Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factors

Journal of Virology

Volumn 74, Issue 17, 2000, Pages 8194-8201

  Lubyova, B ^a   Pitha, P M ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON;

ARTICLE; EXTRACTION; GENETIC CODE; HERPES VIRUS; HUMAN; HUMAN CELL; MOLECULAR CLONING; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION; VIRUS CHARACTERIZATION; VIRUS GENOME; VIRUS INFECTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; CLONING, MOLECULAR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 8, HUMAN; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTOR-7; INTERFERON REGULATORY FACTORS; INTERFERON-ALPHA; MICE; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; VIRAL PROTEINS;

EID: 0033900822     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.17.8194-8201.2000     Document Type: Article

References (47)

1. The primary sequence of rhesus monkey rhadinovirus isolate 26-95: Sequence similarities to Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus isolate 17577
2. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes
3. Characterization of the interferon regulatory factor-7, and its potential role in the transcription activation of interferon A genes
4. Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family
5. Unique properties of a second human Herpesvirus 8-encoded interferon regulatory factor (vIRF-2)
6. Functional analysis of the HHV-8 encoded vIRF-1 and its association with cellular IRFs and p300
7. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator
8. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation
9. KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway
10. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
11. Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3
12. Requirement for transcription factor IRF-1 in NO synthetase induction in macrophages
13. Point mutation defines a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes
14. Deficient cytokine signaling in mouse embryo fibroblasts with targeted deletion in the PKR gene: Role of IRF-1 and NF-κB
15. The role of cytokines in viral infections
16. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor
17. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
18. Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription
19. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
20. Virus-encoded receptors for cytokines and chemokines
21. Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells
22. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
23. Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma
24. Overview of the management of AIDS-related Kaposi's sarcoma
25. Molecular piracy of chemokine receptors by herpesviruses
26. Primary effusion lymphoma: A distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpesvirus
27. Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription
28. The growing family of interferon regulatory factors
29. Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/Re1A fusion proteins
30. A single 13-kilobase divergent locus in the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins
31. A two-step mechanism for recruitment of Pip by PU.1
32. Critical role of Kaposi's sarcoma virus (HHV-8)-encoded IRFs in virus replication and pathogenicity
33. Viral strategies of immune evasion
34. Upstream regulatory elements of murine a4 gene confer inducibility and cell type-restricted expression
35. Mouse genotype affects inducible expression of cytokine genes
36. Nucleotide sequence of the Kaposi's sarcoma-associated herpesvirus (HHV-8)
37. Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1)
38. Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
39. Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene
40. Regulation of type I interferon gene expression by interferon regulatory factor-3
41. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
42. Sequence and genomic analysis of a Rhesus macaque rhadinovirus with similarity to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8
43. Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA
44. Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage
45. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo
46. Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF-3 and CBP/p300
47. Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription