Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase β1 subunit gene

Journal of Clinical Investigation

Volumn 102, Issue 7, 1998, Pages 1421-1430

  Factor, Phillip ^a,b   Saldias, Fernando ^a   Ridge, Karen ^a,b   Dumasius, Vidas ^a   Zabner, Joseph ^c   Jaffe, H Ari ^b   Blanco, Gustavo ^d   Barnard, Michele ^a,b   Mercer, Robert ^d   Perrin, Richard ^a   Sznajder, Jacob I ^a,b  

^a MICHAEL REESE HOSPITAL   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenovirus; Gene transfer; Lung epithelial cells; Lung liquid clearance; Na,K ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BETA GALACTOSIDASE; COMPLEMENTARY DNA; LUNG SURFACTANT; OUABAIN;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME SUBUNIT; GENE TRANSFER; LUNG ALVEOLUS; LUNG CLEARANCE; LUNG EDEMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0032190597     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3214     Document Type: Article

References (56)

1. Matthay, M.A., C.C. Landolt, and N.C. Staub. 1982. Differential liquid and protein clearance from the alveoli of anesthetized sheep. J. Appl. Physiol. 53:96-104.
2. Rutschman, D.H., W. Olivera, and J.I. Sznajder. 1993. Active transport and passive liquid movement in isolated perfused rat lungs. J. Appl. Physiol. 75: 1574-1580.
3. Goodman, B.E., K. Kim, and E.D. Crandall. 1987. Evidence for active sodium transport across alveolar epithelium of isolated rat lung. J. Appl. Physiol. 62:2460-2466.
4. Berthiaume, Y., N.C. Staub, and M.A. Matthay. 1987. β-adrenergic agonists increase lung liquid clearance in anesthetized sheep. J. Clin. Invest. 79: 335-343.
5. Olivera, W., K. Ridge, L.D.H. Wood, and J.I. Sznajder. 1994. Active sodium transport and alveolar epithelial Na,K-ATPase increase during subacute hyperoxia in rats. Am. J. Physiol. 266:L577-L584.
6. Skou, J.C., and M. Esmann. 1992. The Na,K-ATPase. J. Bioenerg. Biomembr. 24:249-261.
7. Ridge, K.M., D.H. Rutschman, P. Factor, A.I. Katz, A.M. Bertorello, and J.L. Sznajder. 1997. Differential expression of Na-K-ATPase isoforms in rat alveolar epithelial cells. Am. J. Physiol. 273:L246-L255.
8. 2 subunit in lung liquid clearance. In Acute Respiratory Distress Syndrome: Cellular and Molecular Mechanisms and Clinical Management. S. Matalon, and J.I. Sznajder, editors. Plenum, New York. 69-70.
9. Schneeberger, E.E., and K.M. McCarthy. 1986. Cytochemical localization of Na, K-ATPase in rat type II pneumocytes. J. Appl. Physiol. 20:1584-1589.
10. Nici, L., R. Dowin, M. Gilmore-Hebert, J.D. Jamieson, and D.H. Ingbar. 1991. Response of rat Type II pneumocyte Na,K-ATPase to hyperoxic injury. Am. J. Physiol. 261:L307-L314.
11. + transport by lung epithelium in the clearance of airspace fluid. New Horizons. 3:240-247.
12. + conductance in adult alveolar pneumocytes. Am. J. Physiol. 262:C1228-C1238.
13. Matthay, M., H.G. Folkesson, and A.S. Verkman. 1996. Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am. J. Physiol. 270:L487-L503.
14. Olivera, W.G., K.M. Ridge, and J.I. Sznajder. 1995. Lung liquid clearance and Na,K-ATPase during acute hyperoxia and recovery in rats. Am. J. Resp. Crit. Care Med. 152:1229-1234.
15. Sznajder, J.I., W.G. Olivera, K.M. Ridge, and D.H. Rutschman. 1995. Mechanisms of lung liquid clearance during hyperoxia in isolated rat lungs. Am. J. Resp. Crit. Care Med. 151:1519-1525.
16. Barnard, M.L., W.G. Olivera, D.M. Rutschman, A.M. Bertorello, A.I. Katz, and J.I. Sznajder. 1997. Dopamine stimulates sodium transport and liquid clearance in rat lung epithelium. Am. J. Resp. Crit. Care Med. 156:709-714.
