Distribution of HERV-LTR elements in the 5′-flanking region of HLA-DQB1 and association with autoimmunity

Immunogenetics

Volumn 53, Issue 2, 2001, Pages 114-118

  Pascual, M ^a   Martin, J ^a   Nieto, A ^a   Giphart, M J ^a   Van der Slik, A R ^a   De Vries, R R P ^a   Zanelli, E ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

Autoimmunity; HERV LTR; HLA DQB1; IDDM; RA

Indexed keywords

DNA; HLA DQ ANTIGEN; NUCLEOTIDE;

ALLELE; ARTICLE; AUTOIMMUNITY; BASE PAIRING; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA FLANKING REGION; EXON; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; LONG TERMINAL REPEAT; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PHYLOGENY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ALLELES; ARTHRITIS, RHEUMATOID; AUTOIMMUNITY; B-LYMPHOCYTES; BASE SEQUENCE; CASE-CONTROL STUDIES; CELL LINE; DIABETES MELLITUS, TYPE 1; DNA PRIMERS; ENDOGENOUS RETROVIRUSES; EXONS; HLA-DQ ANTIGENS; HUMANS; POLYMORPHISM, GENETIC; SPAIN; TERMINAL REPEAT SEQUENCES;

UNIDENTIFIED RETROVIRUS;

EID: 0035075310     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510100307     Document Type: Article

References (14)

1. Evolutionary dynamics of non-coding sequences within the class II region of the human MHC
2. The presence or absence of a retroviral long terminal repeat influences the genetic risk for type 1 diabetes conferred by human leukocyte antigen DQ haplotypes
3. Intronic sequence motifs of HLA-DQB1 are shared between humans, apes and Old World monkeys, but a retroviral LTR element (DQLTR3) is human specific
4. Insulin-dependent diabetes mellitus in non-DR3/non-DR4 subjects
5. Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC
6. Endogenous retroviral long terminal repeats within the HLA-DQ locus
7. Resolution of the HLA-DRB6 puzzle: A case of grafting a de novo-generated exon on an existing gene
8. Complete sequence and gene map of a human major histocompatibility complex
9. MHC class-II molecules and autoimmunity
10. Rheumatoid arthritis in southern Spain: Towards a unifying role of the class II region in disease predisposition
11. An endogenous retroviral long terminal repeat at the HLA-DQB1 gene locus confers susceptibility to rheumatoid arthritis
12. Susceptibility to type I diabetes: HLA-DQ and DR revisited
13. Presence of retroelements reveal the evolutionary history of the human DR haplotypes
14. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus