메뉴 건너뛰기




Volumn 101, Issue 12, 1998, Pages 2831-2841

Therapeutic levels of human protein C in rats after retroviral vector- mediated hepatic gene therapy

Author keywords

Antibody; Gene therapy; Liver; Protein C; Retroviral vector

Indexed keywords

CHROMOGENIC SUBSTRATE; PROTEIN C; VIRUS VECTOR;

EID: 0032525902     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1880     Document Type: Article
Times cited : (20)

References (77)
  • 1
    • 0010548624 scopus 로고
    • Introduction to hemostasis and the vitamin K-dependent coagulation factors
    • Scriver, C.R., A.L. Beaudet, W.S. Sly, and D. Valle, editors. McGraw Hill Inc., New York
    • Reiner, A.P., and E.W. Davie. 1995. Introduction to hemostasis and the vitamin K-dependent coagulation factors. In The Metabolic and Molecular Bases of Inherited Disease. 7th ed. Scriver, C.R., A.L. Beaudet, W.S. Sly, and D. Valle, editors. McGraw Hill Inc., New York. 3181-3221.
    • (1995) The Metabolic and Molecular Bases of Inherited Disease. 7th Ed. , pp. 3181-3221
    • Reiner, A.P.1    Davie, E.W.2
  • 3
    • 0023233223 scopus 로고
    • Absence of thrombosis in subjects with heterozygous protein C deficiency
    • Miletich, J., L. Sherman, and G. Broze. 1987. Absence of thrombosis in subjects with heterozygous protein C deficiency. N. Engl. J. Med. 317:991-996.
    • (1987) N. Engl. J. Med. , vol.317 , pp. 991-996
    • Miletich, J.1    Sherman, L.2    Broze, G.3
  • 4
    • 0029033740 scopus 로고
    • Protein C deficiency in a controlled series of unselected outpatients: An infrequent but clear risk for venous thrombosis (Leiden thrombophilia study)
    • Koster, T., F.R. Rosendaal, E. Briet, J.M. van der Meer, L.P. Colly, P.H. Trienekens, S. Poort, P.H. Reitsma, and J.P. Vanderbroucke. 1995. Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk for venous thrombosis (Leiden thrombophilia study). Blood. 85:2756-2761.
    • (1995) Blood , vol.85 , pp. 2756-2761
    • Koster, T.1    Rosendaal, F.R.2    Briet, E.3    Van Der Meer, J.M.4    Colly, L.P.5    Trienekens, P.H.6    Poort, S.7    Reitsma, P.H.8    Vanderbroucke, J.P.9
  • 8
    • 0021930913 scopus 로고
    • Neonatal purpura fulminans: A genetic disorder related to the absence of protein C in blood
    • Marciniak, E., H.D. Wilson, and R.A. Marlar. 1985. Neonatal purpura fulminans: a genetic disorder related to the absence of protein C in blood. Blood. 65:15-20.
    • (1985) Blood , vol.65 , pp. 15-20
    • Marciniak, E.1    Wilson, H.D.2    Marlar, R.A.3
  • 9
    • 0023858403 scopus 로고
    • Successful treatment of homozygous protein C deficiency by hepatic transplantation
    • Casella, J.F., F.A. Bontempo, H. Markel, J.H. Lewis, B.J. Zitelli, and T.E. Starzl. 1988. Successful treatment of homozygous protein C deficiency by hepatic transplantation. Lancet. i:435-437.
    • (1988) Lancet , vol.1 , pp. 435-437
    • Casella, J.F.1    Bontempo, F.A.2    Markel, H.3    Lewis, J.H.4    Zitelli, B.J.5    Starzl, T.E.6
  • 10
    • 0029968541 scopus 로고    scopus 로고
    • Treatment of homozygous protein C deficiency with subcutaneous protein C concentrate
    • Minford, A.M.B., L.A. Parapia, C. Stainforth, and D. Lee. 1996. Treatment of homozygous protein C deficiency with subcutaneous protein C concentrate. Br. J. Haematol. 93:215-216.
    • (1996) Br. J. Haematol. , vol.93 , pp. 215-216
    • Minford, A.M.B.1    Parapia, L.A.2    Stainforth, C.3    Lee, D.4
  • 12
    • 0030044808 scopus 로고    scopus 로고
    • Purpura fulminans in severe congenital protein C deficiency: Monitoring of treatment with protein C concentrate
    • Muller, F.M., W. Ehrenthal, G. Hafner, and D. Schranz. 1996. Purpura fulminans in severe congenital protein C deficiency: monitoring of treatment with protein C concentrate. Eur. J. Pediatr. 155:20-25.
