Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer

Journal of Neuroscience

Volumn 19, Issue 14, 1999, Pages 6027-6036

  Hashimoto, Kouichi ^a,b,c   Fukaya, Masahiro ^d   Qiao, Xiaoxi ^e   Sakimura, Kenji ^f   Watanabe, Masahiko ^d   Kano, Masanobu ^b,c  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f NIIGATA UNIVERSITY   (Japan)

Author keywords

AMPA receptor; Ataxia; BDNF; Cerebellum; Granule cell; Mossy fiber; Mutant mouse; Stargazer; Synaptic transmission

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; N METHYL DEXTRO ASPARTIC ACID; TYROSINE KINASE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CONTROLLED STUDY; EYELID REFLEX; GENE MUTATION; GRANULE CELL; HIPPOCAMPUS; MOSSY FIBER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SYNAPTIC TRANSMISSION;

EID: 0033565945     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-14-06027.1999     Document Type: Article

References (41)

1. Aiba A, Kano M, Chen C, Stanto, ME, Fox GD, Herrup K, Zwingman TA, Tonegawa S (1994) Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell 79:377-388.
2. Boulter J, Hollmann M, O'Shea-Greenfield A, Hartley M, Deneris E, Maron C, Heinemann S (1990) Molecular cloning and functional expression of glutamate receptor subunit genes. Science 249:1033-1037.
3. D'Angelo E, Rossi P, Taglietti V (1994) Voltage-dependent kinetics of N-methyl-D-aspartate synaptic currents in rat cerebellar granule cells. Eur J Neurosci 6:640-645.
4. D'Angelo E, De Filippi G, Rossi P, Taglietti V (1995) Synaptic excitation of individual rat cerebellar granule cells in situ: evidence for the role of NMDA receptors. J Physiol (Lond) 484:397-413.
5. Di Pasquale E, Keegan KD, Noebels JL (1997) Increased excitability and inward rectification in layer V cortical pyramidal neurons in epileptic mutant mouse stargazer. J Neurophysiol 77:621-631.
6. Dong H, O'Brien RJ, Fung ET, Lanahan AA, Worley PF, Huganir RL (1997) GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 386:279-284.
7. Ebradlidze AK, Rossi DJ, Tonegawa S, Slater NT (1996) Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene. J Neurosci 16:5014-5025.
8. Edwards FA, Konnerth A, Sakmann B, Takahashi T (1989) A thin slice preparation for patch-clamp recordings from neurons of the mammalian central nervous system. Pflügers Arch 414:600-612.
9. Ernfors P, Lee KF, Jaenisch R (1994) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368:147-150.
10. Farrant M, Feldmeyer D, Takahashi T, Cull-Candy SG (1994) NMDA-receptor channel diversity in the developing cerebellum. Nature 368:335-339.
11. Figurov A, Pozzo Miller LD, Olafsson P, Wang T, Lu B (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381:706-709.
12. Hayashi T, Umemori H, Mishina M, Yamamoto T (1999) The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn. Nature 397:72-76.
13. Ito M (1984) The cerebellum and neural control. New York: Raven.
14. Jones KR, Farinas I, Backus C, Reichardt LF (1994) Targeted disruption of the BDN F gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76:989-999.
15. Kang H, Schuman EM (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267:1658-1662.
16. Kano M, Konnerth A (1992) Cerebellar slices for patch clamp recording. In: Practical electrophysiological methods (Kettenmann H, Grantyn R, eds), pp 54-57. New York: Wiley-Liss.
17. Kawamoto S, Hattori S, Sakimura K, Mishina M, Okuda K (1995) N-linked glycosylation of the alpha-amino 3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-selective glutamate receptor channel alpha 2 subunit is essential for the acquisition of ligand-binding activity. J Neurochem 64:1258-1266.
18. Keinänen K, Wisden W, Sommer B, Werner P, Herb S, Verdoorn TA, Sakmann B, Seeburg PH (1990) A family of AMPA-selective glutamate receptors. Science 249:556-560.
19. Kim JJ, Thompson RF (1997) Cerebellar circuits and synaptic mechanisms involved in classical eyeblink conditioning. Trends Neurosci 20:177-181.
20. Lessmann V, Gottmann K, Heumann R (1994) BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones. NeuroReport 6:21-25.
21. 2+-channel y subunit. Nat Genet 19:340-347.
22. Llano I, Marty A, Armstrong CM, Konnerth A (1991) Synaptic- and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slice. J Physiol (Lond) 434:183-213.
23. Lohof AM, Ip NY, Poo MM (1993) Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature 363:350-353.
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
25. 2+ of NMDA responses in spinal cord neurones. Nature 309:261-263.
26. Noebels JL, Qiao X, Bronson RT, Spencer C, Davisson MT (1990) Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures. Epilepsy Res 7:129-135.
27. Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A (1984) Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307:462-465.
28. Patterson SL, Abel T, Deuel TA, Martin KC, Rose JC, Kandel ER (1996) Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16:1137-1145.
29. Qiao X, Hefti F, Knusel B, Noebels JL (1996) Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia. J Neurosci 16:640-648.
30. Qiao X, Chen L, Gao H, Bao S, Hefti F, Thompson RF, Knusel B (1998) Cerebellar brain-derived neurotrophic factor-TrkB defect associated with impairment of eyeblink conditioning in stargazer mutant mice. J Neurosci 18:6990-6999.
31. Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL (1996) Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. Neuron 16:1179-1188.
32. Sakimura K, Bujo H, Kushiya E, Araki K, Yamazaki M, Yamazaki M, Meguro H, Warashina A, Numa S, Mishina M (1990) Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett 272:73-80.
33. Scanziani M, Salin PA, Vogt KE, Malenka RC, Nicoll RA (1997) Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors. Nature 385:630-634.
34. Srivastava S, Osten P, Vilim FS, Khatri L, Inman G, States B, Daly C, DeSouza S, Abagyan R, Valtschanoff JG, Weinberg RJ, Ziff EB (1998) Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Neuron 21:581-591.
35. Takahashi T, Feldmeyer D, Suzuki N, Onodera K, Cull-Candy SG, Sakimura K, Mishina M (1996) Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum. J Neurosci 16:4376-4382.
36. Tanaka T, Saito H, Matsuki N (1997) Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus. J Neurosci 17:2959-2966.
37. Tempia F, Kano M, Schneggenburger R, Schirra C, Garaschuk O, Plant T, Konnerth A (1996) Fractional calcium current through neuronal AMPA-receptor channels with a low calcium permeability. J Neurosci 15:456-466.
38. Thompson RF (1986) The neurobiology of learning and memory. Science 233:941-947.
39. 2+ channels: role in channel function. Trends Neurosci 21:148-154.
40. Watanabe M, Inoue Y, Sakimura K, Mishina M (1993) Distinct distributions of five NMDA receptor channel subunit mRNAs in the forebrain. J Comp Neurol 338:377-390.
41. Yeo CH, Hesslow G (1998) Cerebellum and conditioned reflexes. Trends Cognit Sci 2:322-330.