Cytotoxic immune response blunts long-term transgene expression after efficient retroviral-mediated hepatic gene transfer in rat

Molecular Therapy

Volumn 5, Issue 4, 2002, Pages 388-396

  Aubert, Dominique ^a   Ménoret, Séverine ^b   Chiari, Estelle ^a   Pichard, Virginie ^a   Durand, Sophie ^a   Tesson, Laurent ^b   Moullier, Philippe ^a   Anegon, Ignacio ^b   Ferry, Nicolas ^a  

^a INSERM   (France)

^b HÔTEL DIEU   (France)

Author keywords

Bilirubin; Bilirubin glucuronosyl transferase; Gene transfer; Gunn rat; Immune response; Liver; Retroviral vector; Transgenic rats; galactosidase

Indexed keywords

BETA GALACTOSIDASE; CD8 ANTIGEN; COMPLEMENTARY DNA; GENE PRODUCT; GLUCURONOSYLTRANSFERASE; PROTEIN ANTIBODY; RETROVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; EXPRESSION VECTOR; GENE EXPRESSION; GENETIC TRANSDUCTION; HEPATITIS; IMMUNE RESPONSE; JAUNDICE; LIVER CELL; LIVER REGENERATION; LIVER RESECTION; LYMPHOCYTE DEPLETION; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; RAT; SPLEEN; TISSUE SECTION; TRANSGENE; TRANSGENIC ANIMAL; VIRAL GENE DELIVERY SYSTEM; VIRUS GENOME;

ANIMALIA; RATTUS NORVEGICUS; UNIDENTIFIED RETROVIRUS; VECTORS;

EID: 0036230068     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0561     Document Type: Article

References (48)

1. Liver-directed gene transfer vectors
2. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
3. In vivo hepatic gene therapy-complete albeit transient correction of Factor IX deficiency in hemophilia B dogs
4. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses
5. Complete correction of hyperbilirubinemia in the Gunn rat model of Crigler-Najjar syndrome type I following transient in vivo adenovirus-mediated expression of human bilirubin UDP-glucuronosyl-transferase
6. Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I
7. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
8. Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver
9. An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene
10. High doses of a helper-dependent adenoviral vector yield supraphysiological levels of (1-antitrypsin with negligible toxicity
11. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors
12. Persistent, therapeutically relevant levels of human granulocyte colony-stimulating factor in mice after systemic delivery of adeno-associated virus vectors
13. CMV-β-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 (promoter and results in therapeutic levels of human factor X in mice
14. Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA
15. Sustained correction of bleeding disorder in hemophilia B mice by gene therapy
16. Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors
17. Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and D
18. Role of vector in activation of T cell subsets in immune responses against the secreted transgene product factor IX
19. Factors influencing cross-presentation of non-self antigens expressed from recombinant adeno-associated virus vectors
20. A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus
21. Transduction of liver cells by lentiviral vectors: Analysis in living animals by fluorescence imaging
22. Highly efficient retrovirus-mediated gene transfer into rat hepatocytes in vivo
23. Liver-directed gene therapy-quantitative evaluation of promoter elements by using in vivo retroviral transduction
24. Therapeutic levels of human protein C in rats after retroviral vector-mediated hepatic gene therapy
25. In vivo hepatocyte retrovirus-mediated gene transfer through the rat biliary tract
26. In vivo retrovirus-mediated gene transfer to the liver of dogs results in transient expression and induction of a cytotoxic immune response
27. Direct injection of a recombinant retroviral vector induces human immunodeficiency virus-specific immune responses in mice and nonhuman primates
28. Characterization of CD8+ cytotoxic T-lymphocyte responses after genetic immunization with retrovirus vectors expressing different forms of the hepatitis B virus core and e antigens
29. Liver regeneration after partial hepatectomy in rats with defective bilirubin conjugation or biliary excretion
30. In vivo gene therapy of hemophilia-B-sustained partial correction in Factor-IX-deficient dogs
31. Therapeutic levels of functional human factor X in rats after retroviral-mediated hepatic gene therapy
32. Adenovirus-mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo
33. Liver-directed gene therapy: A retroviral vector with a complete LTR and the ApoE enhancer-α(1)-antitrypsin promoter dramatically increases expression of human α(1)-antitrypsin in vivo
34. Long-term reduction of serum bilirubin levels in Gunn rats by retroviral gene transfer in vivo
35. Antigen presentation in retroviral vector-mediated gene transfer in vivo
36. Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers
37. 3H
38. Delivery of a retroviral vector expressing human β-glucuronidase to the liver and spleen decreases lysosomal storage in mucopolysaccharidosis VII mice
39. Dendritic cells acquire antigen from apoptotic cells and induce class I- restricted CTLs
40. Successful interference with cellular immune response to immunogenic proteins encoded by recombinant viral vectors
41. MHC-I-restricted presentation of HIV-1 virion antigens without viral replication
42. Break of T cell ignorance to a viral antigen in the liver induces hepatitis
43. In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat
44. Transgenesis in rats: Technical aspects and models
45. Protection against hyperacute xenograft rejection of transgenic rat hearts expressing human decay accelerating factor (DAF) transplanted into primates
46. The human immunodeficiency virus long terminal repeat is preferentially expressed in Langerhans cells in transgenic mice
47. Experimental pathology of the liver I. Restoration of the liver of the white rat following partial surgical removal
48. High-titer packaging cells producing recombinant retroviruses resistant to human serum