Cytogenetics and molecular genetics of acute lymphoblastic leukemia

Reviews in Clinical and Experimental Hematology

Volumn 6, Issue 2, 2002, Pages 91-113

  Harrison, Christine J ^a   Foroni, Letizia ^b  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN P16INK4A; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; CANCER RECURRENCE; CHROMOSOME 9; CHROMOSOME TRANSLOCATION; CORRELATION ANALYSIS; CYTOGENETICS; DIPLOIDY; DISEASE ASSOCIATION; GENE; GENE REARRANGEMENT; HAPLOIDY; HUMAN; KARYOTYPE; LEUKEMIA CELL; LEUKEMOGENESIS; MINIMAL RESIDUAL DISEASE; MLL GENE; MOLECULAR GENETICS; OUTCOMES RESEARCH; PROGNOSIS; REVIEW; RISK FACTOR; TUMOR SUPPRESSOR GENE; ACUTE LYMPHOCYTIC LEUKEMIA; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CLASSIFICATION; GENETICS; METHODOLOGY; PLOIDY; T LYMPHOCYTE RECEPTOR GENE;

CHROMOSOME ABERRATIONS; CYTOGENETIC ANALYSIS; GENE REARRANGEMENT; GENES, T-CELL RECEPTOR; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; PLOIDIES;

EID: 0036344108     PISSN: 11270020     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-0734.2002.00069.x     Document Type: Review

References (156)

1. Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis
2. IWCL3. Third International Workshop on Chromosomes in Leukemia (1980): Chromosome abnormalities and their clinical significance in acute lymphoblastic leukemia
3. The Leukaemia Research Fund/United Kingdom Cancer Cytogenetics Group Karyotype Database in acute lymphoblastic leukaemia: A valuable resource for patient management
4. Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood
5. Minimal residual disease tests provide an independent predictor of clinical outcome in adult acute lymphoblastic leukemia
6. Minimal Residual Disease (MRD) tests provide an independent predictor of clinical outcome in adult acute lymphoblastic leukemia
7. Probes for hidden hyperdiploidy in acute lymphoblastic leukaemia
8. Chromosomes and other prognostic factors in acute lymphoblastic leukaemia: A long-term follow-up
9. Ploidy of lymphoblasts is the strongest predictor of treatment outcome in B-progenitor cell acute lymphoblastic leukemia of childhood: A Pediatric Oncology Group study
10. Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia
11. Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA
12. Cytogenetic abnormalities in adult acute lymphoblastic leukemia: Correlations with hematologic findings outcome. A Collaborative Study of the Group Francais de Cytogenetique Hematologique
13. Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA
14. Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure: A Pediatric Oncology Group study
15. Favorable prognosis associated with hyperdiploidy in children with acute lymphocytic leukemia correlates with extra chromosome 6
16. Prognostic impact of trisomies of chromosomes 10, 17, and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (> 50 chromosomes)
17. Isochromosome 17q in childhood acute lymphoblastic leukemia: An adverse cytogenetic feature in association with hyperdiploidy?
18. Detection of numerical chromosomal abnormalities in neoplastic hematopoietic cells by in situ hybridization with a chromosome-specific probe
19. Hypodiploidy with less than 45 chromosomes confers adverse risk in childhood acute lymphoblastic leukaemia: A report from the Children's Cancer Group
20. Prospective karyotype analysis in adult acute lymphoblastic leukemia: The cancer and leukemia Group B experience
21. Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia
22. Near haploid acute lymphoblastic leukemia: Seven new cases and a review of the literature
23. Near haploid childhood acute lymphoblastic leukemia masked by hyperdiploid line: Detection by fluorescence in situ hybridization
24. t(12;21): A new recurrent translocation in acute lymphoblastic leukemia
25. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion
26. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
27. The value of interphase fluorescence in situ hybridization for the detection of translocation t(12;21) in childhood acute lymphoblastic leukemia
28. High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia
29. Abnormalities of the ETV6 gene in the majority of patients with aberrations of the short arm of chromosome 12: A combined PCR and Southern blotting analysis
30. TEL-AML1 fusion in acute lymphoblastic leukaemia of adults
31. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis
32. TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia
33. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials
34. Cytogenetic and FISH studies of a single center consecutive series of 152 childhood acute lymphoblastic leukemias
35. TEL/AML1 fusion gene is a rare event in adult acute lymphoblastic leukemia
36. Low frequency of TEL/AML1 in adult acute lymphoblastic leukemia
37. ETV6/AML1 fusion by FISH in adult acute lymphoblastic leukemia
38. TEL-AML1 fusion transcript in relapsed childhood acute lymphoblastic leukemia
39. Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse
40. Loss of heterozygosity in the chromosomal region 12p12-13 is very common in childhood acute lymphoblastic leukemia and permits the precise localization of a tumor-suppressor gene distinct from p27KIP1
41. Molecular genetics, natural history and the demise of childhood leukaemia
42. The 12; 21 translocation involving TEL and deletion of the other TEL allele: Two frequently associated alterations found in childhood acute lymphoblastic leukemia
43. Cytogenetic abnormalities associated with the t(12;21): A collaborative study of 169 children with t(12;21)-positive acute lymphoblastic leukemia
44. ETV6 is the target of chromosome 12p deletions in t(12;21) childhood acute lymphocytic leukemia
45. Deletion of the short arm of chromosome 12 is a secondary event in acute lymphoblastic leukemia with t(12;21)
46. Cytogenetic pointers to the t(12;21) translocation
47. Chromosome 21 abnormalities with AML1 amplification in acute lymphoblastic leukemia
48. Fluorescence in situ hybridization study of TEL/AML1 fusion and other abnormalities involving TEL and AML1 genes. Correlation with cytogenetic findings and prognostic value in children with acute lymphocytic leukemia
49. TEL-AML1 fusion RNA as a new target to detect minimal residual disease in pediatric B-cell precursor acute lymphoblastic leukemia
50. TEL/AML1 positivity in childhood ALL: Average or better prognosis?
51. Analysis of ETV6/AML1 abnormalities in ALL: Incidence, alternative spliced forms and minimal residual disease value
52. Minimal residual disease studies are beneficial in the follow-up of TEL/AML1 patients with B-precursor acute lymphoblastic leukaemia
53. + T-cell clone reacting to TEL/AML1 fusion protein
54. TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia
55. t(7;12)(q26;p13), a new recurrent translocation involving ETV6 in infant leukaemia
56. t(7;12)(q36;p13) and t(7;12)(q32;p13) translocations involving ETV6 in children 18 months of age or younger with myeloid disorders
57. Chromosomal loss and deletion are the most common mechanisms for loss of heterozygosity from chromosome 5 and 7 in malignant myeloid disorders
58. Fusion of the homeobox gene HLXB9 and the ETV6 gene in infant acute myeloid leukemias with the t(7;12)(q36;p13)
59. The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case
60. Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia
61. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
62. AML1 gene amplification: A novel finding in childhood acute lymphoblastic leukemia
63. Amplification of AML1 in childhood acute lymphoblastic leukemias
64. Extremely poor prognosis of pediatric acute lymphoblastic leukemia with translocation (9;22): Updated experience
65. 1-positive ALL
66. The BCR/ABL hybrid gene
67. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
68. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells
69. Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia
70. Detection of BCR-ABL fusion genes in adult acute lymphoblastic leukemia by the polymerase chain reaction
71. Detection of the BCR-ABL gene by reverse transcription/polymerase chain reaction and fluorescence in situ hybridization in a patient with Philadelphia chromosome negative acute lymphoblastic leukaemia
72. Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization
73. Prospective BCR-ABL analysis by polymerase chain reaction (RT-PCR) in adult acute B-lineage lymphoblastic leukemia: Reliability of RT-nested-PCR and comparison to cytogenetic data
74. Improved sensitivity of BCR-ABL detection: A triple-probe three-color fluorescence in situ hybridization system
75. The impact of the new FISH technologies on the cytogenetics of haematological malignancies
76. Deletions of the derivative chromosome 9 are rare in Philadelphia-positive acute lymphobalstic leukemia
