The expanding role of PTEN in neoplasia: A molecule for all seasons? Commentary re: M. A. Davies, et al., Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells. Clin. Cancer Res., 8: 1904-1914, 2002

Clinical Cancer Research

Volumn 8, Issue 6, 2002, Pages 1695-1698

  Fernandez, Magali ^a   Eng, Charis ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53;

APOPTOSIS; CANCER GROWTH; CELL CYCLE; CELL MIGRATION; CHROMOSOME 10Q; COWDEN SYNDROME; DEVELOPMENTAL DISORDER; ENZYME SPECIFICITY; FAMILIAL CANCER; GENE THERAPY; GENETIC SUSCEPTIBILITY; HUMAN; MUTATION; NEOPLASM; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW;

ANIMALS; CELL CYCLE; CELL DIVISION; GENE THERAPY; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MICE; NEOPLASMS; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS;

EID: 0036281498     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells
2. Localization of the gene for Cowden disease to 10q22-23
3. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer
4. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
5. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor B
6. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
7. Mutation spectrum and genotypephenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
8. PTEN mutation spectrum and genotypephenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
9. Association of germline mutation in the PTEN tumour suppressor gene and a subset of Proteus sand Proteus-like syndromes
10. Will the real Cowden syndrome please stand up: Revised diagnostic criteria
11. Bannayan-Riley-Ruvalcaba syndrome
12. Proteus syndrome: Diagnostic criteria, differential diagnosis and patient evaluation
13. A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation and features of VATER association
14. Macrocephaly, macrosomia and autistic behavior due to a de novo PTEN germline mutation
15. Protean PTEN: Form and function
16. Mutations of the human PTEN gene
17. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
18. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
19. Over-representation of PPARγ sequence variants in sporadic cases of glioblastoma multiforme: Preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population
20. Molecular identification of latent precancers in histologically normal endometrium
21. Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
22. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors
23. Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells
24. PTEN expression and clinico-pathologic features in a population-based series of primary cutaneous melanoma
25. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
26. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
27. Analysis of PTEN and the 10q23 region in primary prostate carcinomas
28. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
29. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
30. Localization of metastasis suppressor gene(s) for rat prostatic cancer to the long arm of human chromosome 10
31. Growth suppression of glioma cells by PTEN requires a functional catalytic domain
32. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells
33. PTEN suppresses breast cancer cell growth by phosphatase function-dependent G1 arrest followed by apoptosis
34. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis
35. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN
36. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger phosphoinositol 3,4,5-triphosphate
37. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
38. PTEN is essential for embryonic development and tumour suppression
39. PTEN coordinates G1 arrest by down regulating cyclin D1 via its protein phosphatase activity and up regulating p27 via its lipid phosphatase activity
40. Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo