A20 inhibits NF-κB activation downstream of multiple Map3 kinases and interacts with the IκB signalosome

Cytokine

Volumn 15, Issue 6, 2001, Pages 282-298

  Zetoune, Firas S ^a   Murthy, Anita R ^a   Shao, Zhihong ^a   Hlaing, Tom ^a   Zeidler, Michael G ^a   Li, Yong ^a   Vincenz, Claudius ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

A20; I B signalosome; MAP3 kinases; NF B inhibition; Nuclear translocation

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PROTEIN A20; SYNAPTOTAGMIN; TAX PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; DNA BINDING; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

EID: 0035929684     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2001.0921     Document Type: Article

References (63)

1. Biology of disease
2. Tumor necrosis factor receptor and Fas signaling mechanisms
3. Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin
4. The A20 Zinc finger protein protects cells from tumor necrosis factor cytotoxicity
5. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation
6. Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors
7. CD40 induces resistance to TNF-mediated apoptosis in a fibroblast cell line
8. A20 zinc finger protein inhibits TNF and IL-1 signaling
9. A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism
10. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
11. Isolation and characterization of two novel A20-like proteins
12. Life-death balance within the cell
13. A20 inhibits NF-kappaB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis
14. A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets
15. Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells
16. TNF receptor associated factors in cytokine signaling
17. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
18. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
19. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation
20. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
21. Embryonic lethality, liver degeneration and impaired NF-kappa B activation in IKK-beta-deficient mice
22. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
23. Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase
24. Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice
25. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation
26. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKγ) upon receptor stimulation
27. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
28. Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression
29. Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines
30. The SRE: A growth factor responsive transcriptional regulator
31. Signaling by proinflammatory cytokines: Oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
32. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
33. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases
34. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
35. HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene
36. HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor
37. Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-1 tax gene product
38. The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta
39. IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein
40. Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes
41. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein
42. Nuclear factor kB-independent cytoprotective pathways originating at tumor necrosis factor receptor-associated factor 2
43. The yopJ locus is required for Yersinia-mediated inhibition of NF-kappaB activation and cytokine expression: yopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity
44. Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector
45. 14-3-3 Proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules
46. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
47. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6
48. Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
49. ASK1 is essential for JNK/SAPK activation by TRAF2
50. Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
51. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN
52. Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: Additional defect in neurulation
53. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription
54. Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit
55. Activation of NF-kappa B in vivo is regulated by multiple phosphorylations
56. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit
57. Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529
58. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
59. IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain
60. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
61. A novel RING finger protein interacts with the cytoplasmic domain of CD40
62. Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers
63. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei