Genetic approaches to the investigation of rheumatoid arthritis

Current Opinion in Rheumatology

Volumn 14, Issue 3, 2002, Pages 260-269

  Barton, Anne ^a   Ollier, William ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN;

CASE CONTROL STUDY; DISEASE SEVERITY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HLA SYSTEM; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; POPULATION RESEARCH; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; GENETIC PREDISPOSITION TO DISEASE; HLA ANTIGENS; HUMANS; LINKAGE (GENETICS); MAJOR HISTOCOMPATIBILITY COMPLEX; SEVERITY OF ILLNESS INDEX;

EID: 0036226581     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-200205000-00012     Document Type: Review

References (97)

1. Genetic epidemiology of rheumatoid disease
2. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins
3. Association of B-cell alloantigen DRw4 with rheumatoid arthritis
4. B-lymphocyte allo-antigenes, cellular expression and disease significance with special reference to rheumatoid arthritis
5. Population genetics of rheumatoid arthritis
6. The shared epitope hypothesis
7. Does the HLA-DRB1 shared epitope really contribute that much to the development or severity of rheumatoid arthritis?
8. Association of MHC and rheumatoid arthritis. Association of RA with HLA- DR4: The role of repertoire selection
9. Dog MHC alleles containing the human RA shared epitope confer susceptibility to canine rheumatoid arthritis
10. Could HLA-DRB1 be the protective locus in rheumatoid arthritis?
11. Protection against severe disease is conferred by DERAA-bearing HLA-DRB1 alleles among HLA-DQ3 and HLA-DQ5 positive rheumatoid arthritis patients
12. Rheumatoid arthritis in southern Spain: Toward elucidation of a unifying role of the HLA class II region in disease predisposition
13. An HLA-DRB1-derived peptide associated with protection against rheumatoid arthritis is naturally processed by human APCs
14. Distribution of HERV-LTR elements in the 5′-flanking region of HLA-DQB1 and association with autoimmunity
15. Association of MHC and rheumatoid arthritis. HLA-DR4 and rheumatoid arthritis: Studies in mice and men
16. Influence of shared epitope-negative HLA-DRB1 alleles on genetic susceptibility to rheumatoid arthritis
17. Influence of non-inherited maternal HLA antigens on occurrence of rheumatoid arthritis
18. Noninherited maternal antigens do not increase the susceptibility for familial rheumatoid arthritis
19. Tumor necrosis factor microsatellites and HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles in Peruvian patients with rheumatoid arthritis
20. HLA haplotype analysis in Finnish patients with rheumatoid arthritis
21. HLA antigen associations with extra-articular rheumatoid arthritis
22. Association of MHC and rheumatoid arthritis: HLA polymorphisms in phenotypic variants of rheumatoid arthritis
23. Increased frequency of HLA-DRB1 *0401 in patients with RA and bronchiectasis
24. Tumor necrosis factor promoter polymorphisms in patients with rheumatoid arthritis in Taiwan
25. Association of the TNF +489 polymorphism with susceptibility and radiographic damage in rheumatoid arthritis
26. Allele-specific quantification of tumor necrosis factor alpha (TNF) transcription and the role of promoter polymorphisms in rheumatoid arthritis patients and healthy individuals
27. Primary association of a MICA allele with protection against rheumatoid arthritis
28. HFE gene mutations in patients with rheumatoid arthritis
29. A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localised within a 70Kb interval telomeric of the TNF genes in the HLA class III region
30. The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci
31. Evidence that the MHC region on chromosome 6p harbours more than one RA susceptibility locus
32. Happy families
33. New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study
34. Identification of the gene loci that predispose to rheumatoid arthritis
35. A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases
36. Whole genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 United Kingdom affected sibling pairs
37. Clinical and immunogenetic characteristics of European multicase rheumatoid arthritis families
38. The inheritance of rheumatoid arthritis in Iceland
39. Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region
40. Rheumatoid arthritis families show locus heterogeneity for CRH and HLA
41. Genomic sequence and variability in the RA-associated CRH region (8q13)
42. A CRH genomic region haplotype in familial and sporadic rheumatoid arthritis
43. High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis
44. Linkage and association analysis of candidate genes in rheumatoid arthritis
45. Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: Comparison with the shared epitope
46. Linkage of rheumatoid arthritis to insulin-dependent diabetes mellitus loci
47. Additional support for an autoimmune susceptibility gene(s) at 6q24-27
48. Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease
49. Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to, and severity of, rheumatoid arthritis
50. Role of interferon-gamma gene in rheumatoid arthritis?
51. Interferon gamma gene in rheumatoid arthritis
52. Interferon-gamma microsatellite and rheumatoid arthritis
53. Immunogenetic markers and seropositivity predict radiologic progression in early rheumatoid arthritis independent of disease activity
54. Prognostic factors for radiographic damage in early rheumatoid arthritis: A multiparameter prospective study
55. The association of variant mannose-binding lectin genotypes with radiographic outcome in rheumatoid arthritis
56. Mannan binding protein in sera positive for rheumatoid factor
57. Absence of an association between mannose-binding lectin polymorphism and rheumatoid arthritis
58. Two-edged role of mannose binding lectin in rheumatoid arthritis: A cross sectional study
59. Mannose-binding lectin and rheumatoid arthritis in southern Chinese
60. The influence of mannose binding lectin polymorphisms on disease outcome in early polyarthritis
61. Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis: A prospective study
62. Linkage disequilibrium as a gene-mapping tool
63. Association study designs for complex diseases
64. Use of unlinked genetic markers to detect population stratification in association studies
65. Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians
66. Association between TNFR2 and familial but not sporadic rheumatoid arthritis provides evidence for genetic heterogeneity
67. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling
68. Evaluation of candidate genes in case-control studies: A statistical method to account for related subjects
69. HLA-DRB1 genes and patients with late onset rheumatoid arthritis
70. Seronegative rheumatoid arthritis in elderly and polymyalgia rheumatica have similar patterns of HLA association
71. SNPing away at complex diseases: Analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
72. Haplotype tagging for the identification of common disease genes
73. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus
74. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
75. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
76. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
77. Intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in Italian patients with rheumatoid arthritis
78. Association of vitamin D receptor genotypes with early onset rheumatoid arthritis
79. Linkage disequilibrium at the Fc gamma receptor locus and association of an FcGR haplotype with rheumatoid arthritis (RA) in two distinct ethnic groups
80. The FcGRIIIa 158F/V variant does not predispose to RA
81. Cytotoxic T lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism in early rheumatoid arthritis
82. A single nucleotide polymorphism in exon 1 of cytotoxic T-lymphocyte- associated-4 (CTLA-4) is not associated with rheumatoid arthritis
83. CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis
84. CTLA4 polymorphisms in Spanish patients with rheumatoid arthritis
85. Interleukin-1 beta and interleukin-1 receptor antagonist gene polymorphisms in rheumatoid arthritis
86. Predictive value of interleukin 1 gene polymorphisms for surgery
87. IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: Interaction with their plasma levels
88. Investigation of novel polymorphisms within the 3′ region of the IL-6 gene in patients with rheumatoid arthritis using Genescan analysis
89. A DNA polymorphism at the alpha2-macroglobulin gene is associated with the severity of rheumatoid arthritis
90. Genetic polymorphism of IL-12 p40 gene in immune-mediated disease
91. Mannose binding lectin (MBL) gene mutation is not a risk factor for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Japanese
92. Presence of four major haplotypes in human BCMA gene: Lack of association with systemic lupus erythematosus and rheumatoid arthritis
93. CCR5 (chemokine receptor-5) DNA-polymorphism influences the severity of rheumatoid arthritis
94. Association of rheumatoid arthritis with a functional chemokine receptor, CCR5
95. CC chemokine receptor 5 polymorphism in rheumatoid arthritis
96. Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis
97. Interleukin-1 B, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 gene polymorphisms: Relation to occurrence and severity of rheumatoid arthritis