The effector phase of physiological cell death relies exclusively on the posttranslational activation of resident components

Experimental Cell Research

Volumn 277, Issue 1, 2002, Pages 15-30

  Chang, Sandra H ^a   Cvetanovic, Marija ^a   Harvey, Kevin J ^a   Komoriya, Akira ^b   Packard, Beverly Z ^b   Ucker, David S ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b OncoImmunin Inc   (United States)

Author keywords

Apoptosis; Caspases; Cdk2; Cyclin A; Macromolecular synthesis; Physiological cell death; Post translational modification; Programmed cell death

Indexed keywords

CASPASE 9; CYCLOHEXIMIDE; CYTOCHROME C; DACTINOMYCIN; DEXAMETHASONE; PROTEIN BCL 2;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; HELA CELL; HUMAN; HUMAN CELL; MACROMOLECULE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING;

EID: 0036344061     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5539     Document Type: Article

References (74)

1. Inhibitory effect of actinomycin D on tail atrophy in Xenopus larvae at metamorphosis
2. Requirement for RNA and protein synthesis for induced regression of the tadpole tail in organ culture
3. Programmed cell death: Activation of lysis by a mechanism involving the synthesis of protein
4. Gene activation is required for developmentally programmed cell death
5. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death
6. IL-2 addiction: Withdrawal of growth factor activates a suicide program in dependent T cells
7. Gene induction by γ-irradiation leads to DNA fragmentation in lymphocytes
8. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
9. Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation
10. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: Protection by protein synthesis inhibition
11. Effect of cycloheximide and mRNA synthesis inhibition on death of trophically deprived ciliary ganglion neurons in culture
12. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
13. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
14. Specific dual effect of cycloheximide on B lymphocyte apoptosis: Involvement of CPP32/caspase-3
15. Expression of two distinct cytolytic mechanisms among murine CD4 subsets
16. Differential effects of protein synthesis inhibition on CTL and targets in cell-mediated cytotoxicity
17. Induction of manganous superoxide dismutase by tumor necrosis factor: Possible protective mechanism
18. Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis
19. Caspase-dependent Cdk activity is a requisite effector of apoptotic death events
20. Commitment and effector phases of the physiological cell death pathway elucidated with respect to Bcl-2, caspase, and cyclin-dependent kinase activities
21. Inhibition of death receptor signals by cellular FLIP
22. Membrane-targeted green fluorescent protein reliably and uniquely marks cells through apoptotic death
23. Molecular mapping of the physiological cell death process: Mitochondrial events may be disordered
24. Profluorescent protease substrates: Intramolecular dimers described by the exciton model
25. Assessment of caspase activities in intact apoptotic thymocytes using cell-permeable fluorogenic caspase substrates
26. Androgen-repressed messages in the rat ventral prostate
27. Cascade induction of c-fos, c-myc, and heat shock 70K transcripts during regression of the rat ventral prostate gland
28. Induction of the TRPM-2 gene in cells undergoing programmed cell death
29. Genes newly identified as regulated by glucocorticoids in murine thymocytes
30. Isolation and characterization of transcripts induced by androgen withdrawal and apoptotic cell death in the rat ventral prostate
31. Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events
32. Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of Cyclin D1 during programmed cell death
33. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77
34. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
35. Differential requirement for caspase 9 in apoptotic pathways in vivo
36. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
37. Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism
38. Phosphorylation of Bcl-2 is a maker of M phase events and not a determinant of apoptosis
39. Transcriptional control of steroid-regulated apoptosis in murine thymoma cells
40. p53 is required for radiation-induced apoptosis in mouse thymocytes
41. Thymocyte apoptosis induced by p53-dependent and independent pathways
42. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
43. p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes
44. waf/cip1
45. RB regulates the stability and the apoptotic function of p53 via MDM2
46. Death by suicide: One way to go in mammalian cellular development?
47. An essential role for NF-κB in preventing TNF-α-induced cell death
48. TNF-and therapy-induced apoptosis: Potentiation by inhibition of NF-κB
49. Suppression of TNF-α-induced apoptosis by NF-κB
50. Expression of caspase and BCL-2 apoptotic family members in mouse preimplantation embryos
51. Dredd, a novel effector of the apoptosis activators Reaper, Grim, and Hid in Drosophila
52. Activation of the reaper gene during ectopic cell killing in Drosophila
53. DRONC, an ecdysone-inducible Drosophila caspase
54. bcl-2 Proto-oncogene expression during human T cell development: Evidence for biphasic regulation
55. + stage during positive selection and promotes thymocyte differentiation at several control points
56. Activation of human monocytes induces differential resistance to apoptosis with rapid down regulation of caspase-8/FLICE
57. Postnatal distribution of cpp32/caspase 3 mRNA in the mouse central nervous system: An in situ hybridization study
58. Expression of bcl-2, bax, and caspase-3 in the brain of the developing rat
59. Expression of genes involved in initiation, regulation, and execution of apoptosis in human neutrophils and during neutrophil differentiation of HL-60 cells
60. Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2α
61. Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells
62. Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2α in apoptosis
63. cpp32 messenger RNA neosynthesis is induced by fatal axotomy and is not regulated by athanatal Bcl-2 over-expression
64. The mouse cpp32 mRNA transcript is early up-regulated in axotomized motoneurons following facial nerve transection
65. Nerve growth factor determines survival and death of PC12 cells by regulation of the bcl-x, bax, and caspase-3 genes
66. Differential changes of bax, caspase-3 and p21 mRNA expression after transient focal brain ischemia in the rat
67. Caspase-3 expression by cerebellar granule neurons is regulated by calcium and cyclic AMP
68. Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlates with apoptotic cell death
69. Constitutive expression of the machinery for programmed cell death
70. Are caspases involved in the death of cells with a transcriptionally inactive nucleus? Sperm and chicken erythrocytes
71. Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells
72. Distinct modes of macrophage recognition for apoptotic and necrotic cells are not specified exclusively by phosphatidylserine exposure
73. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
74. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transitions determine the mode of cell death