Simulated molecular evolution in a full combinatorial library

Chemistry and Biology

Volumn 7, Issue 6, 2000, Pages 433-441

  Illgen, Katrin ^a   Enderle, Thilo ^a   Broger, Clemens ^a   Weber, Lutz ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Combinatorial chemistry; Combinatorial optimization; Evolutionary chemistry; Genetic algorithm; Thrombin inhibitors

Indexed keywords

COMBINATORIAL LIBRARY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR; ENZYME SYNTHESIS; GENETIC ALGORITHM; SERINE PROTEINASE; SIMULATION; STRUCTURE ACTIVITY RELATION; THROMBIN;

DARWINIA;

EID: 0034131234     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00122-8     Document Type: Article

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