Presence of four major haplotypes in human BCMA gene: Lack of association with systemic lupus erythematosus and rheumatoid arthritis

Genes and Immunity

Volumn 2, Issue 5, 2001, Pages 276-279

  Kawasaki, A ^a   Tsuchiya, N ^a   Fukazawa, T ^b   Hashimoto, H ^b   Tokunaga, K ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

BCMA; Haplotype; Polymorphism; RA; SLE

Indexed keywords

B CELL MATURATION ANTIGEN; TNFRSF17 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR;

ADULT; ARTICLE; B LYMPHOCYTE; FEMALE; GENETIC POLYMORPHISM; GENETICS; HAPLOTYPE; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; MOLECULAR GENETICS; RHEUMATOID ARTHRITIS; RISK FACTOR; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; ARTHRITIS, RHEUMATOID; B-CELL MATURATION ANTIGEN; B-LYMPHOCYTES; FEMALE; HAPLOTYPES; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; RECEPTORS, TUMOR NECROSIS FACTOR; RISK FACTORS;

EID: 0035432985     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363770     Document Type: Article

References (21)

1. Laabi Y, Gras MP, Carbonnel F et al. A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma. EMBO J 1992; 11: 3897-3904.
2. Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A. The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed. Nucleic Acids Res 1994; 22: 1147-1154.
3. Madry C, Laabi Y, Callebaut I et al. The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily. Int Immunol 1998; 10: 1693-1702.
4. von Bulow GU, Bram RJ. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. Science 1997; 278: 138-141.
5. Gross JA, Johnston J, Mudri S et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 2000; 404: 995-999.
6. Moore PA, Belvedere O, Orr A et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999; 285: 260-263.
7. Schneider P, MacKay F, Steiner V et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999; 189: 1747-1756.
8. Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukocyte Biol 1999; 65: 680-683.
9. Nardelli B, Belvedere O, Roschke V et al. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 2001; 97: 198-204.
10. Mackay F, Woodcock SA, Lawton P et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 1999; 190: 1697-1710.
11. Khare SD, Sarosi I, Xia XZ et al. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc Natl Acad Sci USA 2000; 97: 3370-3375.
12. Thompson JS, Schneider P, Kalled SL et al. BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population. J Exp Med 2000; 192: 129-135.
13. Do RK, Hatada E, Lee H, Tourigny MR, Hubert D, Chen-Kiang S. Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response. J Exp Med 2000; 192: 953-964.
14. Batten M, Groom J, Cachero TG et al. BAFF mediates survival of peripheral immature B lymphocytes. J Exp Med 2000; 192: 1453-1466.
15. Shu HB, Johnson H. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. Proc Natl Acad Sci USA 2000; 97: 9156-9161.
16. Hatzoglou A, Roussel J, Bourgeade MF et al. TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. J Immunol 2000; 165: 1322-1330.
17. Yu G, Boone T, Delaney J et al. APRIL and TALL-1 and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol 2000; 1: 252-257.
18. Zhang J, Roschke V, Baker KP et al. Cutting edge: a role for B Lymphocyte Stimulator in systemic lupus erythematosus. J Immunol 2001; 166: 6-10.
19. Roetto A, Cicilano M, Gottardi E et al. A frequent polymorphism in the 5′ region of the BCMA gene. Mol Cell Probes 1997; 11: 311-312.
20. Dunnen JT, Antonarakis SE. Mutation nomenclature extensions and suggestions to describe complex mutations. Hum Mutat 2000; 15: 7-12.
21. Nomenclature for the description of sequence variations. (http://www.dmd.nl/mutnomen.html)