Association of MHC and rheumatoid arthritis HLA polymorphisms in phenotypic variants of rheumatoid arthritis

Arthritis Research

Volumn 2, Issue 3, 2000, Pages 212-216

  Weyand, C M ^a   Goronzy, J J ^a  

^a MAYO CLINIC   (United States)

Author keywords

Disease risk genes; Heterogeneity; Synovitis; T cells; Vascular injury

Indexed keywords

HLA ANTIGEN; HLA DR ANTIGEN; T LYMPHOCYTE RECEPTOR;

ALLELE; BLOOD VESSEL INJURY; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC RISK; GENOTYPE; HLA SYSTEM; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MORBIDITY; MORTALITY; PATHOGENESIS; PHENOTYPE; PROTEIN INTERACTION; REVIEW; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; RISK ASSESSMENT; SYNOVITIS; T LYMPHOCYTE SUBPOPULATION;

ARTHRITIS, RHEUMATOID; HLA ANTIGENS; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; PHENOTYPE; POLYMORPHISM, GENETIC;

EID: 0034467066     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar90     Document Type: Review

References (41)

1. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
2. Heterogeneity of rheumatoid arthritis: From phenotypes to genotypes
3. Pathogenesis of rheumatoid arthritis
4. The influence of sex on the phenotype of rheumatoid arthritis
5. Extra-articular rheumatoid arthritis: Prevalence and mortality
6. Mortality in rheumatoid arthritis
7. Marker antibodies of rheumatoid arthritis: Diagnostic and pathogenetic implications
8. Prognostic criteria in rheumatoid arthritis: Can we predict which patients will require specific anti-rheumatoid treatment?
9. Tissue cytokine patterns distinguish variants of rheumatoid synovitis
10. The genetic contribution to the pathogenesis of rheumatoid arthritis
11. HLA-DR and the development of rheumatoid arthritis
12. Major histocompatibility complex-directed susceptibility to rheumatoid arthritis
13. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
14. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis
15. T cell receptor repertoire in rheumatoid arthritis
16. Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis
17. Perturbation of the T cell repertoire in rheumatoid arthritis
18. - T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity
19. Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis
20. Production of cytokines and metalloproteinases in rheumatoid synovitis is T cell dependent
21. Multiple mechanisms support oligoclonal T cell expansion in rheumatoid synovitis
22. High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen-driven immune responses
23. Germinal centers: Form and function
24. Lymphocyte development and selection in germinal centers
25. Evaluating candidate autoantigens in rheumatoid arthritis
26. HLA-DRB1 alleles as severity markers in RA
27. Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis
28. HLA markers and prediction of clinical course and outcome in rheumatoid arthritis
29. HLA-DRB1*04 subtypes are associated with increased inflammatory activity in early rheumatoid arthritis
30. Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome
31. HLA-DR1, DR4, and DRB1 disease related subtypes in rheumatoid arthritis. Association with susceptibility but not severity in a city wide community based study
32. Only high disease activity and positive rheumatoid factor indicate poor prognosis in patients with early rheumatoid arthritis treated with 'sawtooth' strategy
33. Aberrations in the primary T-cell receptor repertoire as a predisposition for synovial inflammation in rheumatoid arthritis
34. The role of CD8+ CD40L+ T cells in the formation of germinal centers in rheumatoid synovitis
35. HLA heterozygosity contributes to susceptibility to rheumatoid arthritis
36. Expansion of unusual CD4+ T cells in severe rheumatoid arthritis
37. Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity
38. Functional subsets of CD4 T cells in rheumatoid synovitis
39. - T cells
40. Perturbation of the T-cell repertoire in patients with unstable angina