Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian Multicenter Therapy Trials

Blood

Volumn 90, Issue 2, 1997, Pages 571-577

  Borkhardt, Arndt ^b   Cazzaniga, Giovanni ^b   Viehmann, Susanne ^b   Valsecchi, Maria Grazia ^b   Ludwig, Wolf Dieter ^b   Burci, Linda ^b   Mangioni, Silvia ^b   Schrappe, Martin ^b   Riehm, Hansjörg ^b   Lampert, Fritz ^b   Basso, Giuseppe ^b   Masera, Giuseppe ^b   Harbott, Jochen ^b   Biondi, Andrea ^a  

^a SAN GERARDO HOSPITAL   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CHILD; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 21; CHROMOSOME TRANSLOCATION 9; CYTOGENETICS; DNA CONTENT; FEMALE; GENE FUSION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0030742017     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.2.571.571_571_577     Document Type: Article

References (32)

1. Pui CH: Childhood leukemias. N Engl J Med 332:1618, 1995
2. Pui CH, Crist W: Biology and treatment of acute lymphoblastic leukemia. J Pediatr 124:491, 1994
3. Pui CH, Behm FG, Crist WM: Clinical and biologic relevance of immunologic marker study in childhood acute lymphoblastic leukemia. Blood 82:343, 1993
4. Ribeiro RC, Pui CH: Prognostic factors in childhood acute lymphoblastic leukemia. Hematol Pathol 7:121, 1993
5. Raimondi SC: Current status of cytogenetic research in childhood acute lymphoblastic leukemia. Blood 81:2237, 1993
6. Trueworthy R, Shuster J, Look T, Crist W, Borowitz M, Carroll A, Frankel L, Harris M, Wagner H, Haggard M, Mosijczuk A, Pullen J, Steuber P, Land V: Ploidy of lymphoblasts is the strongest predictor of treatment outcome in B-progenitor cell acute lymphoblastic leukemia of childhood: A Pediatric Oncology Group. J Clin Oncol 10:606, 1992
7. Romana SP, Le Coniat M, Berger R: t(12;21): A new recurrent translocation in acute lymphoblastic leukemia. Genes Chromosom Cancer 9:186, 1994
8. Kobayashi H, Rowley JD: Identification of cytogenetically undetected 12p13 translocations and associated deletions with fluorescence in situ hybridization. Genes Chromosom Cancer 12:66, 1995
9. Golub TR, Barker GF, Lovett M, Gilliland DG: Fusion of the PDGF receptor β to a novel ets-like gene, tel, in chronic myleomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307, 1994
10. Nucifora G, Rowley JD: AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 86:1, 1995
11. Romana SP, Mauchauffe M, Le Coniat M, Chumakov I, Le Paslier D, Berger R, Bernard OA: The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85:3662, 1995
12. Romana SP, Poirel H, Leconiat M, Flexor MA, Mauchauffe M, Jonveaux P, Macintyre EA, Berger R, Bernard OA: High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood 86:4263, 1995
13. Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML, Chan GC, Pui CH, Grosveld G, Downing JR: TEL/ AML1 fusion resulting from cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 9:1985, 1996
14. Cayuela JM, Baruchel A, Orange C, Madani A, Auclerc MF, Daniel MT, Schaison G, Sigaux F: TEL-AML1 fusion RNA as a new target to detect minimal residual disease in pediatric B-cell precursor acute lymphoblastic leukemia. Blood 88:302, 1996
15. Biondi A, Rambaldi A, Rossi V, Elia L, Caslini C, Basso G, Battista R, Barbui T, Mandelli F, Masera G, Croce C, Canaani E, Cimino G: Detection of ALL-1/AF4 fusion transcript by reverse transcription-polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4;11) translocation. Blood 82:2943, 1993
16. Schlieben S, Borkhardt A, Reinisch I, Ritterbach J, Janssen JWG, Ratei R, Schrappe M, Repp R, Zimmermann M, Kabisch H, Janka-Schaub G, Bartram CR, Ludwig WD, Riehm H, Lampert F, Harbott J: Incidence and clinical outcome of children with BCR/ ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92. Leukemia 10:957, 1996
