Regulation of potassium channels by protein kinases

Current Opinion in Neurobiology

Volumn 6, Issue 3, 1996, Pages 318-323

  Jonas, Elizabeth A ^a   Kaczmarek, Leonard K ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; POTASSIUM CHANNEL; PROTEIN KINASE; PROTEIN SERINE KINASE; TYROSINE;

DROSOPHILA; EXCITABILITY; KINETICS; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; REVIEW; XENOPUS;

EID: 0030176232     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(96)80114-0     Document Type: Article

References (45)

1. + channels expressed In a mammalian cell line and In ventricular myocytes by protein klnase C. Proc Natl Acad Sci USA 1994, 91:3289-3293.
2. Wesl JW, Numann R, Murphy BJ, Scheuer T, Catterall WAA phosphorylatlon site In the Na+ channel required for modulation by protein klnase C. Science 1991, 294:866-868.
3. Li M, Wast JW, Numann R, Murphy BJ, Scheuer T, Catterall WAConvergent regulation of sodium channels by protein klnase C and cAMP-dependent protein klnase. Science 1993, 261:1439-1442
4. 2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein klnase. Proc Natl Acad Sci USA 1994, 91:11492-11496. Voltage-dependent potentiation of L-type calcium currents requires phosphorylation of the calcium channel by PKA. This potenttation can be blocked by a peptide derived from a PKA-anchoring protein, suggesting that close physical proximity of the channel with the kinase is required for channel modulation.
5. Perez-Reyes E, Yuan W, Wei X, Bers DMRegulation of the cloned L-type cardiac calcium channel by cycllc-AMPdependent protein kinase. FEBS Lett 1994, 342:119-123.
6. Hell JW, Yokoyama CT, Breeze U, Chavkin C, Catterall WAPhosphorylatlon of preayneptle and postsynaptlc calcium channels by cAMP-dependent protein kinase In hippocampal neurons. EM BO J 1995, 14:3036-3044.
7. Selinfreund RH, Blair LACInsulin-Ilk growth factor-1 induces a rapid Increase in calcium currents and spontaneous membrane activity in clonal pituitary cells. Moi Pharmacol 1994, 45:1215-1220.
8. 2+ channels by protein kinase C during rapid formation of putative neuropeptide release sites In isolated Aptysin neurons. Neuron 1992, 8:863-889.
9. Jonas EA, Knox RJ, Kaczmarek LK. Schwaru JH. Solomon DH: Insulin receptor In Aplysio neurons: characterization, molecular cloning and modulation on ion currents. J Neurosci 1996, 16:1645-1658. Demonstration that an endogenous receptor tyrosine kinase in an Aplysia neuron acutely regulates potassium and calcium channels.
10. Chandy KG, Gutman GAVoltage-gated potassium channel genes. In CRC Handbook of Receptors and Channels. Boca Raton, Florida: CRC Press; 1995:1-71. A comprehensive review covering studies up to 1995 of the Shaker superfamily of channels.
11. Ganetzky B, Warmke JW, Robertson G, Pallanck LNew potassium gene families in flies and mammals: from mutants to molecules. Soc Gen Physiol Ser 1995, 50:29-39.
12. Ketchum KA, Joiner WJ, Sellers AJ. Kaczmarek LK, Goidstein SAN: A new family of outwardly rectifying potassium channel proteins with two pore domains In tandem. Nature 1995, 376:690-695
13. Kaczmarek LKProperties and regulation of the m in K potassium channel. Physiol Rev 1996, in press.
14. Rettig J, Heinemann SH, Wunder F, Lorra C, Parce] ON, Dolly JO, Pongs O: Inactlvation properties of voltage-gated K+ channels altered by presence of p-subunlt Nature 1994, 369:289-294.
15. Majumder K, Biasi MD, Wang Z, Wible BAMolecular cloning and functional expression of a novel potassium channel β-subunit from human atrium. FEBS Lett 1995, 361:13-16.
16. Hoshi T, Zagotta WN, Aldrich RWBiophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 1990, 250:533-538.
17. Zagotta WN, Hoshi T, Aldrich RWRestoration of inactivation in mutants of Shaker potassium channels by peptide derived from ShB. Science 1990, 250:568-571.
18. Marom S, Levitan IBState-dependent Inactivation ol the Kv3 potassium channel. Biophys J 1994, 67:579-589.
19. Covarrubias M, Wei A, Salkott L, Vyas TBElimination of rapid potassium channel inactivation by phosphorylation of the Inactivation gate. Neuron 1994,13:1403-1412. A dramatic example of how phosphorylation of sites on the ammo terminus of Ihe Kv3.4 channel converts it from a rapidly inactivating 'A-type' channel into a 'delayed rectifier' channel.
20. Blumenthal EM, Kaczmarek LKModulation by CAMP of a slowly activating potassium channel expressed in Xenopus oocytes. J A/ewosc/ 1992,12:290-296,
21. Levin G, Keren T, Peretz T, Chikvashvili D, Thornhill WB: Regulation of RCK1 currents with a cAMP analog via enhanced protein synthesis and direct channel phosphorylation. J Biol Chem 1995, 270:14611-14618. An examination of the role of channel phosphorylation in the response of oocytes expressing Kvl.1 to prolonged treatment (10-16h) with a cyclic AMP analog. This work contrasts with most other studies, which have examined only acute effects of cyclic AMP.
22. + channel inactivation gating by the cAMP-dependent protein kinase. Neuron 1994, 12:1097-1109. A study of the aclion of alkaline phosphalase on N-type inactivation in normal and mutant Shaker channels.
23. Kupper J, Bowlby MR, Marom S, Levitan IBIntracellular and extracellular amlno acids that influence C-type inactivation and its modulation in a voltage-dependent potassium channel. Pflugers Arch 1995, 430:1 -11. The rate of C-type inactivation of the Kv1.3 channel was found to be markedly stowed by simultaneous mutation of three putative phosphorylation sites.
24. + channels expressed In Xenopus oocytes. Biochemistry 1994, 33:8786-8792.
25. Azhderian EM, Hefner D, Lin C-H, Kaczmarek LK, Forscher P: Cyclic AMP modulates fast axonal transport In Aplysia bag call neurons by Increasing the probability of single organelle movement Neuron 1994,12:1223-1233.
26. + current In rabbit vascular smooth muscle cells. Am J Physiol 1995, 26B:H926-H934.
27. Huang X-Y, Morielli AD, Peralta EGMolecular basis of cardiac potassium channel stimulation by protein kinase A. Proc Natl Acad Sci USA 1994, 91:824-62B. A demonstration that the amplitude of current carried by Kv1.2 channel is enhanced by PKA, an effect that required a PKA site on the amino terminus.
28. Wilson GG, O'Neill CA, Sivaprasadarao A, Findlay JBC, Wray DModulation by protein kinase A of a cloned rat brain potassium channel expressed in Xenopus oocytes. Pflugers Arch 1994, 428:186-193
29. Swope SL, Ou 2, Huganir RLPhosphorylation of the nlcotlnlc acetylcholine receptor by protein tyroslne klnases. Ann NY Acad Sci 1995, 757:197-214.
30. Wilson GF, Kaczmarek LKMode-switching of a voltage-gated cation channel is mediated by a protein kinase A-regulated tyroslne phosphatase. Nature 1993, 366:433-430
31. Garber SS, Hoshi T, Aldrich RWRégulation of ionic currents in pheochromocytoma cells by nerve growth factor and dexamethasone. J Neurosci 1969, 9:3976-3987.
32. + channels in PC12 cells. J Cell Biol 1993, 123:1835-1843.
33. Timpe LC, Fantl WJModulation of a voltage-activated potassium channel by peptide growth factor receptors. J Neurosel 1994, 14:1195-1201.
34. Huang X-Y, Morielli AD, Peralta EGTyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled ml muscarinic acetylcholine receptor. Cell 1993, 75:1145-1156.
35. Holmes TC, Fadool DA, Levitan IBTyroslne phosphorylation of the Kv1.3 potassium channel. J Neumsci 1996, 16:1581-1590. A direct demonstration that there is continual phosphorylalion and desphosphorylation of lyrosine residues of the Kvl.3 delayed rectifier potassium channel, and that the state of phosphorylation influences the amplitude of the potassium current
