Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain

Molecular and Cellular Biology

Volumn 20, Issue 23, 2000, Pages 8803-8814

  Marie I ^a   Smith, E ^a   Prakash, A ^a   Levy, D E ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; DNA; ESTROGEN RECEPTOR; GENE PRODUCT; INTERFERON INDUCING AGENT; INTERFERON REGULATORY FACTOR 7;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; DNA SEQUENCE; EMBRYO; HUMAN; HUMAN CELL; KINETICS; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANIMALS; CELL COMPARTMENTATION; CELL NUCLEUS; CELLS, CULTURED; DIMERIZATION; DNA-BINDING PROTEINS; INTERFERON REGULATORY FACTOR-7; INTERFERON-ALPHA; INTERFERONS; MICE; NEWCASTLE DISEASE VIRUS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0034461577     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.23.8803-8814.2000     Document Type: Article

References (54)

1. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes
2. Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
3. Combinatorial association and abundance of interferon-stimulated gene factor 3 components dictate the selectivity of interferon responses
4. Cooperativity and dimerization of recombinant human estrogen receptor hormone-binding domain
5. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1
6. Assembly requirements of PU.1-Pip (IRF-4) activator complexes: Inhibiting function in vivo using fused dimers
7. Pip, a novel IRF family member, is a lymphoid-specific, Pu.1-dependent transcriptional activator
8. Interferon-beta is required for interferon-alpha production in mouse fibroblasts
9. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation
10. Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences
11. Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1
12. Solution structure of the IRF-2 DNA-binding domain: A novel subgroup of the winged helix-turn-helix family
13. Transcription activation by estrogen and progesterone receptors
14. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
15. Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3
16. A conditionally active form of STAT6 can mimic certain effects of IL-4
17. Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes
18. IFN-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator
19. In vivo formation of IRF-1 homodimers
20. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1
21. Analysis of interferon-regulated proteins binding the interferon-alpha-stimulated response element
22. Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription
23. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
24. Structural and functional analysis of interferon regulatory factor 3: Localization of the transactivation and autoinhibitory domains
25. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
26. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
27. Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors
28. Design of conditionally active STATs: Insights into STAT activation and gene regulatory function
29. Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex
30. The growing family of interferon regulatory factors
31. Virus infection leads to localized hyperacetylation of histories H3 and H4 at the IFN-beta promoter
32. Signal transduction by steroid hormones: Nuclear localization is differentially regulated in estrogen and glucocorticoid receptors
33. A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor
34. Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection
35. Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity
36. A vector for expressing GAL4(1-147) fusions in mammalian cells
37. Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
38. Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene
39. Regulation of type I interferon gene expression by interferon regulatory factor-3
40. Functional domains of interferon regulatory factor I (IRF-1)
41. A novel IFN-α-regulated DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene
42. Functional domain analysis of interferon consensus sequence binding protein (1CSBP) and its association with interferon regulatory factors
43. Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA
44. Interferon-induced nuclear signaling by Jak protein tyrosine kinases
45. Rasindependent signal transduction in response to growth factors and cytokines by tyrosine phosphorylation of a common transcription factor
46. Interferon regulatory factors: Growth control and histone gene regulation - It's not just interferon anymore
47. Two domains of ISGF3gamma that mediate protein-DNA and protein-protein interaction during transcription factor assembly contribute to DNA-binding specificity
48. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and myb families of DNA-binding proteins
49. Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis
50. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo
51. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1
52. Reconstitution of virus-mediated expression of interferon alpha genes in human fibroblast cells by ectopic interferon regulatory factor-7
53. Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors
54. Direct triggering of the type I interferon system by virus infection: Activation of a transcription factor complex containing IRF-3 and CBP/p300