17. van der Does-van den Berg A, Bartram C, Basso G, Benoit YCM, Biondi A, Debatin KM, Haas OA, Harbott J, Kamps WA, Koller U, Lampert F, Kudwig WD, Niemeyer CM, van Wering E: Minimal requirements for the diagnosis, classification and evaluation of the treatment of childhood acute lymphoblastic leukemia (ALL) in the "BFM Family" Cooperative Group. Med Pediatr Oncol 20:497, 1992
18. Schrappe M, Reiter A, Sauter S, Ludwig WD, Wörmann B, Harbott J, Bender-Götze C, Dörffel W, Dopfer R, Frey E, Havers W, Henze G, Kühl J, Richter R, Ritter J, Treuner J, Zintl F, Odenwald E, Weite K, Riehm H: Conception and interim analysis of trial ALL-BFM 90 for the treatment of children and adolescents with acute lymphoblastic leukemia: Significance of therapy response in peripheral blood and bone marrow. Klin Pädiat 206:208, 1994
19. Conter V, Rizzari C, Aricò M, Basso G, Cantù-Rajnoldi, Colella R, Dibenedetto SP, Di Tullio MT, Messina C, Miniero R, Mori PG, Pession A, Rondelli R, Silvestri D, Testi AM, Valsecchi MG, Masera G, for the "Associazione Italiana Ematologia Oncologia Pediatrica" (AIEOP): Preliminary results of the AIEOP '91 study for childhood acute lymphoblastic leukemia (ALL). Med Pediatr Oncol 25:283, 1995 (abstr)
20. Hiddemann W, Schumann J, Andreeff M, Barlogie B, Herman CJ, Leif RC, Mayall BH, Murphy RF, Sandberg AA: Convention on nomenclature for DNA cytometry. Cytometry 5:445, 1984
21. Chomczynski P, Sacchi N: Single-step method of RNA isolation by guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
22. Sambrock J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1989
23. Cox DR: Regression models and life-tables (with discussion). J R Stat Soc B 34:187, 1972
24. Fears S, Vignon C, Bohlander SK, Smith S, Rowley JD, Nucifora G: Correlation between the ETV6/CBFA2 (TEL/AML1) fusion gene and karyotypic abnormalities in children with B-cell precursor acute lymphoblastic leukemia. Genes Chromosom Cancer 17:127, 1996
25. Wlodarska I, Mecucci C, Marynen P, Guo C, Franckx D, La Starza R, Aventin A, Bosly A, Martelli MF, Cassiman JJ, Van den Berghe H: TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13). Blood 85:2848, 1995
26. Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, van Kessel AG, Riegman P, Deprez RI, Zwarthoff E, Hagemeijer A, Grosveld G: Translocation (12;22)(p13;q11) in myeloproliferative disorders results in fusion of the ets-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene 10:1511, 1995
27. Sobol RE, Mick R, Royston I, Davey FR, Ellison RR, Newman R, Cuttner J, Griffin JD, Collins H, Nelson DA, Bloomfield CD: Clinical importance of myeloid antigen expression in adult acute lymphoblastic leukemia. N Engl J Med 316:1111, 1987
28. Wiersma SR, Ortega J, Sobel E, Weinberg KI: Clinical importance of myeloid-antigen expression in acute lymphoblastic leukemia of childhood. N Engl J Med 324:800, 1991
29. Drexler HG, Ludwig W-D: Incidence and clinical relevance of myeloid antigen-positive acute lymphoblastic leukemia, in Ludwig W-D, Thiel E (eds): Recent Advances in Cell Biology of Acute Leukemia. Berlin, Germany, Springer-Verlag, 1993, p 53
30. Nakao M, Yokota S, Horiike S, Taniwaki M, Kashima K, Sonoda Y, Koizumi S, Takaue Y, Matsushita T, Fujimoto T, Misawa S: Detection and quantification of TEL/AML1 fusion transcripts by polymerase chain reaction in childhood acute lymphoblastic leukemia. Leukemia 10:1463, 1996
31. Chambost H, Michel G, Thuret I, Toiron Y, Brunet C, Capodano AM, Perrimond H, Gabert J: TEL/AML1 transcript may not be an independent prognosis factor in childhood acute lymphoblastic leukemia. Blood 88:72a, 1996 (abstr, suppl 1)
32. McLean TW, Ringold S, Neuberg D, Stegmaier K, Tantravahi R, Ritz J, Koeffler HP, Takeuchi S, Janssen WG, Seriu T, Bartram CR, Sallan SE, Gilliland DG, Golub TD: TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia. Blood 88:4252, 1996