The bacterial regulatory protein H-NS-A versatile modulator of nucleic acid structures

Biological Chemistry

Volumn 383, Issue 6, 2002, Pages 945-960

  Schröder, Oliver ^a   Wagner, Rolf ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

DNA binding protein; Gene expression; Histone like protein; Nucleoprotein structure; Post transcriptional regulation; Transcriptional regulation

Indexed keywords

BACTERIAL PROTEIN; DNA BINDING PROTEIN; LIGAND; PROTEIN HNS; REGULATOR PROTEIN; RNA; UNCLASSIFIED DRUG;

BIOPHYSICS; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; GENE ACTIVITY; GROWTH REGULATION; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; NUCLEIC ACID STRUCTURE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; REVIEW; RNA STRUCTURE; STRUCTURE ANALYSIS; THERMOREGULATION; TRANSLATION REGULATION;

BACTERIAL PHYSIOLOGY; DNA, BACTERIAL; DNA-BINDING PROTEINS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION;

BACTERIA (MICROORGANISMS);

EID: 0036332716     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.101     Document Type: Review

References (135)

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2. Conformational changes of the upstream DNA mediated by H-NS and FIS regulate E. coli rrnB P1 promoter activity
3. Sigma S-dependent growth-phase induction of the csgBA promoter in Escherichia coli can be achieved in vivo by sigma 70 in the absence of the nucleoid-associated protein H-NS
4. The histone-like protein H-NS acts as a transcriptional repressor for expression of the anaerobic and growth phase activator AppY of Escherichia coli
5. H-NS: A modulator of environmentally regulated gene expression
6. Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid
7. Role for the histone-like protein H-NS in growth phase-dependent and osmotic regulation of sigma S and many sigma S-dependent genes in Escherichia coli
8. Transcriptional regulation of the esp genes of enterohemorrhagic Escherichia coli
9. The H-NS protein is involved in the biogenesis of flagella in Escherichia coli
10. The structural and functional organization of H-NS-like proteins is evolutionarily conserved in gram-negative bacteria
11. H-NS and H-NS-like proteins in Gram-negative bacteria and their multiple role in the regulation of bacterial metabolism
12. Synthetic curved DNA sequences can act as transcriptional activators in Escherichia coli
13. Massive presence of the Escherichia coli 'major cold-shock protein' CspA under non-stress conditions
14. Suppression of FNR-dependent transcription activation at the Escherichia coli nir promoter by Fis, lHF and H-NS: Modulation of transcription initiation by a complex nucleo-protein assembly
15. Lac and lambda repressors relieve silencing of the Escherichia coli bgl promoter. Activation by alteration of a repressing nucleoprotein complex
16. Antagonistic control of the Escherichia coli bgl promoter by FIS and CAP in vitro
17. Multimeric self-assembly equilibria involving the histone-like protein H-NS. A thermodynamic study
18. H-NS is a repressor of the Proteus mirabilis urease transcriptional activator gene ureR
19. Control site location and transcriptional regulation in Escherichia coli
20. Domain structure and RNA annealing activity of the Escherichia coli regulatory protein StpA
21. H-NS mediated compaction of DNA visualised by atomic force microscopy
22. Structural basis for preferential binding of H-NS to curved DNA
23. Structural basis for H-NS-mediated trapping of RNA polymerase in the open initiation complex at the rrnB P1
24. The response to stationary-phase stress conditions in Escherichia coli: Role and regulation of the glutamic acid decarboxylase system
25. A role for the Escherichia coli H-NS-like protein StpA in OmpF porin expression through modulation of micF RNA stability
26. Synthesis of the Escherichia coli K-12 nucleoid-associated DNA-binding protein H-NS is subjected to growth-phase control and autoregulation
27. The nucleoid-associated DNA-binding protein H-NS is required for the efficient adaptation of Escherichia coli K-12 to a cold environment
