Exogenous and endogenous adenosine enhance the spinal antiallodynic effects of morphine in a rat model of neuropathic pain

Pain

Volumn 80, Issue 1-2, 1999, Pages 31-36

  Lavand'homme, Patricia M ^a   Eisenach, James C ^b  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b WAKE FOREST BAPTIST HEALTH   (United States)

Author keywords

Adenosine analogs; Morphine; Spinal administration

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR; DIPYRIDAMOLE; MORPHINE;

ALLODYNIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HYPERALGESIA; INTRASPINAL DRUG ADMINISTRATION; MALE; NERVE INJURY; NEURALGIA; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL NERVE;

ADENOSINE; ANALGESICS, OPIOID; ANIMALS; DEOXYADENOSINES; DIPYRIDAMOLE; DRUG SYNERGISM; INJECTIONS, SPINAL; LIGATION; MALE; MORPHINE; NEURITIS; PAIN; PAIN MEASUREMENT; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; SPINAL NERVES;

EID: 0032995813     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(98)00193-6     Document Type: Article

References (28)

1. Arner, S. and Meyerson, B.A., Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain, Pain, 33 (1988) 11-23.
2. Belfrage, M., Sollevi, A., Segerdahl, M., Sjolund, K.-F. and Hansson, P., Systemic adenosine infusion alleviates spontaneous and stimulus evoked pain in patients with peripheral neuropathic pain, Anesth. Analg., 81 (1995) 713-717.
3. Bian, D., Nichols, M.L., Ossipov, M.H., Lai, J. and Porreca, F., Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats, NeuroReport, 6 (1995) 1981-1984.
4. Cahill, C.M., White, T.D. and Sawynok, J., Spinal opioid receptors and adenosine release: Neurochemical and behavioral characterization of opioid subtypes, J. Pharmacol. Exp. Ther., 275 (1995) 84-93.
5. Cahill, C.M., White, T.D. and Sawynok, J., Substance P releases and augments the morphine-evoked release of adenosine from spinal cord, Brain Res., 760 (1997) 294-297.
6. Chaplan, S.R., Bach, F.W., Pogrel, J.W., Chung, J.M. and Yaksh, T.L., Quantitative assessment of tactile allodynia in the rat paw, J. Neurosci. Methods, 53 (1994) 55-63.
7. Cui, J.-G., Sollevi, A., Linderoth, B. and Meyerson, B.A., Adenosine receptor activation suppresses tactile hypersenitivity and potentiates spinal cord stimulation in mononeuropathic rats, Neurosci. Lett., 223 (1997) 173-176.
8. DeLander, G.E., Mosberg, H.I. and Porreca, F., Involvement of adenosine in antinociception produced by spinal or supraspinal receptor-selective opioid agonists: dissociation from gastrointestinal effects in mice, J. Pharmacol. Exp. Ther., 263 (1992) 1097-1104.
9. Karlsten, R. and Gordh, T. Jr., An Al-selective adenosine agonist abolishes allodynia elicited by vibration and touch after intrathecal injection, Anesth. Analg., 80 (1995) 844-847.
10. Keil, G.J. II and DeLander, G.E., Spinally-mediated antinociception is induced in mice by an adenosine kinase-, but not by an adenosine deaminase-, inhibitor, Life Sci., 51 (1992) PL171-PL176.
11. Keil, G.J. II and DeLander, G.E., Adenosine kinase and adenosine deaminase inhibition modulate spinal adenosine- and opioid agonist-induced antinociception in mice, Eur. J. Pharmacol., 271 (1994) 37-46.
12. Keil, G.J., II and DeLander, G.E., Time-dependent antinociceptive interactions between opioids and nucleoside transport inhibitors, J. Pharmacol. Exp. Ther., 274 (1995) 1387-1392.
13. Kim, S.H. and Chung, J.M., Sympathectomy alleviates mechanical allodynia in an experimental animal model for neuropathy in the rat, Neurosci. Lett, 134 (1991) 131-134.
14. Lee, Y.W., Chaplan, S.R. and Yaksh, T.L., Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model, Neurosci. Lett, 199 (1995) 111-114.
15. Lee, Y.W. and Yaksh, T.L., Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists., J. Pharmacol. Exp. Ther., 277 (1996) 1642-1648.
16. Merskey, H. and Hamilton, J.T., An open label trial of the possible analgesic effects of dipyridamole, J. Pain Symptom Manage., 4 (1989) 34-37.
17. Poon, A. and Sawynok, J., Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyper-algesia model in the rat, Pain, 74 (1998) 235-245.
18. Rane, K., Segerdahl, M. and Sollevi, A., Intrathecal adenosine to healthy volunteers - a tolerability study (Abstr.), Anesthesiology, 87 (1997) A741.
19. Santicioli, P., Del Bianco, E., Tramontana, M. and Maggi, C.A., Adenosine inhibits action potential-dependent release of calcitonin gene-related peptide and substance P-like immunoreactivities from primary afferents in rat spinal cord, Neurosci. Lett., 144 (1992) 211-214.
20. Sawynok, J., Adenosine receptor activation and nociception, Eur. J. Pharmacol., 347 (1998) 1-11.
21. Sawynok, J., Sweeney, M.I. and White, T.D., Adenosine release may mediate spinal analgesia by morphine, Trends Pharmacol. Sci., 10 (1989) 186-189.
22. Sjolund, K.-F., Sollevi, A., Segerdahl, M. and Lundeberg, T., Intrathecal adenosine analog administration reduces substance P in cerebrospinal fluid along with behavioral effects that suggest antinociception in rats, Anesth. Analg., 85 (1997) 627-632.
23. 2 adenosine receptors mediating the purine antinociception, motor and autonomic function in the rat spinal cord, J. Pharmacol. Exp. Ther., 250 (1989) 915-922.
24. Sumida, T., Smith, M.A., Maehara, Y., Collins, J.G. and Kitahata, L.M., Spinal R-phenyl-isopropyl adenosine inhibits spinal dorsal horn neurons responding to noxious heat stimulation in the absence and presence of sensitization, Pain, 74 (1998) 307-313.
25. Sweeney, M.I., White, T.D., Jhamandas, K.H. and Sawynok, J., Morphine releases endogenous adenosine from the spinal cord in vivo, Eur. J. Pharmacol., 141 (1987) 169-170.
26. + release purines from capsaicin- sensitive primary afferent nerve terminals in the spinal cord, J. Pharmacol. Exp. Ther., 248 (1989) 447-454.
27. Yaksh, T.L. and Rudy, T.A., Chronic catheterization of the spinal subarachnoid space, Physiol. Behav., 7 (1976) 1032-1036.
28. Yamamoto, T. and Yaksh, T.L., Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve: I, Opioid and nonopioid receptors, Anesthesiology, 75 (1991) 817-826.