17. Tibayan, F.A., A.N. Chesnutt, H.G. Folkesson, J. Eandi, and M.A. Matthay. 1997. Dobutamine increases alveolar liquid clearance in ventilated rats by β2 receptor stimulation. Am. J. Resp. Crit. Care. Med. 156:438-444.
18. Saldias, F., E. Lecuona, E. Friedman, M.L. Barnard, K.M. Ridge, and J.I. Sznajder. 1998. Modulation of lung liquid clearance by isoproterenol in rat lungs. Am. J. Physiol. 274:L694-L701.
19. 1 subunit increases Na,K-ATPase function in A549 cells. Am. J. Respir. Cell Mol. Biol. 18:741-749.
20. McGrory, W.J., D.S. Bautista, and F.L. Graham. 1988. A simple technique for the rescue of early region 1 mutations into infectious human adenovirus type 5. Virology. 163:614-617.
21. Rosenfeld, M.A., C. Chin-Shyan, P. Seth, C. Danel, T. Banks, K. Yoneyama, K. Yoshimura, and R.G. Crystal. 1994. Gene transfer to isolated human respiratory epithelial cells in vitro using a replication-deficient adenovirus containing the human cystic fibrosis transmembrane conductance regulator cDNA. Hum. Gene Ther. 5:331-342.
22. Dobbs, L.G., R. Gonzalez, and M.C. Williams. 1986. An improved method for isolating type 2 cells in high yield and purity. Am. Rev. Respir. Dis. 134:141-145.
23. - transport in cystic fibrosis airway epithelia in vitro: effect of promoter and administration method. Gene Ther. 3:458-465.
24. Zabner, J., E.G. Zeiher, E. Friedman, and M.J. Welsh. 1996. Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time. J. Virol. 70:6994-7003.
25. Factor, P., C. Senne, K. Ridge, H.A. Jaffe, and J.I. Sznajder. 1997. Differential effects of adenoviral-mediated transfer of Na,K-ATPase subunit genes in lung epithelial cells. Chest. 111:110S-111S.
26. Katkin, J., R. Husser, C. Langston, and S. Welty. 1997. Exogenous surfactant enhances the delivery of recombinant adenoviral vectors to the lung. Hum. Gene Ther. 8:171-176.
27. Jaffe, H.A., C. Danel, G. Longnecker, M. Metzger, Y. Setoguchi, M.A. Rosenfeld, T.W. Gant, S.S. Thorgeirsson, L.D. Stratford-Perricaudet, M. Perricaudet, A. Pavirani, J. Lecocq, and R.G. Crystal. 1992. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat. Genet. 1:372-378.
28. Mastrangeli, A., C. Danel, M.A. Rosenfeld, L.D. Stratford-Perricaudet, M. Perricaudet, A. Pavirani, J. Lecocq, and R.G. Crystal. 1993. Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer. J. Clin. Invest. 91:225-234.
29. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Ann. Biochem. 162:156-159.
30. + channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning. Proc. Natl. Acad. Sci. USA. 91:247-251.
31. Basset, G., C. Crone, and G. Saumon. 1987. Significance of active ion transport in transalveolar water absorption: a study on isolated rat lung. J. Physiol. (Lond). 384:335-343.
32. Zhang, X.L., S.J. Danto, J. Eber, Z. Borok, P. Martin-Vasallo, and R.L. Lubman. 1997. Identification of Na,K-ATPase b-subunit in alveolar epithelial cells. Am. J. Phsyiol. 272:L85-L94.
33. Lingrel, J.B., R.M. Young, and M.M. Shull. 1988. Multiple forms of the Na,K ATPase: their genes and tissue specific expression. In The Na,K ATPase pump. J. Skou, J. Norby, A. Mansbach, and M. Esman, editors. Alan R. Liss, New York. 105-112.
34. DeTomaso, A.W., Z.J. Xie, G. Liu, and R.W. Mercer. 1993. Expression, targeting, and assembly of functional Na,K-ATPase polypeptides in baculovirus infected cells. J. Biol. Chem. 268:1470-1478.
35. Chow, D.C., and J.G. Forte. 1995. Functional significance of the β-subunit for heterodimeric P-type ATPases. J. Exp. Biol. 198:1-17.