28. Enhanced binding of altered H-NS protein to flagellar rotor protein FliG causes increased flagellar rotational speed and hypermotility in Escherichia coli
29. Phenotypic analysis of random hns mutations differentiate DNA-binding activity from properties of fimA promoter inversion modulation and bacterial motility
30. Promoter-specific repression of fimB expression by the Escherichia coli nucleoid-associated protein H-NS
31. Domain organization and oligomerization among H-NS-like nucleoid-associated proteins in bacteria
32. Escherichia coli DNA-binding protein H-NS is localized in the nucleoid
33. Proteins from the prokaryotic nucleoid: Primary and quaternary structure of the 15-kD Escherichia coli DNA binding protein H-NS
34. Expression of the gene encoding the major bacterial nucleotide protein H-NS is subject to transcriptional autorepression
35. Antagonistic involvement of FIS and H-NS proteins in the transcriptional control of hns expression
36. Thermoregulation of Shigella and Escherichia coli EIEC pathogenicity. A temperature-dependent structural transition of DNA modulates accessibility of virF promoter to transcriptional repressor H-NS
37. Expression of the endogenous type II secretion pathway in Escherichia coli leads to chitinase secretion
38. Coupling of Escherichia coli hns mRNA levels to DNA synthesis by autoregulation: Implications for growth phase control
39. The Escherichia coli stpA gene is transiently expressed during growth in rich medium and is induced in minimal medium and by stress conditions
40. The StpA protein functions as a molecular adapter to mediate repression of the bgl operon by truncated H-NS in Escherichia coli
41. Proteins from the prokaryotic nucleoid. Interaction of nucleic acids with the 15 kDa Escherichia coli histone-like protein H-NS
42. Role of activator site position and a distal UP-element half-site for sigma factor selectivity at a CRP/H-NS-activated sigma-dependent promoter in Escherichia coli
43. Mutagenesis of the downstream region of the Escherichia coli hns promoter
44. IHF supresses the inhibitory effect of H-NS on HU function in the hin inversion system
45. Interplay between three global regulatory proteins mediates oxygen regulation of the Escherichia coli cytochrome d oxidase (cydAB) operon
46. Organization and function of transcription regulatory elements
47. Interplay of global regulators and cell physiology in the general stress response of Escherichia coli
48. Expression and mutational analysis of the nucleoid-associated protein H-NS of Salmonella typhimurium
49. Large-scale monitoring of pleiotropic regulation of gene expression by the prokaryotic nucleoid-associated protein, H-NS
50. Poly(3-hydroxybutyrate) is associated with specific proteins in the cytoplasm and membranes of Escherichia coli
51. Temperature sensing in bacterial gene regulation-what it all boils down to
52. Differential protease-mediated turnover of H-NS and StpA revealed by a mutation altering protein stability and stationary-phase survival of Escherichia coli
53. H-NS and StpA proteins stimulate expression of the maltose regulon in Escherichia coli
54. Nucleoid proteins stimulate stringently controlled bacterial promoters: A link between the cAMP-CRP and the (p)ppGpp regulons in Escherichia coli
55. Heteromeric interactions among nucleoid-associated bacterial proteins: Localization of StpA-stabilizing regions in H-NS of Escherichia coli
56. The downstream regulatory element of the proU operon of Salmonella typhimurium inhibits open complex formation by RNA polymerase at a distance
57. The positive regulator CfaD overcomes the repression mediated by histone-like protein H-NS (1-11) in the CFA/l fimbrial operon of Escherichia coli
58. DNA binding is not sufficient for H-NS-mediated repression of proU expression
59. Two novel flagellar components and H-NS are involved in the motor function of Escherichia coli
60. Autogenous and global control of the flagellar master operon, flhD, in Salmonella typhimurium
61. Identification of a cold shock transcriptional enhancer of the Escherichia coli gene encoding nucleoid protein H-NS
