Tyrosin phosphorylation of p120ctn in v-Src transfected L cells depends on its association with E-cadherin and reduces adhesion activity

Journal of Cell Science

Volumn 114, Issue 3, 2001, Pages 503-512

  Ozawa, M ^a   Ohkudo, T ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Cadherin; Catenin; P120; Phosphorylation; Regulation

Indexed keywords

ALPHA CATENIN; AMINO ACID; CADHERIN; CALCIUM ION; MEMBRANE PROTEIN; PHENYLALANINE; PROTEIN P120; SERINE; THREONINE; TYROSINE; UVOMORULIN; CADHERIN ASSOCIATED SRC SUBSTRATE P120; CADHERIN-ASSOCIATED SRC SUBSTRATE P120; CELL ADHESION MOLECULE; PHOSPHOPROTEIN; PRIMER DNA; PROTEIN KINASE P60;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL AGGREGATION; CELL MEMBRANE; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; CHIMERA; COMPLEX FORMATION; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENETIC TRANSFECTION; L CELL; MOUSE; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PROTEIN BINDING; SERODIAGNOSIS;

AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; CADHERINS; CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE; DNA PRIMERS; MICE; ONCOGENE PROTEIN PP60(V-SRC); PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; SERINE; THREONINE; TYROSINE;

EID: 0034745687     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Assembly of the cadherin-catenin complex in vitro with recombinant proteins
2. The E-cadherin complex contains the src substratep120
3. ctn acts as an inhibitory regulator of cadherin function in colon carcinoma cells
4. Regulated binding of PTP1B-like phosphatase to N-cadherin: Control of cadherin-mediated adhesion by dephosphorylation of β-catenin
5. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene
6. Tyrosine phosphorylation and Src family kinases control keratinocyte cell-cell adhesion
7. Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation
8. cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or α-catenin
9. src transformation-associated substrate
10. Cadherins
11. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
12. v-src causestyrosine phosphorylation and inactivation of N-cadherin-catenin cell adhesion system
13. Dynamics of cadherin/catenin complex formation: Novel protein interactions and pathways of complex assembly
14. E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton
15. A simple and rapid method for generating a deletion by PCR
16. Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding α catenin and actin filaments
17. src substrate upon epidermal growth factor and platelet-derived growth factor stimulation and in polyomavirus middle-T-antigen-transformed cells
18. From cadherines to catenins: Cytoplasmic protein interactions and regulation of cell adhesion
19. Tyrosine phosphorylation regulatesthe adhesion of ras-transformed breast epithelia
20. Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells
21. Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts
22. Characterization of the interactions of α-catenin with α-actinin and β-catenin/plakoglobin
23. Efficient selection for high-expression transfectants with a novel eukaryotic vector
24. Localization of specificity determining sites in cadherin cell adhesion molecules
25. Identification of the domain of α-catenin involved in its association with β-catenin and plakoglobin
26. ctn binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity
27. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species
28. 2+ binding site of uvomorulin abolish the adhesive function
29. Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule
30. Molecular organization of the uvomorulin-catenin complex
31. Identification of the region of α-catenin that plays an essential role in cadherin-mediated cell adhesion
32. Altered cell adhesion activity by pervanadate due to the dissociation of α-catenin from the E-cadherin-catenin complex
33. The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity
34. Regulation of complexed and free catenin pools by distinct mechanisms. Differential effects of Wnt-1 and v-Src
35. Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of avian cellular src gene
36. v-src, is related to cadherin-binding factors, β-catenin, plakoglobin and armadillo
37. cas associates with E-cadherin complexes
38. cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts
39. α1 (E)-Catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex
40. Involvement of tyrosine kinase Fer in cell adhesion
41. Regulation of E-cadherin/Catenin association by tyrosine phosphorylation
42. Inhibition of β-catenin-mediated transactivation by cadherin derivatives
43. Tyrosine phosphorylation of β-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells
44. Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes
45. p120, a p120-related protein (p100), and the cahderin/catenin complex
46. V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and β catenin is not required for the shift
47. E-cadherin function as a cis-dimer at the cell-cell adhesive interface in vivo
48. Cadherin cell adhesion receptors as a morphogenetic regulator
49. ctn from E-cadherin disrupts strong adhesion
50. Identification of a putative cell adhesion domain of uvomorulin
51. α-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells
52. Vinculin is part of the cadherin-catenin junctional complex: Complex formation between α-catenin and vinculin
53. ctn