    • (1996) Eur. J. Pediatr. , vol.155 , pp. 20-25
    • Muller, F.M.1    Ehrenthal, W.2    Hafner, G.3    Schranz, D.4
  • 15
    • 0021086761 scopus 로고
    • Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant
    • Branson, H.E., J. Katz, R. Marble, and J.H. Griffin. 1983. Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant. Lancet. ii:1165-1168.
    • (1983) Lancet , vol.2 , pp. 1165-1168
    • Branson, H.E.1    Katz, J.2    Marble, R.3    Griffin, J.H.4
  • 17
    • 0022656222 scopus 로고
    • Purpura fulminans in a Chinese boy with congenital protein C deficiency
    • Yuen, P., A. Cheung, H.J. Lin, F. Ho, J. Mimuro, N. Yoshida, and N. Aoki. 1986. Purpura fulminans in a Chinese boy with congenital protein C deficiency. Pediatrics. 77:670-676.
    • (1986) Pediatrics , vol.77 , pp. 670-676
    • Yuen, P.1    Cheung, A.2    Lin, H.J.3    Ho, F.4    Mimuro, J.5    Yoshida, N.6    Aoki, N.7
  • 18
    • 0021911725 scopus 로고
    • Coumarin prophylaxis for fulminant purpura syndrome due to homozygous protein C deficiency
    • Garcia-Plaza, I., C. Jimenez-Astorga, D. Borrego, and M.L. Marty. 1985. Coumarin prophylaxis for fulminant purpura syndrome due to homozygous protein C deficiency. Lancet. i:634-635.
    • (1985) Lancet , vol.1 , pp. 634-635
    • Garcia-Plaza, I.1    Jimenez-Astorga, C.2    Borrego, D.3    Marty, M.L.4
  • 19
    • 0026529348 scopus 로고
    • Evaluation of a new protein-C concentrate and comparison of protein-C assays in a child with congenital protein-C deficiency
    • Auberger, K. 1992. Evaluation of a new protein-C concentrate and comparison of protein-C assays in a child with congenital protein-C deficiency. Ann. Hematol. 64:146-151.
    • (1992) Ann. Hematol. , vol.64 , pp. 146-151
    • Auberger, K.1
  • 20
    • 0027302737 scopus 로고
    • Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency
    • Conrad, J., K.A. Bauer, A. Gruber, J.H. Griffin, H.P. Schwartz, M.H. Horellou, M.M. Samama, and R.D. Rosenberg. 1993. Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency. Blood. 82:1159-1164.
    • (1993) Blood , vol.82 , pp. 1159-1164
    • Conrad, J.1    Bauer, K.A.2    Gruber, A.3    Griffin, J.H.4    Schwartz, H.P.5    Horellou, M.H.6    Samama, M.M.7    Rosenberg, R.D.8
  • 21
    • 0028904215 scopus 로고
    • Prospects for gene therapy for haemophilia A and B
    • Brownlee, G.G. 1995. Prospects for gene therapy for haemophilia A and B. Br. Med. Bull. 51:91-105.
    • (1995) Br. Med. Bull. , vol.51 , pp. 91-105
    • Brownlee, G.G.1
  • 22
    • 0029144825 scopus 로고
    • Progress towards gene therapy for the hemophilias
    • Thompson, A.R. 1995. Progress towards gene therapy for the hemophilias. Thromb. Hemostasis. 74:45-51.
    • (1995) Thromb. Hemostasis , vol.74 , pp. 45-51
    • Thompson, A.R.1
  • 23
  • 24
    • 2442736614 scopus 로고    scopus 로고
    • Gene delivery for systemic expression
    • K.L. March, editor. Kluwar Academic Publishers, Norwell, MA
    • Ponder, K.P. 1997. Gene delivery for systemic expression. In Gene Therapy in the Cardiovascular System. K.L. March, editor. Kluwar Academic Publishers, Norwell, MA. 395-432.
    • (1997) Gene Therapy in the Cardiovascular System , pp. 395-432
    • Ponder, K.P.1
  • 27
    • 0030069229 scopus 로고    scopus 로고
    • High-level tissue-specific expression of functional human factor VIII in mice
    • Connelly, S., J.M. Gardner, A. McClelland, and M. Kaleko. 1996. High-level tissue-specific expression of functional human factor VIII in mice. Hum. Gene Ther. 7:183-195.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 183-195
    • Connelly, S.1    Gardner, J.M.2    McClelland, A.3    Kaleko, M.4
  • 28
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigens allows for long-term expression
    • Dai, Y., E.M. Schwartz, D. Gu, W.-W. Zhang, N. Sarvetnick, and I.M. Verma. 1995. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA. 92:1401-1405.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1401-1405
    • Dai, Y.1    Schwartz, E.M.2    Gu, D.3    Zhang, W.-W.4    Sarvetnick, N.5    Verma, I.M.6
  • 31
    • 0029916598 scopus 로고    scopus 로고
    • Successful expression of human factor IX following repeat administration of an adenoviral vector in mice
    • Walter, J., Q. You, J.N. Hagstrom, M. Sands, and K.A. High. 1996. Successful expression of human factor IX following repeat administration of an adenoviral vector in mice. Proc. Natl. Acad. Sci. USA. 93:3056-3061.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3056-3061
    • Walter, J.1    You, Q.2    Hagstrom, J.N.3    Sands, M.4    High, K.A.5
  • 32
    • 0028223310 scopus 로고
    • Gene transfer in vivo: Sustained expression of genes introduced into the liver by receptor-targeted uptake
    • Perales, J.C., T. Ferkol, H. Beegen, O.D. Ratnoff, and R.W. Hanson. 1994. Gene transfer in vivo: sustained expression of genes introduced into the liver by receptor-targeted uptake. Proc. Natl. Acad. Sci. USA. 91:4086-4090.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4086-4090
    • Perales, J.C.1    Ferkol, T.2    Beegen, H.3    Ratnoff, O.D.4    Hanson, R.W.5
  • 33
    • 0030795619 scopus 로고    scopus 로고
    • Persistent systemic production of human Factor IX in mice by skeletal myoblast-mediated gene transfer: Feasibility of repeat application to obtain therapeutic levels
    • Wang, J.-M., H. Zheng, M. Blaivas, and K. Kurachi. 1997. Persistent systemic production of human Factor IX in mice by skeletal myoblast-mediated gene transfer: feasibility of repeat application to obtain therapeutic levels Blood. 90:1075-1082.
    • (1997) Blood , vol.90 , pp. 1075-1082
    • Wang, J.-M.1    Zheng, H.2    Blaivas, M.3    Kurachi, K.4
  • 35
    • 0026486612 scopus 로고
    • Gene therapy via primary myoblasts: Long-term expression of factor IX protein following transplantation in vivo
    • Dai, Y., M. Roman, R.K. Naviaux, and I.M. Verma. 1992. Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo. Proc. Natl. Acad. Sci. USA. 89:10892-10895.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10892-10895
    • Dai, Y.1    Roman, M.2    Naviaux, R.K.3    Verma, I.M.4
  • 36
    • 0031055741 scopus 로고    scopus 로고
    • Therapeutic levels of functional human factor X in rats after retroviral-mediated hepatic gene therapy
    • Le, M.T., T. Okuyama, S.-R. Cai, S.C. Kennedy, W. Bowling, M.W. Flye, and K.P. Ponder. 1997. Therapeutic levels of functional human factor X in rats after retroviral-mediated hepatic gene therapy. Blood. 89:1254-1259.
    • (1997) Blood , vol.89 , pp. 1254-1259
    • Le, M.T.1    Okuyama, T.2    Cai, S.-R.3    Kennedy, S.C.4    Bowling, W.5    Flye, M.W.6    Ponder, K.P.7
  • 37
    • 0030902985 scopus 로고    scopus 로고
    • Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus
    • Herzog, R.W., J.N. Hagstrom, S.H. Kung, S.J. Tai, J.M. Wilson, K.J. Fisher, and K.A. High. 1997. Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc. Natl. Acad. Sci. USA. 94:5804-5809.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5804-5809
    • Herzog, R.W.1    Hagstrom, J.N.2    Kung, S.H.3    Tai, S.J.4    Wilson, J.M.5    Fisher, K.J.6    High, K.A.7
  • 39
    • 0021240173 scopus 로고
    • Characterization of a cDNA coding for human protein C
    • Foster, D., and E.W. Davie. 1984. Characterization of a cDNA coding for human protein C. Proc. Natl. Acad. Sci. USA. 81:4766-4770.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 4766-4770
    • Foster, D.1    Davie, E.W.2
  • 41
    • 0024460181 scopus 로고
    • Improved retroviral vectors for gene transfer and expression
    • Miller, A.D., and G.J. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. Biotechniques. 7:980-990.
