Relative transcriptional inducibility of the human interferon-α subtypes conferred by the virus-responsive enhancer sequence

Journal of Interferon and Cytokine Research

Volumn 16, Issue 2, 1996, Pages 99-107

  Dent, Carolyn L ^a   Macbride, Sonya J ^a   Sharp, Nigel A ^a   Gewert, Dirk R ^a  

^a WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ALPHA INTERFERON; ANTIBIOTIC G 418; DOUBLE STRANDED RNA; MESSENGER RNA; PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CONSTRUCT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENDAI VIRUS; TRANSCRIPTION REGULATION;

EID: 0030048597     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1996.16.99     Document Type: Article

References (50)

1. PAYNE, M.M., and LEADBEATER, L. (1991). The composition of lymphoblastoid interferon (Wellferon). J. Interferon Res. 11, S263.
2. DIAZ, M.O., POMYKALA, H.M., BOHLANDER, S.K., MALTEPE, E., MALIK, K., BROWNSTEIN, B., and OLOPADE, O.I. (1994). Structure of the human type-1 interferon gene cluster determined from a YAC clone contig. Genomics 22, 540-552.
3. HENCO, K., BROSIUS, J., FUJISAWA, A., FUJISAWA, J.-I., HAYNES, J.R., HOCHSTADT, J., KOVACIC, T., PASEK, M., SCHAMBOCK, A., SCHMID, J., TODOKORO, K., WALCHLI, M., NAGATA, S., and WEISSMANN, C. (1985). Structural relationship of human interferon alpha genes and pseudogenes. J. Mol. Biol. 185, 227-260.
4. DIAZ, M.O. (1995). The human type I interferon gene cluster. Semin. Virol. 6, 143-149.
5. MACDONALD, N.J., KUHL, D., MAGUIRE, D., NAF, D., GALLANT, P., GOSWAMY, A., HUG, H., BUELER, H., CHATURVEDI, M., DE LA FUENTE, J., RUFFNER, H., MEYER, F., and WEISSMANN, C. (1990). Different pathways mediate virus inducibility of the human IFN-a1 and IFN-b genes. Cell 60, 767-779.
6. RYALS, J., DIERKS, P., RAGG, H., and WEISSMANN, C. (1985). A 46-nucleotide promoter segment from an IFN-a gene renders an unrelated promoter inducible by virus. Cell 41, 497-507.
7. RAJ, N.B.K., ISRAELI, R., KELLUM, M., and PITHA, P.M. (1989). Upstream regulatory elements of murine α4-interferon gene confer inducibility and cell type-restricted expression. J. Biol. Chem. 264, 11149-11157.
8. HISCOTT, J., NGUYEN, H., and LIN, R. (1995). Molecular mechanisms of interferon beta gene induction. Semin. Virol. 6, 161-173.
9. FAN, C.-M., and MANIATIS, T. (1989). Two different virus-inducible elements are required for human b-interferon gene regulation. EMBO J. 8, 101-110.
10. GOODBOURN, S., ZINN, K., and MANIATIS, T. (1985). Human b-interferon gene expression is regulated by an inducible enhancer element. Cell 41, 509-520.
11. ZINN, K., DIMAIO, D., and MANIATIS, T. (1983). Identification of two distinct regulatory regions adjacent to the human b-interferon gene. Cell 34, 865-879.
12. FUJITA, T., SAKAKIBARA, J., SUDO, Y., MIYAMOTO, M., KIMURA, Y., and TANIGUCHI, T. (1988). Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-b gene regulatory elements. EMBO J. 7, 3397-3405.
13. HARADA, H., FUJITA, T., MIYAMOTO, M., KIMURA, Y., MARUYAMA, M., FURIA, A., MIYATA, T., and TANIGUCHI, T. (1989). Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58, 729-739.
14. ITOH, S., HARADA, H., FUJITA, T., MIMURA, T., and TANIGUCHI, T. (1989). Sequence of a cDNA coding for human IRF-2. Nucleic Acids Res. 20, 8372.
15. LENARDO, M.J., FAN, C.-M., MANIATIS, T., and BALTIMORE, D. (1989). The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as a widely inducible mediator of signal transduction. Cell 57, 387-294.
16. MIYAMOTO, M., FUJITA, T., KIMURA, Y., MARUYAMA, M., HARADA, H., SUDO, Y., MIYATA, T., and TANIGUCHI, T. (1988). Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell 54, 903-913.
17. NOURBAKHSH, M., HOFFMANN, K., and HAUSER, H. (1993). Interferon-b promoters contain a DNA element that acts as a position-independent silencer on the NF-kB site. EMBO J. 12, 451-459.
18. PINE, R., DECKER, T., KESSLER, D.S., LEVY, D.E., and DARNELL, J.E. (1990). Purification and cloning of interferon-stimuIated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either. Mol. Cell. Biol. 10, 2448-2457.
19. REIS, L.F.L., HARADA, H., WOLCHOK, J.D., TANIGUCHI, T., and VILCEK, J. (1992). Critical role of a common transcription factor, IRF-1, in the regulation of IFN-b and IFN-inducible genes. EMBO J. 11, 185-193.
20. THANOS, D., and MANIATIS, T. (1992). The high mobility group protein HMG-I(Y) is required for NF-kB-dependent virus induction of the human IFN-b gene. Cell 71, 777-789.
21. VISVANATHAN, K.V., and GOODBOURN, S. (1989). Double stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter. EMBO J. 8, 1129-1138.
