Deletion of the short arm of chromosome 12 is a secondary event in acute lymphoblastic leukemia with t(12;21)

Leukemia

Volumn 10, Issue 1, 1996, Pages 167-170

  Romana, S P ^a   Le Coniat, M ^a   Poirel, H ^a   Marynen, P ^b   Bernard, O A ^a   Berger, R ^a  

^a INSERM   (France)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Acute lymphoblastic leukemia; FISH; t(12; 21); TEL

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CASE REPORT; CHROMOSOME 12P; CHROMOSOME DELETION; CHROMOSOME R BAND; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 21; COSMID; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; METAPHASE; PRIORITY JOURNAL; RELAPSE; SOUTHERN BLOTTING; TUMOR SUPPRESSOR GENE; YEAST ARTIFICIAL CHROMOSOME;

EID: 0030070736     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Romana SP, Le Coniat M, Berger R. t(12;21): a new recurrent translocation in acute lymphoblastic leukemia. Genes Chromosom Cancer 1994; 9: 186-191.
2. Golub TR et al. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1995; 92: 4917-4921.
3. Romana SP et al. The t(12;21) of acute lymphoblastic leukemia results in a TEL-AML1 gene fusion. Blood 1995; 12: 3662-3670.
4. Raeymaekers P et al. A radiation hybrid map with 60 loci covering the entire short arm of chromosome 12. Genomics 1995; 29. 170-178.
5. Stegmaier K et al. Frequent loss of heterozygosity at the TEL gene locus in acute lymphoblastic leukemia of childhood. Blood 1995; 86: 38-44.
6. Romana SP et al. High frequency of t(12;21) in childhood B lineage acute leukemia. Blood (in press).
7. Kobayashi H et al. Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases. Blood 1994; 84: 3473-3482.
8. Sato Y et al. TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies. Blood 1995; 86: 1525-1533.