    • (1989) Biotechniques , vol.7 , pp. 980-990
    • Miller, A.D.1    Rosman, G.J.2
  • 42
    • 0027992935 scopus 로고
    • Quantitative evaluation of liver-specific promoters from retroviral vectors after in vivo transduction of hepatocytes
    • Hafenrichter, D.G., S.D. Rettinger, S.C. Kennedy, X. Wu, M.W. Flye, and K.P. Ponder. 1994. Quantitative evaluation of liver-specific promoters from retroviral vectors after in vivo transduction of hepatocytes. Blood. 84:3394-3404.
    • (1994) Blood , vol.84 , pp. 3394-3404
    • Hafenrichter, D.G.1    Rettinger, S.D.2    Kennedy, S.C.3    Wu, X.4    Flye, M.W.5    Ponder, K.P.6
  • 43
    • 0024239024 scopus 로고
    • Construction and use of a safe and efficient amphotropic packaging cell line
    • Markowitz, D., S. Goff, and A. Bank. 1988. Construction and use of a safe and efficient amphotropic packaging cell line. Virology. 167:400-409.
    • (1988) Virology , vol.167 , pp. 400-409
    • Markowitz, D.1    Goff, S.2    Bank, A.3
  • 44
    • 0014604721 scopus 로고
    • Murine sarcoma and leukemia viruses: Assay using clonal lines of contact inhibited mouse cells
    • Jainchill, J.L., S.A. Aaronson, and G.J. Todoro. 1969. Murine sarcoma and leukemia viruses: assay using clonal lines of contact inhibited mouse cells. J. Virol. 4:549-553.
    • (1969) J. Virol. , vol.4 , pp. 549-553
    • Jainchill, J.L.1    Aaronson, S.A.2    Todoro, G.J.3
  • 45
    • 0028158811 scopus 로고
    • Liver-directed gene therapy: Quantitative evaluation of promoter elements using in vivo retroviral transduction
    • Rettinger, S.D., S.C. Kennedy, X. Wu, D. Hafenrichter, M.W. Flye, and K.P. Ponder. 1994. Liver-directed gene therapy: Quantitative evaluation of promoter elements using in vivo retroviral transduction. Proc. Natl. Acad. Sci. USA. 91:1460-1464.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1460-1464
    • Rettinger, S.D.1    Kennedy, S.C.2    Wu, X.3    Hafenrichter, D.4    Flye, M.W.5    Ponder, K.P.6
  • 46
    • 0026023289 scopus 로고
    • Targeted disruption of the c-src protooncogene leads to osteopetrosis in mice
    • Soriano, P., C. Montgomery, R. Geske, and A. Bradley. 1991. Targeted disruption of the c-src protooncogene leads to osteopetrosis in mice. Cell. 64: 693-702.
    • (1991) Cell , vol.64 , pp. 693-702
    • Soriano, P.1    Montgomery, C.2    Geske, R.3    Bradley, A.4
  • 47
    • 0003085947 scopus 로고
    • Immunoassays
    • Cold Spring Harbor Press, Cold Spring Harbor, NY
    • Harlow, E., and D. Lane. 1988. Immunoassays. In Antibodies: A Laboratory Manual. Cold Spring Harbor Press, Cold Spring Harbor, NY. 553-612.
    • (1988) Antibodies: A Laboratory Manual , pp. 553-612
    • Harlow, E.1    Lane, D.2
  • 50
    • 0023620236 scopus 로고
    • The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships
    • Sweetser, D.A., E.H. Birkenmeier, I.J. Klisek, S. Zollman, R.S. Spark, A.J. Mohandes, A.J. Lusis, and J.I. Gordon. 1987. The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. J. Biol. Chem. 262:16060-16071.
    • (1987) J. Biol. Chem. , vol.262 , pp. 16060-16071
    • Sweetser, D.A.1    Birkenmeier, E.H.2    Klisek, I.J.3    Zollman, S.4    Spark, R.S.5    Mohandes, A.J.6    Lusis, A.J.7    Gordon, J.I.8
  • 51
    • 0025792297 scopus 로고
    • Structural features in eukaryotic mRNAs that modulate the initiation of translation
    • Kozak, M. 1991. Structural features in eukaryotic mRNAs that modulate the initiation of translation. J. Biol. Chem. 266:19867-19870.
    • (1991) J. Biol. Chem. , vol.266 , pp. 19867-19870
    • Kozak, M.1
  • 52
    • 0029849764 scopus 로고    scopus 로고
    • A simple and efficient method for the concentration and purification of recombinant retrovirus for increases hepatocyte transduction in vivo
    • Bowles, N.E., R.C. Eisensmith, R. Mohuidden, M. Pyron, and S.L.C. Woo. 1996. A simple and efficient method for the concentration and purification of recombinant retrovirus for increases hepatocyte transduction in vivo. Hum. Gene Ther. 7:1735-1742.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 1735-1742
    • Bowles, N.E.1    Eisensmith, R.C.2    Mohuidden, R.3    Pyron, M.4    Woo, S.L.C.5
  • 55
    • 0025119274 scopus 로고
    • Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease
    • Espana, F., V. Vicente, D. Tabernero, I. Scharrer, and J.H. Griffen. 1990. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thromb. Res. 59:593-608.
    • (1990) Thromb. Res. , vol.59 , pp. 593-608
    • Espana, F.1    Vicente, V.2    Tabernero, D.3    Scharrer, I.4    Griffen, J.H.5
  • 58
    • 0029125979 scopus 로고
    • A review of mutations causing deficiencies of antithrombin, protein C, and protein S
    • Aiach, M., S. Gandrille, and J. Emmerich. 1995. A review of mutations causing deficiencies of antithrombin, protein C, and protein S. Thromb. Haemostasis. 74:81-89.
    • (1995) Thromb. Haemostasis , vol.74 , pp. 81-89
    • Aiach, M.1    Gandrille, S.2    Emmerich, J.3
  • 61
    • 0343332836 scopus 로고    scopus 로고
    • Characterization of the anticoagulant protein C by targeted inactivation in mice
    • Abstr.
    • Jalbert, L.R., E.D. Rosen, P. Carmeliet, F.J. Castellino, and D. Collen. 1996. Characterization of the anticoagulant protein C by targeted inactivation in mice. Blood. 90:258a. (Abstr.)
    • (1996) Blood , vol.90
    • Jalbert, L.R.1    Rosen, E.D.2    Carmeliet, P.3    Castellino, F.J.4    Collen, D.5
  • 63
    • 1842387143 scopus 로고
    • An alternative approach to somatic cell gene therapy
    • St. Louis, D., and I.M. Verma. 1988. An alternative approach to somatic cell gene therapy. Proc. Natl. Acad. Sci. USA. 85:3150-3154.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3150-3154
    • St. Louis, D.1    Verma, I.M.2
  • 64
    • 0026511128 scopus 로고
    • Expression of human factor IX in mice after injection of genetically modified myoblasts
    • Yao, S.-N., and K. Kurachi. 1992. Expression of human factor IX in mice after injection of genetically modified myoblasts. Proc. Natl. Acad. Sci. USA. 89:3357-3361.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3357-3361
    • Yao, S.-N.1    Kurachi, K.2
  • 65
    • 0000522927 scopus 로고
    • 131 metabolism in human subjects: Demonstration of insulin binding globulin in the circulation of insulin treated subjects
    • 131 metabolism in human subjects: demonstration of insulin binding globulin in the circulation of insulin treated subjects. J. Clin. Invest. 35: 170-190.
    • (1956) J. Clin. Invest. , vol.35 , pp. 170-190
    • Berson, S.A.1    Yalow, R.S.2    Bauman, A.3    Rothschild, M.A.4    Newerly, K.5
  • 66
    • 2642645629 scopus 로고
    • The effect of insulin-binding serum globulin on insulin requirements
    • Prout, T.E., and R.B. Katims. 1959. The effect of insulin-binding serum globulin on insulin requirements. Diabetes. 8:425-431.
    • (1959) Diabetes , vol.8 , pp. 425-431
    • Prout, T.E.1    Katims, R.B.2
  • 67
    • 0014062690 scopus 로고
    • The initial rapid-phase disappearance of intravenous radioinsulin in diabetes
    • McAdams, G.B., K.R. Knox, D.S. Wilcox, and R. Jensen. 1967. The initial rapid-phase disappearance of intravenous radioinsulin in diabetes. J. Nucl. Med. 8:173-178.
    • (1967) J. Nucl. Med. , vol.8 , pp. 173-178
    • McAdams, G.B.1    Knox, K.R.2    Wilcox, D.S.3    Jensen, R.4
  • 68
    • 0016791418 scopus 로고
    • Insulin antibodies and the control of diabetes
    • Dixon, K., P.D. Exon, and J.M. Malins. 1975. Insulin antibodies and the control of diabetes. Q. J. Med. 176:543-553.
    • (1975) Q. J. Med. , vol.176 , pp. 543-553
    • Dixon, K.1    Exon, P.D.2    Malins, J.M.3
  • 71
    • 0027216474 scopus 로고
    • Antibody response in patients with Gaucher disease after repeated infusion with macrophage-targeted glucocerebrosidase
    • Richards, S.M., T.A. Olson, and J.M. McPherson. 1993. Antibody response in patients with Gaucher disease after repeated infusion with macrophage-targeted glucocerebrosidase. Blood. 82:1402-1409.
    • (1993) Blood , vol.82 , pp. 1402-1409
    • Richards, S.M.1    Olson, T.A.2    McPherson, J.M.3
  • 72
    • 0027218354 scopus 로고
    • Enzyme therapy in Gaucher Disease type 1: Dosage efficacy and adverse effects in 33 patients treated for 6 to 24 months
    • Pastores, G.M., A.R. Sibille, and G.A. Grabowski. 1993. Enzyme therapy in Gaucher Disease type 1: dosage efficacy and adverse effects in 33 patients treated for 6 to 24 months. Blood. 82:408-416.
    • (1993) Blood , vol.82 , pp. 408-416
    • Pastores, G.M.1    Sibille, A.R.2    Grabowski, G.A.3
  • 73
    • 0030908645 scopus 로고    scopus 로고
    • Enzyme therapy in Gaucher disease type 1: Effect of neutralizing antibodies to acid beta-glucuronidase
    • Ponce, E., J. Moskovitz, and G. Grabowski. 1997. Enzyme therapy in Gaucher disease type 1: effect of neutralizing antibodies to acid beta-glucuronidase. Blood. 90:43-48.
    • (1997) Blood , vol.90 , pp. 43-48
    • Ponce, E.1    Moskovitz, J.2    Grabowski, G.3
  • 74
    • 0029849258 scopus 로고    scopus 로고
    • Portal branch occlusion safely facilitates in vivo retroviral vector transduction of rat liver
    • Bowling, W.M., S.C. Kennedy, S.-R. Cai, J.R. Duncan, M.W. Flye, and K.P. Ponder. 1996. Portal branch occlusion safely facilitates in vivo retroviral vector transduction of rat liver. Hum. Gene Ther. 7:2113-2121.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 2113-2121
    • Bowling, W.M.1    Kennedy, S.C.2    Cai, S.-R.3    Duncan, J.R.4    Flye, M.W.5    Ponder, K.P.6
  • 75
    • 2642712731 scopus 로고    scopus 로고
    • Embolization of portal vein branches induces hepatocyte replication in swine. A potential step in hepatic gene therapy
    • In press
    • Duncan, J.R., M. Hicks, S.-R. Cai, E.M. Brunt, and K.P. Ponder. 1998. Embolization of portal vein branches induces hepatocyte replication in swine. A potential step in hepatic gene therapy. Radiology. In press.
    • (1998) Radiology
    • Duncan, J.R.1    Hicks, M.2    Cai, S.-R.3    Brunt, E.M.4    Ponder, K.P.5
  • 76
    • 0030452791 scopus 로고    scopus 로고
    • Proliferation induced by keratinocyte growth factor enhances in vivo retroviral vector-mediated gene transfer to mouse hepatocytes
    • Bosch, A., P.B. McCray, S.M.W. Chang, T.R. Ulish, W.S. Simonet, D.J. Jolly, and B.L. Davidson. 1996. Proliferation induced by keratinocyte growth factor enhances in vivo retroviral vector-mediated gene transfer to mouse hepatocytes. J. Clin. Invest. 98:2683-2687.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2683-2687
    • Bosch, A.1    McCray, P.B.2    Chang, S.M.W.3    Ulish, T.R.4    Simonet, W.S.5    Jolly, D.J.6    Davidson, B.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.