22. WHITESIDE, S.T., VISVANATHAN, K.V., and GOODBOURN, S. (1992). Identification of novel factors that bind to the PRD I region of the human b-interferon promoter. Nucleic Acids Res. 20, 1531-1538.
23. PITHA, P.M., and AU, W.-C. (1995). Induction of interferon alpha genes expression. Semin. Virol. 6, 151-159.
24. BISAT, F., RAJ, N.B.K., and PITHA, P.M. (1988). Differential and cell type specific expression of murine alpha-interferon genes is regulated on the transcriptional level. Nucleic Acids Res. 16, 6067-6083.
25. KELLY, K.A., and PITHA, P.M. (1985). Characterization of a mouse interferon gene locus II. Differential expression of α-interferon genes. Nucleic Acids Res. 13, 825-839.
26. RAJ, N.B.K., AU, W.-C., and PITHA, P.M. (1991). Identification of a novel virus-responsive sequence in the promoter of murine interferon-α genes. J. Biol. Chem. 266, 11360-11365.
27. DRON, M., LACASA, M., and TOVEY, M.G. (1990). Priming affects the activity of a specific region of the promoter of the human beta interferon gene. Mol. Cell. Biol. 10, 854-858.
28. 1 gene. J. Biol. Chem. 260, 14242-14247.
29. DIAZ, M.O., BOHLANDER, S., and ALLEN, G. (1994). Nomenclature of the human interferon genes. J. Interferon Res. 14, 221-222.
30. ALLEN, G., and DIAZ, M.O. (1994). Nomenclature of the human interferon proteins. J. Interferon Res. 14, 223-226.
31. LINSHAL, T., KLEIN, G., REEDMAN, B.M., JOHANSSON, B., and SINGH, S. (1974). Relationship between Epstein-Barr virus (EBV) DNA and the EBV-determined nuclear antigen (EBNA) in Burkitt's lymphoma biopsies and other lymphoproliferative malignancies. Int. J. Cancer 13, 764-772.
32. COUTLEE, F., RUBALCABA, E.A., VISCIDI, R.P., GERN, J.E., MURPHY, P.A., and LEDERMAN, H.M. (1990). Quantitative detection of messenger RNA by solution hybridization and enzyme immunoassay. J. Biol. Chem. 265, 11601-11604.
33. ALTING-MEES, M.A., and SHORT, J.M. (1989). pBluescript II: gene mapping vectors. Nucleic Acids Res. 17, 9494.
34. BERGER, J., HAUBER, J., HAUBER, R., and CULLEN, B.R. (1988). Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells. Gene 66, 1-10.
35. MILLÁN, J.L. (1986). Molecular cloning and sequence analysis of human placental alkaline phosphatase. J. Biol. Chem. 261, 3112-3115.
36. LUCKLOW, B., and SCHÜTZ, G. (1987). CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15, 5490.
37. PAGE, M.J., and SYDENHAM, M.A. (1991). High level expression of the humanized monoclonal antibody campath-1H in chinese hamster ovary cells. BioTechnology 9, 64-68.
38. MORGENSTERN, J.P., and LAND, H. (1990). A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells. Nucleic Acids Res. 18, 1068.
39. GAUSS, G.H., and LIEBER, M.R. (1992). DEAE-dextran enhances electroporation of mammalian cells. Nucleic Acids Res. 20, 6739-6740.
40. HISCOTT, J., CANTELL, K., and WEISSMANN, C. (1984). Differential expression of human interferon genes. Nucleic Acids Res. 12, 3727-3746.
41. BRANDT, E.R., LINNANE, A.W., and DEVENISH, R.J. (1994). Expression of IFN A genes in subpopulations of peripheral blood cells. Br. J. Haematol. 86, 712-725.
42. WHITTEMORE, L.-A., and MANIATIS, T. (1990). Postinduction turnoff of beta-interferon gene expression. Mol. Cell. Biol. 64, 1329-1337.
43. GRAFI, G., SELA, I., and GALILI, G. (1993). Translational regulation of human beta interferon mRNA: Association of the 3′ AU-rich sequence with the poly(A) tail reduces translation efficiency in vitro. Mol. Cell. Biol. 13, 3487-3493.
44. RAJ, N.B.K., and PITHA, P.M. (1993). 65-kDa protein binds to destabilizing sequences in the IFN-β mRNA coding and 3′ UTR. FASEB J. 7, 702-710.
45. FUJITA, T., KIMURA, Y., MIYAMOTO, M., BARSOUMIAN, E.L., and TANIGUCHI, T. (1989). Induction of endogenous IFN-a and IFN-b genes by a regulatory transcription factor, IRF-1. Nature 337, 270-272.
46. RUFFNER, H., REIS, L.F.L., NAF, D., and WEISMANN, C. (1993). Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1. Proc. Natl. Acad. Sci. USA 90, 11503-11507.
47. REIS, L.F.L., RUFFNER, H., STARK, G., AGUET, M., and WEISSMANN, C. (1994). Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes. EMBO J. 13, 4798-4806.
48. LEHMING, N., THANOS, D., BRICKMAN, J.M., MA, J., MANIATIS, T., and PTASHNE, M. (1994). An HMG-like protein that can switch a transcriptional activator to a repressor. Nature 371, 175-179.
49. LIN, H.-Y., DAVIS, P.J., and THACORE, H.R. (1991). Production of human interferon-β by Sendai virus and poly(rI)·poly(rC): inhibition by neomycin. J. Interferon Res. 11, 365-369.
50. LANGELAND, N., HOLMSEN, H., LILLEHAUG, J.R., and HAARR, L. (1987). Evidence that neomycin inhibits binding of herpes simplex virus type 1 to the cellular receptor. J. Virol. 61, 3388-3393.