Mass spectrometry and proteomics

Current Opinion in Chemical Biology

Volumn 4, Issue 5, 2000, Pages 489-494

  Gygi, Steven P ^a   Aebersold, Ruedi ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEOME;

AUTOMATION; MASS SPECTROMETRY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0033772588     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(00)00121-6     Document Type: Review

References (31)

1. Using mass spectrometry for quantitative proteomics
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3. Mass spectrometry. From genomics to proteomics
4. Mass spectrometric approaches for the identification of gel-separated proteins
5. Rapidly switchable MALDI and electrospray quadrupole-time-of-flight mass spectrometry for protein identification
6. MALDI quadrupole time-of-flight mass spectrometry: A powerful tool for proteomic research
7. The characteristics of peptide collision-induced dissociation using a high-performance MALDI-TOF/TOF tandem mass spectrometer
8. High throughput proteome-wide precision measurements of protein expression using mass spectrometry
9. Protein identification with a single accurate mass of a cysteine-containing peptide and constrained database searching
10. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
11. Probability-based protein identification by searching sequence databases using mass spectrometry data
12. Error-tolerant identification of peptides in sequence databases by peptide sequence tags
13. A strategy for rapid, high-confidence protein identification
14. Role of accurate mass measurement (+/-10 ppm) in protein identification strategies employing MS or MS/MS and database searching
15. Fluorescence detection of proteins in sodium dodecyl sulfate-polyacrylamide gels using environmentally benign, nonfixative, saline solution
16. Better approaches to finding the needle in a haystack: Optimizing proteome analysis through automation
17. A molecular scanner to automate proteomic research and to display proteome images
18. High sensitivity mass spectrometric methods for obtaining intact molecular weights from gel-separated proteins
19. Accurate quantitation of protein expression and site-specific phosphorylation
20. Isoelectric focusing nonporous RP HPLC: A two-dimensional liquid-phase separation method for mapping of cellular proteins with identification using MALDI-TOF mass spectrometry
21. Direct analysis of large protein complexes using mass spectrometry
22. Evaluation of two-dimensional gel electrophoresis based proteome analysis technology
23. Separation and identification of peptides from gel-isolated membrane proteins using a microfabricated device for combined capillary electrophoresis/nanoelectrospray mass spectrometry
24. Microfabricated polymer devices for automated sample delivery of peptides for analysis by electrospray ionization tandem mass spectrometry
25. Profiling of amyloid beta peptide variants using SELDI protein chip arrays
26. Application of isotope dilution-mass spectrometry in clinical chemistry, pharmacokinetics, and toxicology
27. Quantitative analysis of protein mixtures using isotope coded affinity tags
28. The yeast nuclear pore complex: Composition, architecture, and transport mechanism
29. A generic strategy to analyze the spatial organization of multi-protein complexes by cross-linking and mass spectrometry
30. A comprehensive characterization of the T-cell antigen receptor complex composition by micro-capillary liquid chromatography tandem mass spectrometry
31. A Sm-like protein complex that participates in mRNA degradation