62. 1H NMR studies on three bacterial histone-like proteins
63. The Escherichia coli DNA-binding protein H-NS is one of the first proteins to be synthesized after a nutritional upshift
64. Role of Escherichia coli histone-like nucleoid-structuring protein in bacterial metabolism and stress response-identification of targets by two-dimensional electrophoresis
65. Riboregulation by DsrA RNA: Trans-actions for global economy
66. A trans-acting RNA as a control switch in Escherichia coli: DsrA modulates function by forming alternative structures
67. Riboregulation in Escherichia coli: DsrA RNA acts by RNA:RNA interactions at multiple loci
68. Gene 5.5 protein of bacteriophage T7 inhibits the nucleoid protein H-NS of Escherichia coli
69. Regulation in the rpoS regulon of Escherichia coli
70. Adaptation of Escherichia coli to high osmolarity environments: Osmoregulation of the high-affinity glycine betaine transport system ProU
71. DsrA RNA regulates translation of RpoS message by an anti-antisense mechanism, independent of its action as an antisilencer of transcription
72. s and requires activation by cAMP-CRP
73. Interacting components of the flagellar motor of Escherichia coli revealed by the two-hybrid system in yeast
74. H-NS over-expression induces an artificial stationary phase by silencing global transcription
75. In vivo supercoiling of plasmid and chromosomal DNA in an Escherichia coli hns mutant
76. The RNA-binding protein HF-I, known as a host factor for phage Qβ RNA replication, is essential for rpoS translation in Escherichia coli
77. Characterization of the negative elements involved in silencing the bgl operon of Escherichia coli: Possible roles for DNA gyrase, H-NS, and CRP-cAMP in regulation
78. Expression of the hemolysin operon in Escherichia coli is modulated by a nucleoid-protein complex that includes the proteins Hha and H-NS
79. Fis-dependent trans -activation of stable RNA operons of Escherichia coli under various growth conditions
80. Post-transcriptional control by global regulators of gene expression in bacteria
81. Vibrio cholerae H-NS silences virulence gene expression at multiple steps in the ToxR regulatory cascade
82. Effects of local transcription and H-NS on inversion of the fim switch of Escherichia coli
83. Identification of genetic factors altering the SOS induction of DNA damage-inducible yebG gene in Escherichia coli
84. Differential temperature modulation by H-NS of the fimB and fimE recombinase genes which control the orientation of the type 1 fimbrial phase switch
85. Regulation of Irp gene expression by H-NS and Lrp proteins in Escherichia coli: Dominant negative mutations in Irp
86. The chromatin-associated protein H-NS interacts with curved DNA to influence DNA topology and gene expression
87. H-NS regulates DNA repair in Shigella
88. A role for H-NS in the thermo-osmotic regulation of virulence gene expression in Shigella flexneri
89. A role for H-NS in the regulation of the virF gene of Shigella and enteroinvasive Escherichia coli
90. Structural characterization of the N-terminal oligomerization domain of the bacterial chromatin-structuring protein, H-NS
91. Low molecular weight complexed poly(3-hydroxybutyrate): A dynamic and versatile molecule in vivo
92. Mechanisms of transcriptional repression
93. Regulation of the Escherichia coli K5 capsule gene cluster: Evidence for the roles of H-NS, BipA, and integration host factor in regulation of group 2 capsule gene clusters in pathogenic E coli
94. The bacterial DNA-binding protein H-NS represses ribosomal RNA transcription by trapping RNA polymerase in the initiation complex
95. Towards the three-dimensional structure of the E coli DNA-binding protein H-NS: A CD- and fluorescence study
96. Suppression of gamma ray-induced illegitimate recombination in Escherichia coli by the DNA-binding protein H-NS
97. Plasmids bearing hfq and the hns-like gene stpA complement hns mutants in modulating arginine decarboxylase gene expression in Escherichia coli
98. Involvement of H-NS in transpositional recombination mediated by IS1
