cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits

Neuron

Volumn 19, Issue 1, 1997, Pages 185-196

  Gao, Tianyan ^a   Yatani, Atsuko ^b   Dell'Acqua, Mark L ^c   Sako, Hidenori ^b   Green, Stuart A ^b   Dascal, Nathan ^d   Scott, John D ^c   Hosey, M Marlene ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BETA ADRENERGIC RECEPTOR; CALCIUM CHANNEL; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN SUBUNIT; SERINE;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; EMBRYO; GENE EXPRESSION; GENE MUTATION; HEART MUSCLE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0030760304     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80358-X     Document Type: Article

References (39)

1. Carr, D.W., and Scott, J.D. (1992). Blotting and band-shifting: techniques for studying protein-protein interactions. Trends Biochem. Sci. 17, 246-249.
2. Carr, D.W., Hausken, Z.E., Fraser, I.D., Stofko-Hahn, R.E., and Scott, J.D. (1992). Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J. Biol. Chem. 267, 13376-13382.
3. Chang, F.C., and Hosey, M.M. (1988). Dihydropyridine and phenylalkylamine receptors associated with cardiac and skeletal muscle calcium channels are structurally different. J. Biol. Chem. 263, 18929-18937.
4. 2+ channels. J. Biol. Chem. 270, 30036-30044.
5. 2a subunit and effects on channel function. J. Biol. Chem. 271, 26465-26468.
6. Coghlan, V.M., Hausken, Z.E., and Scott, J.D. (1995a). Subcellular targeting of kinases and phosphatases by association with bifunctional anchoring proteins. Biochem. Soc. Trans. 23, 592-596.
7. Coghlan, V.M., Perrino, B.A., Howard, M., Langeberg, L.K., Hicks, J.B., Gallatin, W.M., and Scott, J.D. (1995b). Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science 267, 108-111.
8. 1 subunit of the cardiac L-type calcium channel by adenosine 3′,5′-cyclic monophosphate-dependent protein kinase. Biochemistry 35, 10392-10402.
9. 2+ channels. J. Biol. Chem. 270, 12056-12064.
10. De Waard, M., Gurnett, C.A., and Campbell, K.P. (1996). Structural and functional diversity of voltage-activated calcium channels. Ion Channels 4, 41-87.
11. Faux, M.C., and Scott, J.D. (1996). Molecular glue: kinase anchoring and scaffold proteins. Cell 85, 9-12.
12. 2+ channels and adenylyl cyclase in cardiac myocytes. J. Biol. Chem., in press.
13. Gray, P.C., Tibbs, V.C., Catterall, W.A., and Murphy, B.J. (1997). Identification of a 15-kDa cAMP-dependent protein kinase-anchoring protein associated with skeletal muscle L-type calcium channels. J. Biol. Chem. 272, 6297-6302.
14. Hosey, M.M., Chien, A.J., and Puri, T.S. (1996). Structure and regulation of L-type calcium channels: a current assessment of the properties and roles of channel subunits. Trends Cardiovasc. Med. 6, 265-273.
15. 2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 91, 11492-11496.
16. 2+ channel by anchored cAMP-dependent protein kinase. J. Neurosci. 17, 1243-1255.
17. Klauck, T.M., Faux, M.C., Labudda, K., Langeberg, L.K., Jaken, S., and Scott, J.D. (1996). Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science 271, 1589-1592.
18. 2+ channels in mouse ventricular myocytes. Am. J. Physiol. 272, H606-H612.
19. McCartney, S., Little, B.M., and Scott, J.D. (1995a). Analysis of a novel A-kinase anchoring protein 100, (AKAP 100). Biochem. Soc. Trans. 23, 268S.
20. McCartney, S., Little, B.M., Langeberg, L.K., and Scott, J.D. (1995b). Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum. J. Biol. Chem. 270, 9327-9333.
21. McDonald, T.F., Pelzer, S., Trautwein, W., and Pelzer, D.J. (1994). Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol. Rev. 74, 365-507.
22. Mitterdorfer, J., Froschmayr, M., Grabner, M., Moebius, F.F., Glossmann, H., and Striessnig, J. (1996). Identification of PK-A phosphorylation sites in the carboxyl terminus of L-type calcium channel subunits. Biochemistry 35, 9400-9406.
23. Ndubuka, C., Li, Y., and Rubin, C.S. (1993). Expression of a kinase anchor protein 75 depletes type II cAMP-dependent protein kinases from the cytoplasm and sequesters the kinases in a participate pool. J. Biol. Chem. 268, 7621-7624.
24. Pals-Rylaarsdam, R., Xu, Y., Witt-Enderby, P., Benovic, J.L., and Hosey, M.M. (1995). Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms. J. Biol. Chem. 270, 29004-29011.
25. 1C subunit. FEBS Lett. 384, 189-192.
26. 1, and β subunits. J. Gen. Physiol. 105, 289-305.
27. Perez-Reyes, E., Castellano, A., Kim, H.S., Bertrand, P., Baggstrom, E., Lacerda, A.E., Wei, X.Y., and Birnbaumer, L. (1992). Cloning and expression of a cardiac/brain β subunit of the L-type calcium channel. J. Biol. Chem. 267, 1792-1797.
28. Perez-Reyes, E., Yuan, W., Wei, X., and Bers, D.M. (1994). Regulation of the cloned L-type cardiac calcium channel by cyclic-AMP-dependent protein kinase. FEBS Lett. 342, 119-123.
29. 2+ channels. Biochemistry, in press.
30. Richardson, R.M., and Hosey, M.M. (1992). Agonist-induced phosphorylation and desensitization of human m2muscarinic cholinergic receptors in Sf9 insect cells. J. Biol. Chem. 267, 22249-22255.
31. Rosenmund, C., Carr, D.W., Bergeson, S.E., Nilaver, G., Scott, J.D., and Westbrook, G.L. (1994). Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons. Nature 368, 853-856.
32. Singer-Lahat, D., Lotan, I., Biel, M., Flockerzi, V., Hofmann, F., and Dascal, N. (1994). Cardiac calcium channels expressed in Xenopus oocytes are modulated by dephosphorylation but not by cAMP-dependent phosphorylation. Recept. Channels 2, 215-226.
33. 2+ channel activity by deletions at the carboxyl terminus of the cardiac alpha 1 subunit. J. Biol. Chem. 269, 1635-1640.
34. 1 subunit interaction domain. J. Biol. Chem. 270, 18088-18093.
35. Yamamoto, S., Kuntzweiler, T.A., Wallick, E.T., Sperelakis, N., and Yatani, A. (1996). Amino acid substitutions in the Na/K-ATPase a1 subunit alter the cation regulation of pump current expressed in HeLa cells. J. Physiol. 495, 733-742.
36. 2+ channel. Circ. Res. 75, 315-323.
37. 2+ channels with β1-adrenoceptors. Circ. Res. 76, 335-342.
38. 2+ channel. FEBS Lett. 309, 343-349.
39. Zong, X., Schreieck, J., Mehrke, G., Welling, A., Schuster, A., Bosse, E., Flockerzi, V., and Hofmann, F. (1995). On the regulation of the expressed L-type calcium channel by cAMP-dependent phosphorylation. Pflügers Arch. 430, 340-347.