Functions of RecQ family helicases: Possible involvement of Bloom's and Werner's syndrome gene products in guarding genome integrity during DNA replication

Journal of Biochemistry

Volumn 129, Issue 4, 2001, Pages 501-507

  Enomoto, T ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Bloom's syndrome; DNA topoisomerase III; RecQ helicase; Sgs1; Werner' syndrome

Indexed keywords

DNA TOPOISOMERASE; GENE PRODUCT; HELICASE;

BLOOM SYNDROME; CONTROLLED STUDY; DNA REPLICATION; ESCHERICHIA COLI; GENOME; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FAMILY; REVIEW; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; WERNER SYNDROME;

ESCHERICHIA COLI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0035050472     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a002883     Document Type: Review

References (63)

1. Bloom's syndrome: A mendelian prototype of somatic mutational disease
2. The Bloom's syndrome gene product is homologous to RecQ helicases
3. Positional cloning of the Werner's syndrome gene
4. Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process
5. Cellular aging-clonal senescence
6. A retarded rate of DNA chain growth in Bloom's syndrome
7. An abnormal profile of DNA replication intermediates in Bloom's syndrome
8. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
9. Altered frequency of initiation sites of DNA replication in Werner's syndrome cells
10. Sgs1: A eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation
11. Sgs1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae
12. Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene
13. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases
14. Sgs1 helicase activity is required for mitotic but apparently not for meiotic function
15. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants
16. Bipartite Structure of the SGS1 DNA helicase in Saccharomyces cerevisiae
17. Isolation and genetic characterization of a thymineless-death resistant mutant of Escherichia coli K12: Identification of a new mutation (recQ1) that blocks the RecF recombination pathway
18. Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli RecQ helicase and localization of the gene at chromosome 12p12
19. Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ
20. Alteration of a DNA-dependent ATPase activity in xeroderma pigmentosum complementation group C cells
21. Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes
22. Cloning of two new human helicase genes of the RecQ family: Biological significance of multiple species in higher eukaryotes
23. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome
24. +, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
25. Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerase 3alpha and 3beta
26. recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli
27. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic reverse gyrase
28. Human homologues of yeast helicase
29. The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs
30. Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae
31. Identification of a site required for DNA fork blocking activity in the rRNA gene cluster in Saccharomyces cerevisiae
32. Interaction between yeast Sgs1 helicase and DNA topoisomerase III
33. The role of DNA topoisomerases in recombination and genome stability; a double-edged sword?
34. RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: A conserved mechanism for control of DNA recombination
35. Decatenating activity of Escherichia coli DNA gyrase and topoisomerase I and III during oriC and pBR322 DNA replication
36. Involvement of SGS1 in DNA Damage-induced heteroallelic recombination that requires RAD52
37. Homologous recombination is responsible for the cell death in the absence of the Sgs1 and Srs2 helicases
38. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
39. Cell cycle regulation of the endogenous wild type Bloom's syndrome helicase
40. Nuclear structure in normal and Bloom syndrome cells
41. The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication
42. The Bloom's syndrome gene product is a 3′-5′ DNA helicase
43. Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity
44. The Bloom's syndrome helicase unwinds G4DNA
45. The Bloom's syndrome gene product promotes branch migration of Holliday junctions
46. The Bloom's syndrome gene product interacts with topoisomerase III
47. Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene
48. Possible association of BLM in decreasing DNA double strand breaks during DNA replication
49. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism
50. RuvAB acts at arrested replication forks
51. Increased amounts of hybrid (heavy/heavy) DNA in Bloom's syndrome fibroblasts
52. Werner syndrome protein: Biochemical properties and functional interactions
53. Human Werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n
54. Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
55. Functional and physical interaction between WRN helicase and human replication protein A
56. Werner protein recruits DNA polymerase δ to the nucleolus
57. Functional interaction between the Werner syndrome protein and DNA polymerase δ
58. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I
59. Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein: Ku70/80 complex
60. Physical and functional interaction between p53 and the Werner's syndrome protein
61. p53-mediated apoptosis is attenuated in Werner syndrome cells
62. Covalent modification of the Werner's syndrome gene product with ubiquitin-related protein, SUMO-1
63. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures