Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function

Development

Volumn 124, Issue 15, 1997, Pages 2923-2934

  Wassarman, Karen Montzka ^a,e   Lewandoski, Mark ^a   Campbell, Kenneth ^b,f   Joyner, Alexandra L ^b   Rubenstein, John L R ^a   Martinez, Salvador ^c,d   Martin, Gail R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MURCIA   (Spain)

^d UNIVERSITY OF ALICANTE   (Spain)

^e EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^f LUND UNIVERSITY   (Sweden)

Author keywords

Anterior hindbrain; Cerebellum; Gbx2; Mes met junction; Mid hindbrain organizer; Midbrain; Mouse; Rhombomeres

Indexed keywords

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO PATTERN FORMATION; GENE EXPRESSION; GENE FUNCTION; HOMEOBOX; MESENCEPHALON; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHOMBENCEPHALON;

ANIMALS; BODY PATTERNING; CEREBELLUM; EPHRIN-A2; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTORS; GASTRULA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GROWTH SUBSTANCES; HOMEODOMAIN PROTEINS; HOMOZYGOTE; MESENCEPHALON; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; OTX TRANSCRIPTION FACTORS; PROTO-ONCOGENE PROTEINS; RHOMBENCEPHALON; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; WNT PROTEINS; WNT1 PROTEIN; ZEBRAFISH PROTEINS;

ANIMALIA;

EID: 0030851192     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Abbott, L. and Jacobowitz, D. (1995). Development of calretinin-immunoreactive unipolar brush-like cells and an afferent pathway to the embryonic and early postnatal mouse cerebellum. Anat. Embryol. 191, 541-559.
2. Acampora, D., Mazan, S., Lallemand, Y., Avantaggiato, V., Maury, M., Simeone, A. and Brulet, P. (1995). Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121, 3279-3290.
3. Ang, S., Conlon, R., Jin, O. and Rossant, J. (1994). Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm expiants. Development 120, 2979-2989.
4. Bally-Cuif, L., Cholley, B. and Wassef, M. (1995). Involvement of Wnt-1 in the formation of the mes/metencephalic boundary. Mech. Dev. 53, 23-34.
5. Bouillet, P., Chazaud, C., Oulad-Abdelghani, M., Dolle, P. and Chambon, P. (1995). Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells. Dev. Dynam. 204, 372-382.
6. Brand, M., Heisenberg, C., Jiang, Y., Beuchle, D., Lun, K., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D., Kelsh, R., Mullins, M., Odenthal, J., van Eeden, F. and Nusslein-Volhard, C. (1996). Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development 123, 179-190.
7. Bulfone, A., Puelles, L., Porteus, M. H., Frohman, M. A., Martin, G. R. and Rubenstein, J. L. R. (1993). Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse fore brain defines potential transverse and longitudinal segmental boundaries. J. Neurosci. 13, 3155-3172.
8. Chapman, G. and Rathjen, P. (1995). Sequence and evolutionary conservation of the murine Gbx-2 homeobox gene. FEBS Lett. 364, 289-292.
9. Chiang, C., Young, K. and Beachy, P. (1995). Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax complex. Development 121, 3901-3912.
10. Couly, G., Grapin-Botton, A., Coltey, P. and Le Douarin, N. (1996). The regeneration of the cephalic neural crest, a problem revisited: the regenerating cells originate from the contralateral or from the anterior and posterior neural fold. Development 122, 3393-3407.
11. Crossley, P., Martinez, S. and Martin, G. (1996). Midbrain development induced by FGF8 in the chick embryo. Nature 380, 66-68.
12. Crossley, P. H. and Martin, G. R. (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439-451.
13. Danielian, P. and McMahon, A. (1996). Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383, 332-334.
14. Davis, C. A. and Joyner, A. L. (1988). Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes Dev 2, 1736-1744.
15. Donoghue, M., Lewis, R., Merlie, J. and Sanes, J. (1996). The Eph kinase ligand AL-1 is expressed by rostral muscles and inhibits outgrowth from caudal neurons. Mol. Cell. Neuosci. 8, 185-198.
16. Favor, J., Sandulache, R., Neuhauser-Klaus, A., Pretsch, W., Chatterjee, B., Senft, E., Wurst, W., Blanquet, V., Grimes, P., Sporle, R. and Schughart, K. (1996). The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney. Proc. Natl. Acad. Sci. USA 93, 13870-13875.
17. Flenniken, A. M., Gale, N. W., Yancopoulos, G. D. and Wilkinson, D. G. (1996). Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis. Dev. Biol. 179, 382-401.
18. Frohman, M. A., Boyle, M. and Martin, G. R. (1990). Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior posterior axis is specified by mesoderm. Development 110, 589-607.
19. Gilland, E. and Baker, R. (1993). Conservation of neuroepithelial and mesodermal segments in the embryonic vertebrate head. Acta Anat. 148, 110-123
20. Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B. and Joyner, A. L. (1995). Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269, 679-682.
21. Heikinheimo, M., Lawshé, A., Shackleford, G. M., Wilson, D. B. and MacArthur, C. A. (1994). Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs, and central nervous system. Mech. Dev. 48, 129-138.
22. Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J. and Ish-Horowicz, D. (1995). Expression of a Delta homologue in prospective neurons in the chick. Nature 375, 787-790.
23. Hui, C. and Joyner, A. (1993). A mouse model of Greig cephalopolysyndactyly syndrome: the extra-toes mutation contains an intragenic deletion of the Gli3 gene. Nature Genet. 3, 241-246.
24. Joyner, A. L. (1996). Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development. Trends Genet. 12, 15-20.
25. Karnovsky, M. and Roots, L. (1964). A direct coloring thiocholine method for cholinestereases. J. Histochem. Cytochem. 12, 219-221.
26. Kaufman, M. H. (1994). The Atlas of Mouse Development. San Diego, CA: Academic Press.
27. Kilby, N. J., Snaith, M. R. and Murray, J. A. (1993). Site-specific recombinases: tools for genome engineering. Trends Genet. 9, 413-421.
28. Köntges, G. and Lumsden, A. (1996). Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny. Development 122, 3229-3242.
29. Lee, S. M. K., Danielian, P. S., Fritzsch, B. and McMahon, A. P. (1997). Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development 124, 959-969.
30. Lewandoski, M., Wassarman, K. M. and Martin, G. R. (1997). Zp3-cre. a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr. Biol. 7, 148-151.
31. Lumsden, A. and Krumlauf, R. (1996). Patterning the vertebrate neuraxis. Science 274, 1109-1115.
32. Mahmood, R., Bresnick, J., Hornbruch, A., Mahony, C., Morton, N., Colquhoun, K., Martin, P., Lumsden, A., Dickson, C. and Mason, I. (1995). A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr. Biol. 5, 797-806.
33. Marin, F. and Puelles, L. (1995). Morphological fate of rhombomeres in quail/chick chimeras: a segmental analysis of hindbrain nuclei. Eur. J. Neurosci. 7, 1714-1738.
34. Martinez, S., Wassef, M. and Alvarado-Mallart, R.-M. (1991). Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en. Neuron 6, 971-981.
35. Matsui, T., Hirai, M., Hirano, M. and Kurosawa, Y. (1993). The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. FEBS Lett. 336, 107-110.
36. McLeod, M. J. (1980). Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red. Teratology 22, 299-301.
37. McMahon, A., Joyner, A., Bradley, A. and McMahon, J. (1992). The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1-mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum, Cell 69, 581-595.
38. McMahon, A. P. and Bradley, A. (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085.
39. Meinhardt, H. (1983). Cell determination boundaries as organizing regions for secondary embryonic fields. Dev. Biol. 96, 375-385.
40. Millet, S., Bloch-Gallego, E., Simeone, A. and Alvarado-Mallart, R.-M. (1996). The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts. Development 122, 3785-3797.
41. Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. and Roder, J. C. (1993). Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90, 8424-8428.
42. Ohuchi, H., Yoshioka, H., Tanaka, A., Kawakami, Y., Nohno, T. and Noji, S. (1994). Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis. Biochem. Biophys. Res. Comm. 204, 882-888.
43. Osumi-Yamashita, N., Ninomiya, Y., Doi, H. and Eto, K. (1996). Rhombomere formation and hindbrain crest cell migration from prorhombomeric origins in mouse embryos. Dev. Growth Differ. 38, 107-118.
44. Puelles, L., Marin, F., Martinez de la Torre, M. and Martinez, S. (1996). The midbrain-hindbrain junction: a model system for brain regionalization through morphogenetic neuroepithelial interactions. In Mammalian Development (ed. P. Lonai), Gordon & Breach/Harwood Academic Publishers.
45. Rétaux, S. and Harris, W. (1996). Engrailed and retinotectal topography. Trends Neurosci. 19, 542-546.
46. Rubenstein, J. L. R. and Shimamura, K. (1997). Regulation of patterning and differentiation in the embryonic vertebrate forebrain. In Neuronal Development (ed. W. M. Cowan, T. M. Jessell and S. L. Zipursky) Oxford: Oxford University Press.
47. Siegfried, E. and Perrimon, N. (1994). Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling. BioEssays 16, 395-404.
48. Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A. and Boncinelli, E. (1992). Nested expression domains of four homeobox genes in developing rostral brain. Nature 358, 687-690.
49. Simeone, A., Acampora, D., Mallamaci, A., Stornaiuolo, A., D'Apice, M., Nigro, V. and Boncinelli, E. (1993). A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J. 12, 2735-2747.
50. Song, D., Chalepakis, G., Gruss, P. and AL, J. (1996). Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene. Development 122, 627-635.
51. Suda, Y., Matsuo, I., Kuratani, S. and Aizawa, S. (1996). Otx1 function overlaps with Oix2 in development of mouse forebrain and midbrain. Genes to Cells 1, 1031-1044.
52. Sutherland, D., Samakovlis, C. and Krasnow, M. (1996). branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Cell 87, 1091-1101.
53. Thomas, K. R. and Capecchi, M. R. (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346, 847-850.
54. Tybulewicz, V. L., Crawford, C. E., Jackson, P. K., Bronson, R. T. and Mulligan, R. C. (1991). Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153-1163.
55. Urbanek, P., Wang, Z., Fetka, I., Wagner, E. and Busslinger, M. (1994). Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79, 901-912.
56. von Bubnoff, A., Schmidt, J. and Kimelman, D. (1995). The Xenopits laevis homeobox gene Xgbx-2 is an early marker of anteroposterior patterning in the ectoderm. Mech. Dev. 54, 149-160.
57. Wassef, M., Zanetta, J., Brehier, A. and Sotelo, C. (1985). Transient biochemical compartmentalization of Purkinje cells during early cerebellar development. Dev. Biol. 111, 129-137.
58. Wilkinson, D. G., Bhatt, S., Chavrier, P., Bravo, R. and Charnay, P. (1989a). Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse. Nature 337, 461-464.
59. Wilkinson, D. G., Bhatt, S., Cook, M., Boncinelli, E. and Krumlauf, R. (1989b). Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature 341, 405-409.
60. Wurst, W., Auerbach, A. and Joyner, A. (1994). Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120, 2065-2075.
61. Wurst, W. and Joyner, A. L. (1993). Production of targeted embryonic stem cell clones. In Gene Targeting, A Practical Approach, (ed. A. L. Joyner), pp. 33-61. Oxford, UK: IRL Press.