77. Detection of bcr-abl transcripts in Philadelphia chromosome-positive acute lymphoblastic leukemia after marrow transplantation
78. Good correlation between RT-PCR analysis and relapse in Philadelphia (Ph1)-positive acute lymphoblastic leukemia (ALL)
79. Marrow transplants from unrelated donors for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia
80. Involvement of a homolog of drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
81. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
82. General Report on the European Union Concerted Action Workshop on 11q23
83. Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations
84. Ten novel 11q23 chromosomal partner sites
85. The critical role of chromosome translocations in human leukemias
86. Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: Impact of the 11q23 breakpoint on outcome: A report of the Childrens Cancer Group
87. Hematologic malignancies with t(4;11) (q21;q23) - A cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases
88. In utero rearrangements in the trithorax-related oncogene in infant leukaemias
89. Prenatal origin of acute lymphoblastic leukaemia in children
90. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemia with 11q23 chromosomeal translocations
91. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: Investigation of minimal residual disease in acute leukemia
92. Multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 29 translocations and chromosomal aberrations in acute leukemia
93. ALL-1 partial duplication in acute leukemia
94. Incidence and characterisation of MLL gene (11q23) rearrangements in acute myeloid leukemia M1 and M5
95. Partial tandem duplication of ALL1 as a recurrent molecular defect in acute myeloid leukemia with trisomy 11
96. MLL amplification in acute leukaemia: A United Kingdom Cancer Cytogenetics Study Group (UKCCG) study
97. Sensitivity of FISH in detection of MLL gene rearrangements
98. A DNA probe combination for improved detection of MLL/11q23 breakpoints by double-color interphase-FISH in acute leukemias
99. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
100. Detection of ALL-1/AF4 fusion transcript by reverse transcription-polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4; 11) translocation
101. Clinical relevance of residual disease monitoring by polymerase chain reaction in patients with ALL-1/AF-4 positive-acute lymphoblastic leukaemia
102. A prospective study of residual-disease monitoring of the ALL1/AF4 transcript in patients with t(4; 11) acute lymphoblastic leukemia
103. Clinical significance of deletions of chromosome arm 6q in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group
104. Cytogenetic aberrations in adult acute lymphocytic leukemia: Optimal technique may influence the results
105. Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21
106. Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia
107. Detailed physical mapping of chromosome 6 cytogenetic abnormalities in 26 cases of ALL reveals a 2MB common region of deletion and the existence of cryptic balanced translocations
108. 6q deletions in acute lymphoblastic leukemia and non-Hodgkin's lymphomas
109. Detailed deletion mapping of the long arm of chromosome 6 in adult T-cell leukemia
110. Frequent loss of heterozygosity on the long arm of chromosome 6: Identification of two distinct regions of deletion in childhood acute lymphoblastic leukemia
111. Association of chromosome arm 9p abnormalities with abverse risk in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group
112. Incidence and clinical significance of CDKN2/MTS1/P16ink4A and MTS2/P15ink4B gene deletions in childhood acute lymphoblastic leukemia
113. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, 16, 18 and p19 in human leukemia-lymphoma cells
114. Genetic studies of childhood acute lymphoblastic leukemia with emphasis on p16, MLL, and ETV6 gene abnormalities: Results of St Jude Total Therapy Study XII
115. Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia
116. Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia
117. Homozygous deletion of the p16/MTS1 gene in pediatric acute lymphoblastic leukemia is associated with unfavorable clinical outcome
118. Dicentric (9;12) in acute lymphocytic leukaemia and other haematological malignancies: Report from a dic(9;12) study group
119. Monosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukemia
120. Pre-B cell leukemia associated with chromosome translocation 1;19
121. Chromosomal abnormalities in childhood acute lymphoblastic leukemia
122. The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias
123. Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: Clinical features and molecular pathogenesis
124. The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis
125. The detection of E2A rearrangement or E2A-PBX1 fusion transcript in t(1;19) leukaemia
126. Prognostic significance of the balanced t(1;19) and unbalanced der(19)t(1;19) translocations in acute lymphoblastic leukemia
127. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia
128. Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17; 19) acute lymphoblastic leukemia
129. Detection of E2A translocations in leukemias via fluorescence in situ hybridization
130. Expression of the E2A-PBX1 fusion transcripts in t(1;19)(q23;p13) and der(19)(1;19) at diagnosis and in remission of acute lymphoblastic leukemia with different B lineage immunophenotypes
131. E2A-PBX1 chimeric transcript status at end of consolidation is not predictive of treatment outcome in childhood acute lymphoblastic leukemias with a t(1;19)(q23;p13): A Pediatric Oncology Group study
132. Reverse transcriptase/polymerase chain reaction follow-up and minimal residual disease detection in t(1;19)-positive acute lymphoblastic leukemia
133. Translocation t(8;14) in acute lymphoblastic leukaemia, Burkitt type (author's transl)
134. Chromosomal translocations in human cancer
135. Mapping chromosomal breakpoints of Burkitt's t(8;14) translocations far upstream of c-myc
136. Break-points of Burkitt's lymphoma t(8;22) translocations map within a distance of 300kb downstream of MYC
137. Improved outcome in adult B-cell acute lymphoblastic leukemia
138. Biology and treatment of childhood T-lineage acute lymphoblastic leukemia
139. The cytogenetics of acute lymphoblastic leukemia
140. Cytogenetics of childhood T-cell leukemia
141. V(D)J-mediated translocations in lymphoid neoplasms: A functional assessment of genomic instability by cryptic sites
142. A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)
143. A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia
144. The SCL gene: From case report to critical hematopoietic regulator
145. Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes
146. Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: A Pediatric Oncology Group study
147. Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study
148. TAL1, TAL2 and LTL1: A family of basic helix-loop-helix proteins implicated in T cell acute leukaemia
149. Quantification of minimal residual disease in T-lineage acute lymphoblastic leukemia with the TAL-1 deletion using a standardized real-time PCR assay
150. Application of long-distance polymerase chain reaction to detection of junctional sequences created by chromosomal translocation in mature B-cell neoplasms
151. Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping
152. Multiplex fluorescence in situ hybridisation and cross species color banding of a case of chronic myeloid leukemia in blastic crisis with a complex philadelphia translocation
153. Sequential FISH reveals an abnormal karyotype involving 14 chromosomes in a child with acute lymphoblastic leukemia
154. Detection and quantification of residual disease in chronic myelogenous leukemia