36. Fambrough, D.M., M.V. Lemas, M. Hamrick, M. Emerick, K.J. Ranaud, E.M. Inman, B. Hwang, and K. Takeyasu. 1994. Analysis of subunit assembly of the Na,K-ATPase. Am. J. Physiol. 266:C579-C589.
37. Jaisser, F., P. Jaunin, K. Geering, B.C. Rossier, and J.D. Horisberger. 1994. Modulation of the Na,K-pump function by β subunit isoforms. J. Gen. Physiol. 103:605-623.
38. + increases Na,K-ATPase abundance in LLC-PK1/C14 cells by differentially increasing β and not a subunit mRNA. J. Biol. Chem. 265:17935-17940.
39. 1-subunit degredation: evidence for multiple subunit specific rates. Am. J. Physiol. 264:C583-C590.
40. Shanbaky, N.M., and T.A. Pressley. 1995. Transfection of Na,K-ATPase α-subunit: regulation of enzyme abundance. Biochem. Cell Biol. 73:261-281.
41. Ewart, H.S., and A. Klip. 1995. Hormonal regulation of the Na,K-ATPase: mechanisms underlying rapid and sustained changes in pump activity. Am. J. Physiol.:269:C295-C311.
42. Sakuma, T., H.G. Folkesson, S. Suzuki, G. Okaniwa, S. Fujimura, and M.A. Matthay. 1997. β-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs. Am. J. Resp. Crit. Care Med. 155:506-512.
43. Saumon, G., G. Basset, F. Bouchonnet, and C. Crone. 1987. cAMP and β-adrenergic stimulation of rat alveolar epithelium. Effects on fluid absorption and paracellular permeability. Pflugers Arch. 410:464-470.
44. Lemas, M.V., M. Hamrick, K. Takeyasu, and D.M. Fambrough. 1994. 26 amino acids of an extracellular domain of the Na,K-ATPase a-subunit are sufficient for assembly with the Na,K-ATPase β-subunit. J. Biol. Chem. 269:8255-8259.
45. Munzer, J.S., S.E. Daly, E.A. Jewell-Motz, J.B. Lingrel, and R. Blostein. 1994. Tissue and isoform specific kinetic behavior of the Na,K-ATPase. J. Biol. Chem. 269:16668-16676.
46. Price, E.M., D.A. Rice, and J.B. Lingrel. 1990. Structure function studies of Na,K-ATPase. J. Biol. Chem. 265:6638-6641.
47. DeTomaso, A.W., G. Blanco, and R.W. Mercer. 1994. The α and βsubunits of the Na,K-ATPase can assemble at the plasma membrane into functional enzyme. J. Cell Biol. 127:55-69.
48. 3 isoforms expressed in HeLa cells. J. Biol. Chem. 266:16925-16930.
49. Blanco, G., J.C. Koster, and R.W. Mercer. 1994. The α subunit of the Na,K-ATPase specifically and stably associates into oligomers. Proc. Natl. Acad. Sci. USA. 91:8542-8546.
50. Brody, S.L., and R.G. Crystal. 1994. Adenovirus-mediated in vivo gene transfer. Ann. NY Acad. Sci. 716:90-101.
51. Amin, R., R. Wilmot, Y. Schwartz, B. Trapnell, and J. Stark. 1995. Replication deficient adenovirus induces expression of interieukin-8 by airway epithelial cells in vitro. Hum. Gene Ther. 6:145-153.
52. Pilewski, J.M., D.J. Sott, J.M. Wilson, and S.M. Albelda. 1995. ICAM-1 expression on bronchial epithelium after recombinant adenovirus infection. Am. J. Respir. Cell Mol. Biol 12:142-148.
53. Wilson, J.M. 1996. Adenoviruses as gene-delivery vehicles. N. Eng. J. Med. 334:1185-1188.
54. Crystal, R.G., N.G. McElvaney, M.A. Rosenfeld, C. Chu, A. Mastrangeli, J.G. Hay, S.L. Brody, H.A. Jaffe, N.T. Eissa, and C. Danel. 1994. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat. Genet. 8:42-51.
55. Berencsi, K., A. Uri, T. Valyi-Nagy, I. Valyi-Nagy, B. Meignier, F.V. Peretz, R.F. Rando, S.A. Plotkin, and E. Gönczöl. 1994. Early region 3-replacement adenovirus recombinants are less pathogenic in cotton rats and mice than early region 3-deleted viruses. Lab. Invest. 71:350-358.
56. Yang, Y., L. Qin, H.C.J. Ertl, and J. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004-2015.