Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor

Pain

Volumn 96, Issue 1-2, 2002, Pages 107-118

  Jarvis, Michael F ^a   Yu, Haixia ^a   McGaraughty, Steve ^a   Wismer, Carol T ^a   Mikusa, Joe ^a   Zhu, Chang ^a   Chu, Katharine ^a   Kohlhaas, Kathy ^a   Cowart, Marlon ^a   Lee, Chih Hung ^a   Stewart, Andrew O ^a   Cox, Bryan F ^a   Polakowski, James ^a   Kowaluk, Elizabeth A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Adenosine; Adenosine kinase; Allodynia; Hyperalgesia; Inflammation

Indexed keywords

(2',3' DIHYDROXY 4' AMINOCYCLOPENTYL) 4 AMINO 5 BROMO PYRROLO[2,3 A]PYRIMIDINE; 4 AMINO 5 (3 BROMOPHENYL) 7 (6 MORPHOLINOPYRIDIN 3 YL)PYRIDO[2,3 D]PYRIMIDINE; 5' DEOXY 5 IODOTUBERCIDIN; A 286501; ABT 702; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DEAMINASE; ADENOSINE KINASE INHIBITOR; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FORMALDEHYDE; MYELOPEROXIDASE; NALOXONE; NEUROTRANSMITTER RECEPTOR; PYRIMIDINE DERIVATIVE; STREPTOZOCIN; THEOPHYLLINE; TUBERCIDIN DERIVATIVE; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART RATE; HEMODYNAMICS; HUMAN; HUMAN CELL; HYPERALGESIA; IC 50; LATENT PERIOD; MOTOR PERFORMANCE; NERVE LIGATION; NEUTROPHIL; NOCICEPTION; NONHUMAN; PAIN; PAW EDEMA; PRIORITY JOURNAL; RAT; SPINAL NERVE;

ADENOSINE KINASE; ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; GASTRIC ACID; HEART RATE; HYPERALGESIA; INJECTIONS, INTRAPERITONEAL; MOTOR ACTIVITY; NEURALGIA; NOCICEPTORS; PYRIMIDINES; RATS;

EID: 0036217376     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(01)00435-3     Document Type: Article

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