The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case

Cancer Research

Volumn 61, Issue 12, 2001, Pages 4666-4670

  Cazzaniga, Giovanni ^a   Daniotti, Maria ^a   Tosi, Sabrina ^b   Giudici, Giovanni ^a   Aloisi, Alessandra ^a   Pogliani, Enrico ^a   Kearney, Lyndal ^b   Biondi, Andrea ^a  

^a SAN GERARDO HOSPITAL   (Italy)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; B LYMPHOCYTE; BINDING SITE; CASE REPORT; CHIMERA; CHROMOSOME 9P; CHROMOSOME TRANSLOCATION 9; GENE FUSION; GENE MAPPING; GENE REARRANGEMENT; HUMAN; ONCOGENE; PRIORITY JOURNAL;

B-CELL-SPECIFIC ACTIVATOR PROTEIN; BASE SEQUENCE; BLOTTING, NORTHERN; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 9; DNA-BINDING PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, ACUTE; MOLECULAR SEQUENCE DATA; PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0035875036     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
2. Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of function experiments
3. Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9
4. The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma
5. Identification of new partner chromosomes involved in fusions with the TEL (TEL) gene in hematologic malignancies
6. Fusion of PDGF receptor β to a novel Ets-like gene, Tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
7. The role of chromosome translocations in leukemogenesis
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9. The role of TEL fusion genes in pediatric leukemias
10. Translocation (12;22)(p 13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MNI gene on 22q11
11. Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(qII-q12;p13)
12. The MNI-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity
13. Genomic organization of TEL: The human ETS-variant gene 6
14. The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene
15. Chromosomal translocations in human cancer
16. The role of chimeric paired box transcription factors in the pathogenesis of pediatric rhabdomyosarcoma
17. Pax genes and their role in organogenesis
18. PAX8-PPARy1 fusion oncogene in human thyroid carcinoma
19. TEL is a sequence-specific transcriptional repressor
20. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
21. Deregulation of PAX-5 by translocation of the Em enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma
22. The incidence of chromosome 9921 abnormalities and deletions of tumor, suppressor genes p15(INK4b)/p16(INK4a)/p14(ARF) in patients with acute lymphoblastic leukemia