spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development

Development

Volumn 129, Issue 4, 2002, Pages 917-933

  Reim, Gerlinde ^a   Brand, Michael ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

Author keywords

Competence; Fgf8; Hindbrain; Isthmus; MHB; Oct3 4; pas2; pou2; Pou5f1; spiel ohne grenzen; Zebrafish

Indexed keywords

ENG2 PROTEIN; ENG3 PROTEIN; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTOR RECEPTOR; FKD3 PROTEIN; GBX2 PROTEIN; GENE PRODUCT; HER5 PROTEIN; KROX20 PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OCTAMER TRANSCRIPTION FACTOR 4; SPRY4 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR POU2; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; BRAIN DEVELOPMENT; BRAIN INJURY; CELL POPULATION; COMPETENCE; CONTROLLED STUDY; ECTODERM; EMBRYO; EMBRYO PATTERN FORMATION; EMBRYONIC STRUCTURES; ENZYME ACTIVITY; GASTRULATION; GENE EXPRESSION; GENE FUNCTION; GENE MAPPING; GENE MUTATION; HOMOZYGOSITY; MAMMAL; MESENCEPHALON; MESODERM; MUTANT; NEUROECTODERM; NONHUMAN; PRIMORDIUM; PRIORITY JOURNAL; PROTEIN SECRETION; REVIEW; RHOMBENCEPHALON; SIGNAL TRANSDUCTION; VERTEBRATE; ZEBRA FISH;

ANIMALS; DNA-BINDING PROTEINS; ENDODERM; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION; MICE; MUTAGENESIS; NEURONS; OCTAMER TRANSCRIPTION FACTOR-3; PROSENCEPHALON; TRANSCRIPTION FACTORS; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO; MAMMALIA; VERTEBRATA;

EID: 0036333254     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (104)

1. A molecular pathway leading to endoderm formation in zebrafish
2. Engrailed defines the position of dorsal di-mesencephalic boundary by repressing diencephalic fate
3. The FGF family of growth factors and oncogenes
4. Keeping and raising zebrafish
5. Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain
6. The caudal limit of Otx2 expression positions the isthmic organizer
7. The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation. of the midbrain, hindbrain and for pre-gastrula morphogenesis
8. Graded interference with FGF signalling reveals its dorsoventral asymmetry at the mid-hindbrain boundary
9. FGF is an essential regulator of the fifth cell division in preimplantation mouse embryos
10. Expression of sprouty2 during early development of the chick embryo is coincident with known sites of FGF signalling
11. Differential display of genes expressed at the midbrain - Hindbrain junction identifies sprouty2: An FGF8-inducible member of a family of intracellular FGF antagonists
12. Mutations affecting the cardiovascular system and other internal organs in the zebrafish
13. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor
14. Midbrain development induced by FGF8 in the chick embryo
15. Molecular mechanisms of liver development and differentiation
16. Identification of separate slow and fast muscle precursor cells in vivo, prior to somite formation
17. A crucial component of the endoderm formation pathway, CASANOVA, is encoded by a novel sox-related gene
18. Coordinate embryonic expression of three zebrafish engrailed genes
19. Repression of ets-2-induced transactivation of the tau interferon promoter by oct-4
20. 1Neu mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye and kidney
21. Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter
22. A zebrafish engrailed-like homeobox sequence expressed during embryogenesis
23. A role for Fgf-8 in the dorsoventral patterning of the zebrafish gastrula
24. Sprouty4 acts in vivo as a feedback-induced antagonist of Fgf signaling in zebrafish
25. Neuroepithelial co-expression of Gbx2 and Otx2 precedes Fgf8 expression in the isthmic organizer
26. Dackel acts in the ectoderm of the zebrafish pectoral fin bud to maintain AER signaling
27. Direct and continuous assessment by cells of their position in a morphogen gradient
28. Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation
29. The expression of a zebrafish gene homologous to Drosophila snail suggests a conserved function in invertebrate and vertebrate gastrulation
30. Pou-2 - a zebrafish gene active during cleavage stages and in the early hindbrain
31. Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon
32. Pairing SOX off: With partners in the regulation of embryonic development
33. Anf: A novel class of vertebrate homeobox genes expressed at the anterior end of the main embryonic axis
34. Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways
35. Expression of wnt10a in the central nervous system of developing zebrafish
36. Induction and patterning of the vertebrate nervous system
37. Casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish
38. Stages of embryonic development of the zebrafish
39. Medaka spalt acts as a target gene of hedgehog signaling
40. Expression of the zebrafish paired box gene pax during early neurogenesis
41. Expression pattern of zebrafish pax genes suggests a role in early brain regionalization
42. A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
43. Development of spinal neurons and tracts in the zebrafish embryo
44. Early anterior/posterior patterning of the midbrain and cerebellum
45. FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate
46. Patterning the vertebrate neuraxis
47. A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary
48. Isolation and characterization of zebrafish gbx genes and their function in development of the midbrain-hindbrain-boundary organizer., in preparation
49. Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain
50. The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain
51. The role of kreisler in segmentation during hindbrain development
52. Patterning of the embryonic avian midbrain after experimental inversions: A polarizing activity from the isthmus
53. Expression of the homeobox Chick-en gene in chick/quail chimeras with inverted mesmetencephalic grafts
54. FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression
55. - mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
56. Differences in left-right axis pathways in mouse and chick: Functions of FGF8 and SHH
57. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
58. Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants
59. A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
60. Valentino: A zebrafish gene required for normal hindbrain segmentation
61. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
62. Fgf8 is required for outgrowth and patterning of the limbs
63. Different spatio-temporal expressions of three otx homeoprotein transcripts during zebrafish embryogenesis
64. Differential expression of two zebrafish emx homeoprotein mRNAs in the developing brain
65. Transcription of a zebrafish gene of the hairy-Enhancer of split family delineates the midbrain anlage in the neural plate
66. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
67. Fork head domain genes in zebrafish
68. Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development
69. Oct-4: Control of totipotency and germline determination
70. Characterization of three novel members of the zebrafish Pax2/5/8 family: Dependency of Pax5 and Pax8 expression on the Pax2.1(noi) function
71. Requirement for zebrafish acerebellar/FGF8 in midbrain polarization, mapping and confinement of the retinotectal projection
72. Analysis of the zebrafish pax2.1 promoter in transgenic lines reveals a positive transcriptional feedback loop in mid-hindbrain boundary development
73. Tight transcriptional control of the ETS domain factors Erm and Pea3 by FGF signaling during early zebrafish nervous system development
74. Fgf8 is mutated in zebrafish acerebellar mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis
75. Overlapping and distinct functions provided by fgf17, a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs
76. Induction and differentiation of the zebrafish heart requires Fibroblast Growth Factor 8 (Fgf8/acerebellar)
77. The midbrain-hindbrain organizer
78. The midbrain-hindbrain boundary genetic cascade is activated ectopically in the diencephalon in response to the widespread expression of one of its components, the medaka gene Ol-eng2
79. Zebrafish pea3 and erm are general targets of FGF8 signaling
80. Pattern formation in the vertebrate neural plate
81. Xenopus embryos regulatie the nuclear localization of XMyoD
82. Mutations affecting the development of the embryonic zebrafish brain
83. Mutations affecting development of the embryonic zebrafish brain
84. A family of octamer-specific proteins present during mouse embryogenesis: Evidence for germline-specific expression of an Oct factor
85. Morpholino-induced knock-down of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique function in midbrain-hindbrain boundary development
86. Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos
87. Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: Evidence from targeted mutations
88. The zebrafish Pax3 and Pax7 homologues are highly conserved, encode multiple isoforms and show dynamic segment-like expression in the developing brain
89. Expression of two zebrafish homologues of the murine Six3 gene demarcates the initial eye primoridia
90. Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon
91. Inductive interactions direct early regionalization of the mouse forebrain
92. fgfr3 and regionalization of anterior neural tube in zebrafish
93. Initiation of neural induction by FGF signalling before gastrulation
94. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
95. A novel POU domain gene, zebrafish pou2: Expression and roles of two alternatively spliced twin products in early development
96. A homeobox gene essential for zebrafish notochord development
97. Wnt4 affects morphogenesis when misexpressed in the zebrafish embryo
98. Cooperation of Pax2 and Pax5 in midbrain and cerebellum development
99. Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function
100. Patterning the zebrafish central nervous system
101. Multiple developmental defects in Engrailed-1 mutant mice: An early mid-hindbrain deletion and patterning defects in forelimbs and sternum
102. Neural plate patterning: Upstream and downstream of the isthmic organizer
103. Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish