Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers

Journal of Virology

Volumn 72, Issue 5, 1998, Pages 4212-4223

  Jooss, Karin ^b   Yang, Yiping ^b   Fisher, Krishna J ^b   Wilson, James M ^a,b  

^a WISTAR INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DNA; GENE PRODUCT; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; GENE THERAPY; GENETIC TRANSDUCTION; IMMUNE RESPONSE; MALE; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; VIRUS RECOMBINANT;

EID: 0031969428     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.5.4212-4223.1998     Document Type: Article

References (54)

1. Armentano, D., J. Zabner, C. Sacks, C. S. Sookedo, M. P. Smith, J. A. St. George, S. C. Wadsworth, A. E. Smith, and R. J. Gregory. 1997. Effect of the E4 region on the persistence of transgene expression from adenovirus vectors. J. Virol. 71:2408-2416.
2. Bhardwaj, N., A. Bender, N. Gonzalez, L. K. Bui, M. C. Garrett, and R. M. Steinman. 1994. Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells. J. Clin. Invest. 94:797-807.
3. Bronte, V., M. W. Carroll, T. J. Goletz, M. Wang, W. W. Overwijk, F. Marincola, S. A. Rosenberg, B. Moss, and N. P. Restifo. 1997. Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine. Proc. Natl. Acad. Sci. USA 94:3183-3188.
4. Crystal, R. 1995. Transfer of genes to humans: early lessons and obstacles to success. Science 270:404-410.
5. Descamps, V., M. T. Duffour, M. C. Mathieu, N. Fernandez, L. Cordier, M. A. Abina, E. Kremer, M. Perricaudet, and H. Haddada. 1996. Strategies for cancer gene therapy using adenoviral vectors. J. Mol. Med. 74:183-189.
6. Doe, B., M. Selby, S. Barnett, J. Baenziger, and C. M. Walker. 1996. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells. Proc. Natl. Acad. Sci. USA 93:8578-8583.
7. Ertl, H. C., and Z. Xiang. 1996. Novel vaccine approaches. J. Immunol. 156:3579-3582.
8. Fang, B., H. Wang, G. Gordon, D. A. Bellinger, M. S. Read, K. M. Brinkhous, S. L. C. Woo, and R. C. Eisensmith. 1996. Lack of persistence of E1-recombinant adenoviral vectors containing a temperature-sensitive E2a mutation in immunocompetent mice and hemophilia B dogs. Gene Ther. 3:217-222.
9. Ferrari, F. K., T. Samulski, T. Shenk, and R. J. Samulski. 1996. Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J. Virol. 70:3227-3234.
10. Fisher, K. J., G.-P. Gao, M. D. Weitzman, R. DeMatteo, J. F. Burda, and J. M. Wilson. 1996. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. J. Virol. 70:520-532.
11. Fisher, K. J., K. Jooss, J. Alston, Y. Yang, S. E. Haecker, K. High, R. Pathak, S. E. Raper, and J. M. Wilson. 1997. Recombinant adeno-associated virus for muscle directed gene therapy. Nat. Med. 3:306-312.
12. Flotte, T. R., S. A. Afione, C. Conrad, S. A. McGrath, R. Solow, H. Oka, P. L. Zeitlin, W. B. Guggino, and B. J. Carter. 1993. Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proc. Natl. Acad. Sci. USA 90:10613-10617.
13. Fu, T.-M., J. B. Ulmer, M. J. Caulfield, R. R. Deck, A. Friedman, S. Wang, X. Liu, J. J. Donnelly, and M. A. Liu. 1997. Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol. Med. 3:362-371.
14. Gao, G.-P., Y. Yang, and J. M. Wilson. 1996. Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy. J. Virol. 70:8934-8943.
15. Goebels, N., D. Michaelis, H. Wekerly, and R. Hohlfeld. 1992. Human myoblasts as antigen-presenting cells. J. Immunol. 149:661-667.
16. Hamilton-Easton, A. M., and M. Eichelberger. 1995. Virus-specific antigen presentation by different subsets of cells from lung and mediastinal lymph node tissues of influenza virus-infected mice. J. Virol. 69:6359-6366.
17. Herzog, R. W., J. N. Hagstrom, S.-H. Kung, S. J. Tai, J. M. Wilson, K. J. Fisher, and K. A. High. 1997. Stable gene transfer and expression of human factor IX following intramuscular injection of recombinant AAV. Proc. Natl. Acad. Sci. USA 94:5804-5809.
18. Hohlfeld, R., and A. G. Engel. 1990. Induction of HLA-DR expression on human myoblasts with interferon-γ. Am. J. Pathol. 136:503-508.
19. Huang, A. Y. C., A. T. Bruce, D. M. Pardoll, and H. Z. Levitsky. 1996. In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter. Immunity 4:349-355.
20. Huang, A. Y. C., P. Golumbek, M. Ahmadzadeh, E. Jaffee, D. Pardoll, and H. Levitsky. 1994. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264:961-965.
21. Kaplitt, M. G., P. Leone, R. J. Samulski, X. Xiao, D. W. Pfaff, K. L. O'Malley, and M. J. During. 1994. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat. Genet. 8:148-153.
22. Kay, M. A., A.-X. Holterman, L. Meuse, A. Gown, H. D. Ochs, P. S. Linsley, and C. B. Wilson. 1995. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nat. Genet. 11:191-197.
23. Kessler, P. D., G. Podsakoff, X. Chen, S. A. McQuiston, P. C. Colosi, L. A. Matelis, G. J. Kurtzman, and B. J. Byrne. 1996. Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein. Proc. Natl. Acad. Sci. USA 93:14082-14087.
24. Kim, J. J., M. L. Bagarazzi, N. Trivedi, Y. Hu, K. Kazahaya, D. M. Wilson, R. Ciccarelli, M. A. Chattergoon, K. Dang, S. Mahalingam, A. A. Chalian, M. G. Agadjanyan, J. D. Boyer, B. Wang, and D. B. Weiner. 1997. Engineering of in vivo immune responses to DNA immunization via co-delivery of costimulatory molecule genes. Nat. Biotechnol. 15:641-646.
25. Kohn, D. B., and N. Sarver. 1996. Gene therapy for HTV-1 infection. Adv. Exp. Med. Biol. 394:421-428.
26. Kotin, R. M. 1994. Prospects for the use of adeno-associated virus as a vector for human gene therapy. Hum. Gene Ther. 5:793-801.
27. Kozarsky, K. F., K. Jooss, M. Donahee, J. F. Strauss, and J. M. Wilson. 1996. Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nat. Genet. 13:54-61.
28. Lei, D., M. Lehmann, J. E. Shellito, S. Nelson, A. Siegling, H.-D. Volk, and J. K. Kolls. 1996. Nondepleting anti-CD4 antibody treatment prolongs lung-directed El-deleted adenovirus-mediated gene expression in rats. Hum. Gene Ther. 7:2273-2279.
29. Lew, D., S. E. Parker, T. Latimer, A. M. Abai, A. Kuwahara-Rundell, S. G. Doh, Z.-Y. Yang, D. Laface, S. H. Gromkowski, G. J. Nabel, M. Manthorpe, and J. Norman. 1995. Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice. Hum. Gene Ther. 6:553-564.
30. Mantegazza, R., S. M. Hughes, D. Mitchell, M. Travis, H. M. Blau, and L. Steinman. 1991. Modulation of MHC class II antigen expression in human myoblasts after treatment with IFN-γ. Neurology 41:1128-1132.
31. Miller, J. L., R. E. Donahue, S. E. Sellers, R. J. Samulski, N. S. Young, and A. W. Nienhuis. 1994. Recombinant adeno-associated virus (rAAV)-mediated expression of a human γ-globin gene in human progenitor-derived erythroid cells. Proc. Natl. Acad. Sci. USA 91:10183-10187.
32. Mullen, C. A., and R. M. Blaese. 1996. Gene therapy of cancer. Cancer Chemother. Biol. Response Modifiers 16:285-294.
33. Nabel, G. J., Z. Y. Yang, E. G. Nabel, K. Bishop, M. Marquet, M. Felgner, D. Gordon, and A. E. Chang. 1995. Direct gene transfer for treatment of human cancer. Ann. N.Y. Acad. Sci. 772:227-231.
34. Parker, S. E., H. L. Vahlsing, L. M. Serfilippi, C. L. Franklin, S. G. Doh, S. H. Gromkowski, D. Lew, M. Manthorpe, and J. Norman. 1995. Cancer gene therapy using plasmid DNA: safety evaluation in rodents and non-human primates. Hum. Gene Ther. 6:575-590.
35. Plautz, G. E., Z.-Y. Yang, B.-Y. Wu, X. Gao, L. Huang, and G. J. Nabel. 1993. Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc. Natl. Acad. Sci. USA 90:4645-4649.
36. Podsakoff, G., K. K. Wong, and S. Chatterjee. 1994. Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors. J. Virol. 68: 5656-5666.
37. Poeschla, E. M., and F. Wong-Staal. 1996. Gene therapy and HIV disease, p. 1-45. In P. Volberg and M. A. Jacobson (ed.), AIDS clinical review, 1995/ 1996. Marcel Dekker, Inc., New York, N.Y.
38. Roy, R., G. Danserau, J. B. Tremblay, M. Belles-Isles, J. Huard, C. Labrecque, and J. P. Bouchard. 1991. Expression of major histocompatibility complex antigens on human myoblasts. Transplant. Proc. 23:799-801.
39. Tripathy, S. K., H. B. Black, E. Goldwasser, and J. M. Leiden. 1996. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nat. Med. 2:545-550.
40. Ulmer, J. B., J. J. Donnelley, S. E. Parker, G. H. Rhodes, P. L. Felgner, V. J. Dwarki, S. J. Gromkwoski, R. R. Deck, C. M. DeWitt, A. Friedman, L. A. Hawe, K. R. Leander, D. Martinez, H. C. Perry, J. W. Shiver, D. L. Montgomery, and M. A. Liu. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745-1749.
41. VanGinkel, F. W., C. Liu, J. W. Simecka, J.-Y. Dong, T. Greenway, R. A. Frizzell, H. Kiyono, J. R. McGhee, and D. W. Pascual. 1995. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and β-galactosidase. Hum. Gene Ther. 6:895-903.
42. Walsh, C. E., A. W. Neinhuis, R. J. Samulski, M. G. Brown, J. L. Miller, N. S. Young, and J. M. Liu. 1994. Phenotypic correction of fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector. J. Clin. Invest. 94:1440-1448.
43. Whartenby, K. A., C. N. Abbound, A. J. Marrogi, R. Ramesh, and S. M. Freeman. 1995. The biology of cancer gene therapy. Lab. Invest. 72:131-145.
44. Wilson, J. M. 1995. Gene therapy for cystic fibrosis: challenges and future directions. J. Clin. Invest. 96:2574-2554.
45. Xiao, X., J. Li, and R. J. Samulski. 1996. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J. Virol. 70:8098-8108.
46. Yang, Y., H. C. J. Ertl, and J. M. Wilson. 1994. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1:433-442.
47. Yang, Y., Z. Xiang, H. C. J. Ertl, and J. M. Wilson. 1995. Upregulation of class I major histocompatibility complex antigens by interferon γ is necessary for T-cell-mediated elimination of recombinant adenoviruses-infected hepatocytes in vivo. Proc. Natl. Acad. Sci. USA 92:7257-7261.
48. Yang, Y., Q. Li, H. C. J. Ertl, and J. M. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004-2015.
49. Yang, Y., F. A. Nunes, K. Berencsi, E. Gonczol, J. F. Engelhardt, and J. M. Wilson. 1995. Inactivation of E2a in recombinant adenovirus improves the prospect for gene therapy in cystic fibrosis. Nat. Genet. 7:362-369.
50. Yang, Y., G. Trinchieri, and J. M. Wilson. 1995. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nat. Med. 1:890-893.
51. Yang, Y., Q. Su, and J. M. Wilson. 1996. Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J. Virol. 70:7209-7212.
52. Yang, Y., S. E. Haecker, Q. Su, and J. M. Wilson. 1996. Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle. Hum. Mol. Gen. 5:1703-1712.
53. Yang, Y., K. Jooss, Q. Su, H. C. J. Ertl, J. M. Wilson. 1996. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Ther. 3:137-144.
54. Zsengeller, Z. K., S. E. Wert, W. M. Hull, X. Hu, S. Yei, B. C. Trapnell, and J. A. Whitsett. 1995. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum. Gene Ther. 6:457-467.