Mutations in DNA replication genes reduce yeast life span

Molecular and Cellular Biology

Volumn 22, Issue 12, 2002, Pages 4136-4146

  Mays Hoopes, Laura L ^a   Budd, Martin ^a   Choe, Wonchae ^a   Weitao, Tao ^a   Campbell, Judith L ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA2 PROTEIN; GENE PRODUCT; HELICASE; UNCLASSIFIED DRUG;

AGING; ARTICLE; BLOOM SYNDROME; CANCER SUSCEPTIBILITY; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENE REPLICATION; GENETIC CODE; GENETIC STABILITY; LIFESPAN; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; ROTHMUND THOMSON SYNDROME; SENESCENCE; STRESS; VERNER MORRISON SYNDROME; YEAST;

EID: 0036261565     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.12.4136-4146.2002     Document Type: Article

References (100)

1. Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein
2. Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae
3. A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae
4. Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP
5. RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes
6. Werner syndrome protein: Biochemical properties and functional interaction
7. A new yeast gene required for DNA replication encodes a protein with homology to DNA helicases
8. The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in DSB and postreplication repair pathways
9. A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function
10. DNA2 encodes a DNA helicase essential for replication of eukaryotic chromosomes
11. DNA polymerase I is required for DNA replication but not for repair in Saccharomyces cerevisiae
12. Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication
13. Elimination of replication block protein Fob1 extends the life span of yeast mother cells
14. Role of the putative zinc finger domain of Saccharomyces cerevisiae DNA polymerase ε in DNA replication and the S/M checkpoint pathway
15. A role for the replication proteins PCNA, RF-C, polymerase ε and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae
16. DNA helicases in inherited human disorders
17. The Bloom's syndrome gene product is homologous to RecQ helicases
18. Function of RecQ family helicases: Possible involvement of Bloom's and Werner's syndrome gene products in guarding genome integrity during DNA replication
19. Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S Phase
20. Dna2 mutants reveal interactions with DNA polymerase alpha and Ctf4, a Po1 alpha accessory factor, and show that full DNA2 helicase activity is not essential for growth
21. The yeast Sgslp helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
22. The yeast type I topoisomerase TOP3 interacts with SGS1, a DNA helicase
23. Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases
24. A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA
25. Genetic pathways that regulate ageing in model organisms
26. A retarded rate of DNA chain growth in Bloom's syndrome
27. Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae
28. The limited in vitro lifespan of human diploid cell strains
29. Bloom's syndrome gene suppresses premature aging caused by Sgs1 deficiency in yeast
30. Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases
31. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
32. The impact of lagging strand replication mutations on the stability of CAG repeat tracts in yeast
33. An experimental system for the molecular analysis of the aging process: The budding yeast Saccharomyces cerevisiae
34. Molecular mechanisms of yeast longevity
35. Replication control and cellular life span
36. Epigenetic stratification: The role of individual change in the biological aging process
37. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
38. + reveal that Dna2 plays an essential role in Okazaki fragment metabolism
39. The Bloom's syndrome gene product promotes branch migration of Holliday junctions
40. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae
41. Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae
42. Effect of replicative age on transcriptional silencing near telomeres in Saccharomyces cerevisiae
43. Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
44. Mutations in RECOL4 cause a subset of cases of Rothmund-Thomson syndrome
45. Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: Requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I
46. Identification of a site required for DNA replication fork blocking activity in the rRNA gene cluster in Saccharomyces cerevisiae
47. Stable DNA replication: Interplay between DNA replication, homologous recombination, and transcription
48. CTF4 (CHL15) mutants exhibit defective DNA metabolism in the yeast Saccharomyces cerevisiae
49. Isolation of yeast DNA replication mutants using permeabilized cells
50. Recombination repair of DNA damage in Escherichia coli and bacteriophage lambda
51. Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis
52. Requirement of yeast SGS1 and SRS2 genes for replication and transcription
53. The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication
54. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
55. Enhanced gluconeogenesis and increased energy storage as hallmarks of aging in Saccharomyces cerevisiae
56. An abnormal profile of DNA replication intermediates in Bloom's syndrome
57. The DNA replication checkpoint response stabilizes stalled replication forks
58. The function of DNA polymerase α at telomeric G tails is important for telomere homeostasis
59. Rescue of stalled replication forks by RecG: Simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation
60. Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled
61. The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination
62. DNA double-strand breaks caused by replication arrest
63. Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase α, acts in DNA metabolism in vivo
64. Protein affinity chromatography with purified yeast DNA polymerase alpha detects proteins that bind to DNA polymerase
65. Role of DNA replication in the repression of silent mating type loci in yeast
66. Life span of individual yeast cells
67. Pedigree analysts of plasmid segregation in yeast
68. SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homologous recombination
69. Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27
70. Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae
71. Constancy of ribosomal RNA genes during aging of mouse heart cells and during serial passage of WI-38 cells
72. Impaired S phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
73. RuvAB acts at arrested replication forks
74. Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
75. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex
76. Aging in Saccharomyces cerevisiae
77. Extrachromosomal rDNA circles - A cause of aging in yeast
78. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutations
79. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae
80. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae
81. An unusual form of transcriptional silencing in yeast ribosomal DNA
82. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity
83. Altered frequency of initiation sites of DNA replication in Werner's syndrome cells
84. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs
85. Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases
86. Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
87. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product
88. Increased dosage of a SIR2 gene extends lifespan in Caenorhabditis elegans
89. Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus
90. Yeast RNA polymerase I enhancer is dispensable for transcription of the chromosomal rRNA gene and cell growth, and its apparent transcription enhancement from ectopic promoters requires Fob1 protein
91. Postreplication repair in ultraviolet-irradiated human fibroblasts: Formation and repair of DNA double-strand breaks
92. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae
93. Sgs1: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation
94. Sister chromatid exchanges induced in Chinese hamster cells by UV irradiation of different stages of the cell cycle: The necessity for cells to pass through S
95. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases
96. Positional cloning of the Werner's syndrome gene
97. PCNA connects DNA replication to epigenetic inheritance in yeast
98. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism