Molecular mechanisms of liver development and differentiation

Current Opinion in Cell Biology

Volumn 11, Issue 6, 1999, Pages 678-682

  Darlington, Gretchen J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; NUCLEAR FACTOR I; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL DIFFERENTIATION; CELL TRANSPLANTATION; EMBRYO; EMBRYO DEVELOPMENT; ENHANCER REGION; LIVER CELL CULTURE; LIVER DEVELOPMENT; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TISSUE CULTURE;

ANIMALIA; MAMMALIA;

EID: 0032704858     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(99)00035-6     Document Type: Review

References (32)

1. LeDouarin N. An experimental analysis of liver development. Medical Biol. 53:1975;427-455.
2. Jung J., Zheng M., Goldfarb M., Zaret K.S. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science. 284:1999;1998-2003. This paper demonstrates the activity of and the requirement for fibroblast growth factors in directing the differentiation of the embryonic foregut toward the hepatic lineage. The specificity of the factors and the threshold of activity suggest that this signaling event is tightly regulated.
3. Gualdi R., Bossard P., Zheng M., Hamada Y., Coleman J.R., Zaret K.S. Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control. Genes Dev. 10:1996;1670-1682.
4. •], indicating that multiple factors play a role in early specification.
5. Zaret K. Developmental competence of the gut endoderm: Genetic potentiation by GATA and HNF3/fork head proteins. Dev Biol. 209:1999;1-10.
6. Duncan S.A., Navas M.A., Dufort D., Rossant J., Stoffel M. Regulation of a transcription factor network required for differentiation and metabolism. Science. 281:1998;692-695. This paper describes the use of embryoid bodies derived from embryonic stem cells that lacked either hepatocyte nuclear factor (HNF)3α or β to establish their relative activity, and the role of HNF3β in regulating HNF4 following insulin stimulation.
7. Amicone L., Spagnoli F.M., Spath G., Giodano S., Tommasini C., Bernardini S., De Luca V., Della Rocca C., Weiss M.C., Comoglio P.M., Tripodi M. Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. EMBO J. 16:1997;495-503.
8. Spagnoli F.M., Amicone L., Tripodii M., Weiss M.C. Identification of a bipotential precursor cell in hepatic cell lines derived from transgenic mice expressing cyto-met in the liver. J Cell Biol. 143:1998;1101-1112. The culture of distinct populations of cells derived from the cMet transgenic mice [7] revealed that mulitple cell types (or cells with multiple differentiation potentials) could be obtained from in vitro studies of hepatocyte and bile duct cell differentiation.
9. Welm A.L., Timchenko N.A., Darlington G.J. C/EBP alpha regulates generation of C/EBP beta isoforms through activation of specific proteolytic cleavage. Mol Cell Biol. 19:1999;1695-1704. Identification of a novel mechanism for generation of C/EBPβ isoforms by proteolytic cleavage was demonstrated. Because the cell has at least two methods of producing truncated C/EBPβ proteins (alternative translation and proteolytic cleavage) it is interesting to speculate that multiple biological processes may be dependent on the various C/EBPβ proteins.
10. Petersen B.E., Bowen W.C., Patrene K.D., Mars W.M., Sullivan A.K., Murase N., Boggs S.S., Greenberger J.S., Goff J.P. Bone marrow as a potential source of hepatic oval cells. Science. 284:1999;1168-1170. The pluripotent nature of the bone marrow derived cells was clearly demonstrated in this paper. The possibility that these cells represent true stem cells is an exciting one.
11. Zaret K.S. Molecular genetics of early liver development. Annu Rev Physiol. 58:1996;231-251.
12. Zaret K. Early liver differentation: genetic potentiation and multilevel growth control. Curr Opin Genet Dev. 8:1998;526-531.
13. Ang S.L., Rossant J. HNF-3β is essential for node and notochord formation in mouse development. Cell. 78:1994;561-574.
14. Weinstein D.C., Ruiz I., Altaba A., Chen W.S., Hoodless P., Prezioso V.R., Jessell T.M., Darnell J.E. Jr. The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell. 78:1994;575-588.
15. Kuo C.T., Morrisey E.E., Anandappa R., Sigrist K., Lu M.M., Parmacek M.S., Soudais C., Leiden J.M. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11:1997;1048-1060.
16. Molkentin J.D., Lin Q., Duncan S.A., Olson E.N. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11:1997;1061-1072.
17. Cereghini S. Liver-enriched transcription factors and hepatocyte differentiation. FASEB J. 10:1996;267-282.
18. Chen W.S., Manova K., Weinstein D.C., Duncan S.A., Plump A.S., Prezioso V.R., Bachvarova R.F., Darnell J.E. Jr. Disruption of the HNF-4 gene expressed in visceral endoderm leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev, 8:1994;2466-2477.
19. (-/-) embryos. Development. 124:1997;279-287.
20. Hennighausen L., Wall R.J., Tillmann U., Li M., Furth P.A. Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV-LTR and the tetracycline responsive system. J Cell Biochem. 59:1995;463-472.
21. Spath G.E., Weiss M.C. Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells. Mol Cell Biol. 17:1997;1913-9999.
22. Kuo C.J., Conley P.B., Chen L., Sladek F.M., Darnell J.E. Jr., Crabtree G.R. A transcriptional hierarchy involved in mammalian cell-type specification. Nature. 355:1992;457-461.
23. Bulla G.A., Fournier R.E.K. Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants. Mol Cell Biol. 14:1994;7086-7094.
24. Ben Ze'ev A., Robinson G.S., Bucher N.L.R., Farmer S.R. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc Natl Acad Sci USA. 85:1998;2161-2165.
25. Greenbaum L.E., Li W., Cressman D.E., Peng Y., Ciliberto G., Poli V., Taub R. CCAAT enhancer-binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. J Clin Invest. 102:1999;996-1007.
26. Croniger C., Trus M., Lysek-Stupp K., Cohen H., Liu Y., Darlington G.J., Poli V., Hanson R.W., Reshef L. Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth. J Biol Chem. 272:1997;26306-26312.
27. Croniger C., Leahy P., Reshef L., Hanson R.W. C/EBP and the control of phosphoenolpyruvate carboxykinase gene transcription in the liver. J Biol Chem. 273:1998;31629-31632.
28. Descombes P., Schibler U. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell. 67:1991;569-579.
29. Ossipow V., Descombes P., Schibler U. CCAAT/enhancer binding protein mRNA is translated into multiple protein isoforms with different transcription activation potentials. Proc Natl Acad Sci USA. 90:1993;8219-8223.
30. Talbot D., Descombes P., Schibler U. The 5′ flanking region of the rat LAP (C/EBP beta) gene can direct high-level, position-independent, copy number-dependent expression in multiple tissues in transgenic mice. Nucleic Acids Res. 22:1994;756-766.
31. Fausto N. Liver stem cells. The Liver Biology and Pathobiology, edn 3. 1994;1501-1518 Raven Press Ltd, New York.
32. Burgess-Beusse B., Soriano H.B., Darlington G.J. Gene knockout animal models. Strain A., Diehl A.M. Liver Growth and Regeneration. 1998;143-156 Chapman and Hall, London.