J. Appl. Physiol. 66:1471-1476.
6. Lum, H., and A.B. Malik. 1994. Regulation of vascular endothelial barrier function. Am. J. Physiol. 267:L223-L241.
7. Wysolmerski, R.B., and D. Lagunoff. 1990. Involvement of myosin light-chain kinase in endothelial cell retraction. Proc. Natl. Acad. Sci. USA. 87:16-20.
8. He, P., S.M. Pogakis, and F.E. Curry. 1990. Measurement of cytoplasmic calcium in single microvessels with increased permeability. Am. J. Physiol. 258: H1366-H1374.
9. Huang, A.J., J.E. Manning, T.M. Bandak, M.C. Tatau, K.R. Hanser, and S.C. Silverstein. 1993. Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells. J. Cell Biol. 120:1371-1380.
10. Schimmenti, L.A., H.C. Yan, J.A. Madri, and S.M. Albelda. 1992. Platelet-endothelial cell adhesion molecule. PECAM-1, modulates cell migration. J. Cell Physiol. 153:417-428.
11. DeLisser, H.M., M. Christofidou-Solomidou, R.M. Strieter, M.D. Burdick, C.S. Robinson, R.S. Wexler, J.S. Kerr, C. Garlanda, J. Merwin, J. Madri, et al. 1997. Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am. J. Pathol. 151:671-677.
12. Ferrero, E., M.E. Ferrero, R. Pardi, and M.R. Zocchi. 1995. The platelet endothelial cell adhesion molecule-1 (PECAM1) contributes to endothelial barrier function. FEBS Lett. 374:323-326.
13. Muller, W.A., S.A. Weigl, X. Deng, and D.M. Phillips. 1993. PECAM-1 is required for transendothelial migration of leukocytes. J. Exp. Med. 178:449-460.
14. Poggi, A., M.C. Panzeri, L. Moretta, and M.R. Zocchi. 1996. CD31-triggered rearrangement of the actin cytoskeleton in human natural killer cells. Euir. J. Immunol. 26:817-824.
15. 2, integrin activation. J. Immunol. 156:1515-1524.
16. Vaporicyan, A.A., H.M. DeLisser, H.C. Yan, I.I. Mendiguren, S.R. Thom, M.L. Jones, P.A. Ward, and S.M. Albelda. 1993. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science. 262:1580-1582.
17. DeLisser, H.M., P.J. Newman, and S.M. Albelda. 1994. Molecular and functional aspects of PECAM-1/CD31. Immunol. Today. 15:490-495.
18. Newman, P.J. 1997. The biology of PECAM-1. J. Clin. Invest. 99:3-8.
19. Deaglio, S., U. Dianzai, A.L. Horenstein, J.E. Fernandez, C. van Kooten, M. Bragardo, A. Funaro, G. Garbarino, F. Di Virgilio, J. Banchereau, et al. 1996. Human CD38 ligand. A 120-KDA protein predominantly expressed on endothelial cells. J. Immunol. 156:727-734.
20. Yan, H.C., J.M. Pilewski, Q. Zhang, H.M. DeLisser, L. Romer, and S.M. Albelda. 1995. Localization of multiple functional domains on human PECAM-1 (CD31) by monoclonal antibody epitope mapping. Cell Adhes. Commun. 3:45-66.
21. Albelda, S.M., W.A. Muller, C.A. Buck, and P.J. Newman. 1991. Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J. Cell Biol. 114:1059-1068.
22. Albelda, S.M., M. Daise, E.M. Levine, and C.A. Buck. 1989. Identification and characterization of cell-substratum adhesion receptors on cultured human endothelial cells. J. Clin. Invest. 83:1992-2002.
23. Smythe, W.R., H.C. Hwang, K.M. Amin, S.L. Eck, B.L. Davidson, J.M. Wilson, L.R. Kaiser, and S.M. Albelda. 1994. Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVTk) gene to thoracic neoplasms: an effective in vitro drug sensitization system. Cancer Res. 54:2055-2059.
24. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 545 pp.
25. DeLisser, H.M., J. Chilkotowsky, H.C. Yan, M.L. Daise, C.A. Buck, and S.M. Albelda. 1994. Deletions in the cytoplasmic domain of platelet-endothelial cell adhesion molecule (PECAM-1, CD31) result in changes in ligand binding properties. J. Cell Biol 124:195-203.
26. Sun, J., J. Williams, H.C. Yan, K.M. Amin. S.M. Albelda, and H.M. DeLisser. 1996. Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression. J. Biol. Chem. 271:18561-18570.
27. Panettieri, R.A., Jr., I.P. Hall, C.S. Maki, and R.K. Murray. 1995. α-thrombin increases cytosolic calcium and induces human airway smooth muscle cell proliferation. Am. J. Respir. Cell Mol. Biol. 13:205-216.
28. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450.
29. Pratico, D., J.A. Lawson, and G.A. FiltzGerald. 1995. Cyclooxygenase-dependent formation of the isoprostane, 8-epi prostaglandin F2 alpha. J. Biol. Chem. 270:9800-9808.
30. 2+ mobilization in human umbilical-vein endothelial cells stimulated by thrombin and histamine. Biochem. J. 256:371-376.
31. Ryan, U.S., P.V. Avdonin, E.Y.A. Posin, E.G., Popov, S.M. Danilov, and V.A. Tkachuk. 1988. Influence of vasoactive agents on cytoplasmic free calcium in vascular endothelial cells. J. Appl. Physiol. 65:2221-2227.
32. Birch, K.A., B.M. Ewenstein, D.E. Golan, and J.S. Pober. 1994. Prolonged peak elevations in cytoplasmic free calcium ions, derived from intracellular stores, correlate with the extent of thrombin-stimulated exocytosis in single human umbilical vein endothelial cells. J. Cell Physiol. 160:545-554.
33. Muller, W.A., and S.A. Weigl. 1992. Monocyte-selective transendothelial migration: dissection of the binding and transmigration phases by an in vitro assay. J. Exp. Med. 176:819-828.
34. Jackson, D.E., C.M. Ward, R. Wang, and P.J. Newman. 1997. The protein tyrosine phosphatase, SHP-2, binds PECAM-1 and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1 and integrin-mediated cellular signaling. J. Biol. Chem. 272: 6986-6993.
35. Spinozzi, F., E. Agea, O. Bistoni, S. Belia, A. Travetti, R. Gerli, C. Muscat, and A. Bertotto. 1995. Intracellular calcium levels are differentially regulated in T lymphocytes triggered by anti-CD2 and anti-CD3 monoclonal antibodies. Cell. Signal. 7:287-293.
36. lck in Jurkat T cell line. J. Exp. Med. 179:1747-1756.
37. Itoh, K., H. Kawamura, and H. Asou. 1992. A novel monoclonal antibody against carbohydrates of L1 cell adhesion molecule causes an influx of calcium in cultured cortical neurons. Brain Res. 580:233-240.
38. Hallam, T.J., R. Jacob, and J.E. Merritt. 1988. Evidence that agonists stimulate bivalent-cation influx into human endothelial cells. Biochem. J. 255: 179-184.
39. Buchan, K.W., and W. Martin. 1991. Bradykinin induces elevations of cytosolic calcium through mobilisation on intracellular and extracellular pools in bovine aortic endothelial cells. Br. J. Pharmacol. 102:35-40.
40. 2+-entry in endothelial cells. Role of intracellular calcium pool. Am. J. Physiol. 262:C171-C181.
41. Lu, T.T., L.G. Yan, and J.A. Madri. 1996. Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1. Proc. Natl. Acad. Sci. USA. 93:11808-11813.
42. Sun, Q.H., H.M. DeLisser, M.M. Zukowski, C. Paddock, S.M. Albelda, and P.J. Newman. 1996. Individually distinct Ig-homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity. J. Biol. Chem. 271: 11090-11098.