99. Solution structure of the DNA binding domain of a nucleoid-associated protein, H-NS, from Escherichia coli
100. Identification of the DNA binding surface of H-NS protein from Escherichia coli by heteronuclear NMR spectroscopy
101. A small RNA acts as an antisilencer of the H-NS-silenced rcsA gene of Escherichia coli
102. Hfq is necessary for regulation by the untranslated RNA DsrA
103. Oligomerization of the chromatin-structuring protein H-NS
104. Coordinated and differential expression of histone-like proteins in Escherichia coli: Regulation and function of the H-NS analog StpA
105. The nucleoid-associated protein StpA binds curved DNA, has a greater DNA-binding affinity than H-NS and is present in significant levels in hns mutants
106. Physico-chemical properties of a DNA binding protein: Escherichia coli factor H1
107. H1a, an E. coli DNA-binding protein which accumulates in stationary phase, strongly compacts DNA in vitro
108. The oligomeric structure of nucleoid protein H-NS is necessary for recognition of intrinsically curved DNA and for DNA bending
109. Proteins shared by the transcription and translation machines
110. H-NS regulates OmpF expression through micF antisense RNA in Escherichia coli
111. Fluorescence analysis of the Escherichia coli transcription regulator H- NS reveals two distinguishable complexes dependent on binding to specific or nonspecific DNA sites
112. Evidence for a regulatory function of the histone-like Escherichia coli protein H-NS in ribosomal RNA synthesis
113. Temperature regulation of heat-labile enterotoxin (LT) synthesis in Escherichia coli is mediated by an interaction of H-NS protein with the LT A-sub-unit DNA
114. The chromatin-associated protein H-NS alters DNA topology in vitro
115. The Escherichia coli nucleoid protein H-NS functions directly as a transcriptional repressor
116. Autoregulatory expression of the Escherichia coli hns gene encoding a nucleoid protein: H-NS functions as a repressor of its own transcription
117. Systematic mutational analysis revealing the functional domain organization of Escherichia coli nucleoid protein H-NS
118. Clarification of the dimerization domain and its functional significance for the Escherichia coli nucleoid protein H-NS
119. H-NS protein represses transcription of the lux systems of Vibrio fischeri and other luminous bacteria cloned into Escherichia coli
120. The chromatin-associated protein H-NS
121. Leucine-responsive regulatory protein plays dual roles as both an activator and a repressor of the Escherichia coli pap fimbrial operon
122. Integration host factor alleviates the H-NS-mediated repression of the early promoter of bacteriophage Mu
123. Ribosomes as sensors of heat and cold shock in Escherichia coli
124. Histone-like proteins in the purified Escherichia coli desoxyribonucleoprotein
125. The regulation of ribosomal RNA synthesis and bacterial cell growth
126. Silencing and activation of ClyA cytotoxin expression in Escherichia coli
127. Thermoregulation of Escherichia coli pap transcription: H-NS is a temperature-dependent DNA methylation blocking factor
128. Molecular aspects of the E. coli nucleoid protein, H-NS: A central controller of gene regulatory networks
129. Probing the structure, function, and interactions of the Escherichia coli H-NS and StpA proteins by using dominant negative derivatives
130. An Escherichia coli protein that preferentially binds to sharply curved DNA
131. Molecular analysis of the Escherichia coli hns gene encoding a DNA- binding protein, which preferentially recognizes curved DNA sequences
132. Quantitative control of the stationary phase-specific sigma factor, sigma S, in Escherichia coli: Involvement of the nucleoid protein H-NS
133. Nucleotide sequence of a newly-identified Escherichia coli gene, stpA, encoding an H-NS-like protein
134. Escherichia coli protein analogs StpA and H-NS: Regulatory loops, similar and disparate effects on nucleic acid dynamics
135. Modulated expression of promoters containing upstream curved DNA sequences by the Escherichia coli nucleoid protein H-NS