36. 2+- induced regulation of ion channel and MAP kinase functions. Nature 1995, 376:737-745. The authors identify a novel protein tyrosine kinase that directly phosphorylales the Kv1.2 channel. This is the first identification of a tyrosine kinase that directly phosphorylates a potassium channel.
37. + channels are regulated Independently protein kineses and ATP hydrolysis. Neuron 1994, 3:1413-1420 The authors show that rundown of the Kir2.1 channel in excised patches can be prevented by ATP. PKA also enhances current amplitude in channels that have been pre-lreated with ATP. An activator of PKC caused a decrease in current.
38. a4 epithelial cell line by calcium, nucleotJdes and kinases. J Membr Biol 1994, 142:255-266. Inwardly rectifying potassium currents in a cell line were found to be enhanced by ATP and by PKA, which could prevent rundown of channel activity. Application of PKC to membrane patches inhibited single channel activity.
39. Takano K, Stanfield PR, Nakajima S, Nakajima YProtein kinase C-mediated inhibition of an inward rectifier potassium channel by substance P in nucleus basalis neurons. Neuron 1995, 14:999-1008. The authors provide a clear example of modulation of a G-protein-regulated inward rectifier channel by a neuropeptide. The effects of substance P were mimicked by PKC and were rendered irreversible by the phosphatase inhibitor, okadaic acid.
40. FAK a non-receptor tyrosine kinase. The authors suggest that activation of inward rectifier channels is required for activation of the kinase.
41. +channel activity involves phosphorylatlon processe. Proc Natl Acad Sci USA 1994, 91:8077-8081. The inward rectifier channel ROMK1 was expressed in Xenopus oocytes. Rundown of channel activity was observed in cell-free patches but was prevented by the phosphatase inhibitor vanadate, but not by okadaic acid, suggesting thai the channel is regulated by the serine/threonine phosphalase PP2C or by a tyrosine phosphatase. Channel activity was also found to be enhanced by PKA and inhibited by an inhibitor of PKA.
42. Prevarskaya NB, Skryma RM, Vacher P, Daniel N, Djiane J, Duly BRole of tyrosine phosphorylatlon In potassium channel activation. J Biol Chem 1995, 270:24292-24299. An endogenous calcium-activated potassium conductance in CHO cells was shown to be increased by activation ol a transfected prolactin receptor. This effect was blocked by tyrosine kinaso inhibitors and also by an anti-peptide antibody directed against the JAK2 tyrosine fcinase.
43. Griffith LC, Wang J, Zhong Y, Wu C-F, Greenspan RJ; Calclum/calmodulln-dependent protein klnase II and potassium channel subuntt Eag similarly affect plasticity in Drosophito. Proc NatlAcad So' USA 1994, 91:10044-10048.
44. Reinhart PH, Levitan IBKlnase and phosphatase activities intimately associated with a reconstituted calcium-dependent potassium channel. 1 Nevrosci 1995, 15:4572-4578. Calcium-activated potassium channels from rat brain were incorporated into lipid bilayers. The open probability of one class ol these channels was shown to be increased by addition of ATP. The effects of ATP could be mimicked by exogenous PKC or blocked by a PKC inhibitor. A phosphatase inhibitor potentiated the actions of ATP The résulta indicate that these channels are very tightly associated with an endogenous protein kinase and a phosphatase.
45. + channels by Interaction with a family of membrane-associated guanylate kinases. Nature 1995, 378:85-88. The clustering and localization of channels may be important for bringing them into proximity with kinases and phosphatases. In this study, clustering of potassium channels was shown to be induced by a class of proteins that includes the postsynaptic density protein PSD 95.