Over-representation of PPARγ sequence variants in sporadic cases of glioblastoma multiforme: Preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population

Journal of Medical Genetics

Volumn 37, Issue 6, 2000, Pages 410-414

  Zhou, Xiao Ping ^a   Black, Peter McL ^b   Yates, Allan J ^a   Eng, Charis ^a   Smith, Wendy M ^a   Gimm, Oliver ^a   Mueller, Elisabetta ^b   Gao, Xin ^a   Sarraf, Pasha ^b   Prior, Thomas W ^a   Plass, Christoph ^a   Von Deimling, Andreas ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Peroxisome proliferator activated receptors; Sequence variants; Tumour suppressor

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; CELL RECEPTOR; ISOPROTEIN; TRANSCRIPTION FACTOR;

ALLELE; ARTICLE; CLINICAL ARTICLE; CODON; CONTROLLED STUDY; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GLIOBLASTOMA; HETEROZYGOSITY; HUMAN; PRIORITY JOURNAL; BRAIN TUMOR; CHI SQUARE DISTRIBUTION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; GERMANY; HETEROZYGOTE; MUTATION; NUCLEOTIDE SEQUENCE; PENETRANCE; RISK; STATISTICAL ANALYSIS; UNITED STATES;

ALLELES; BRAIN NEOPLASMS; CHI-SQUARE DISTRIBUTION; CODON; DNA MUTATIONAL ANALYSIS; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; GERMANY; GLIOBLASTOMA; HETEROZYGOTE; HUMANS; LINKAGE DISEQUILIBRIUM; MATCHED-PAIR ANALYSIS; ODDS RATIO; PENETRANCE; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; UNITED STATES; VARIATION (GENETICS);

EID: 0033625429     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARg2, a lipid activated transcription factor. Cell 1994;79:1147-56.
2. Spiegelman BM. PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 1998;47:507-14.
3. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor g and promotes adipocyte differentiation. Cell 1995;83:813-19.
4. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 1995;83:803-12.
5. Sarraf P, Mueller E, Jones D, et al. Differentiation and reversal of malignant changes in colon cancer through PPAR-γ. Nat Med 1998;4:1046-52.
6. Mueller E, Sarraf P, Tontonoz P, et al. Terminal differentiation of human breast cancer through PPARγ. Mol Cell 1998;1:465-70.
7. Brockman JA, Gupta RA, Dubois RN. Activation of PPAR-gamma leads to inhibition of anchorage-independence growth of human colorectal cancer cells. Gastroenterology 1998;115:1049-55.
8. Dubois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA. The nuclear eicosanoid receptor, PPARg, is aberrantly expressed in colonic cancers. Carcinogenesis 1998;19:49-53.
9. Levebvre AM, Chen I, Desreumaux P, et al. Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCmin/+ mice. Nat Med 1998;4:1053-6.
10. Saez E, Tontonoz P, Nelson MC, et al. Activators of the nuclear receptor PPAR-γ enhance colon polyp formation. Nat Med 1998;4:1058-61.
11. Sarraf P, Mueller E, Smith WM, et al. Loss of function mutations in PPARγ associated with human colorectal cancer. Mol Cell 1999;3:799-804.
12. Cullingford TE, Bhakoo K, Peuchen S, Dolphin CT, Patel R, Clark JB. Distribution of mRNAs encoding the peroxisome proliferator-activated receptor alpha, beta and gamma and the retinoid X receptor alpha, beta and gamma in rat central nervous system. J Neurochem 1998;70:1366-75.
13. Elbrecht A, Chen Y, Cullinan CA, et al. Molecular cloning, expression and characterisation of human peroxisome proliferator-activated receptors gamma 1 and gamma 2. Biochem Biophys Res Commun 1996;16:431-7.
14. Inskip PD, Linet MS, Heineman EF. Etiology of brain tumors in adults. Epidemiol Rev 1995;17:382-414.
15. Mathew CGP, Smith BA, Thorp K, et al. Deletion of genes on chromosome 1 in endocrine neoplasia. Nature 1987;328:524-6.
16. Yen CJ, Beamer BA, Negri C, et al. Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPARg) gene in diabetic Caucasians: identification of a Pro12Ala PPARg2 missense mutation. Biochem Biophys Res Commun 1997;241:270-4.
17. Liaw D, Marsh DJ, Li J, et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 1997;16:64-7.
18. Dahia PLM, Aguiar RCT, Alberta J, et al. PTEN is inversely correlated with the cell survival factor PKB/Akt and is inactivated by diverse mechanisms in haematologic malignancies. Hum Mol Genet 1999;8:185-93.
19. Gimm O, Neuberg DS, Marsh DJ, et al. Over-representation of a germline RET sequence variant in patients with sporadic medullary thyroid carcinoma and somatic RET codon 918 mutation. Oncogens 1999;18:1369-70.
20. Meirhaeghe A, Fajas L, Helbecque N, et al. A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans. Hum Mol Genet 1998;7:435-40.
21. de la Chapelle A, Wright FA. Linkage disequilibrium mapping in isolated populations: the example of Finland revisited. Proc Natl Acad Sci USA 1998;95:12416-23.
22. Deeb SS, Fajas L, Nemoto M, et al. A Pro12Ala substitution in PPARg2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998;20:284-7.
23. Kaplan S, Novikov I, Modan B. Nutritional factors in the etiology of brain tumors: potential role of nitrosamines, fat and cholesterol. Am J Epidemiol 1997;146:832-41.